当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Differences in the ability of salbutamol to prevent and reverse LTC4-induced contractions of the guinea-pig isolated trachea: influence of l-serine borate.

Differences in the ability of salbutamol to prevent and reverse LTC4-induced contractions of the guinea-pig isolated trachea: influence of l-serine borate.

Abstract：

:In the presence of l-serine borate, salbutamol was much more effective in reversing rather than preventing LTC4-induced contractions of guinea-pig trachea. This suggests that different mechanisms are involved in initiating versus maintaining LTC4-induced contractions. In addition, the ability of salbutamol pretreatment to prevent LTC4-induced contractions was reduced substantially in the presence of l-serine borate, suggesting that the metabolites of LTC4 (LTD4 and LTE4) are more sensitive to inhibition by beta-adrenoceptor agonists than is LTC4 itself.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Hay DW,Muccitelli RM,Wilson KA,Wasserman MA,Torphy TJ

doi

10.1016/0014-2999(86)90066-x

subject

Has Abstract

pub_date

1986-07-31 00:00:00

pages

323-7

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(86)90066-X

journal_volume

126

pub_type

杂志文章

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