In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF.

Abstract:

:Thiorphan, the potent inhibitor of 'enkephalinase', has shown some analgesic properties in experimental animals and in man. The possibility that the intravenous infusion of acetorphan, a prodrug of thiorphan (26 micrograms/kg per min for 60 min), can inhibit plasma and cerebrospinal fluid (CSF) enkephalinase in man in vivo was investigated. A decrease of approximately 65% in enzyme activity was observed in both plasma and CSF. Acetorphan did not induce any significant variation of plasma angiotensin-converting enzyme activity.

journal_name

Eur J Pharmacol

authors

Spillantini MG,Geppetti P,Fanciullacci M,Michelacci S,Lecomte JM,Sicuteri F

doi

10.1016/0014-2999(86)90094-4

subject

Has Abstract

pub_date

1986-06-05 00:00:00

pages

147-50

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(86)90094-4

journal_volume

125

pub_type

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