Abstract:
:Dopamine agents (saline in control groups) were coadministered with indomethacin by either single or repeated application. The ulcerogenic effect (erosions and/or ulcers) of repeated given indomethacin on gastric mucosa differed clearly from that on intestinal mucosa. The effect on intestinal mucosa was markedly greater than after a single dose. The effects of dopamine agents appeared to be more consistent. Domperidone and haloperidol, given as single or repeated doses, strongly aggravated both the gastric and intestinal lesions. Bromocriptine and amantadine had a protective effect. The adverse effects of both dopamine antagonists (increased after repeated administration) were strongly inhibited by the simultaneous administration of either bromocriptine or amantadine. The involvement of the dopamine system (central or peripheral) in the mechanisms that maintain gastric (probably related to cytoprotection also) and intestinal mucosa integrity is therefore suggested.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Sikirić P,Rotkvić I,Mise S,Krizanac S,Gjuris V,Jukić J,Suchanek E,Petek M,Udovicić I,Kalogjera Ldoi
10.1016/0014-2999(88)90253-1subject
Has Abstract,Author List Incompletepub_date
1988-12-06 00:00:00pages
61-7issue
1-2eissn
0014-2999issn
1879-0712pii
0014-2999(88)90253-1journal_volume
158pub_type
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