Abstract：
:18-Methoxycoronaridine, a novel iboga alkaloid congener, reduces drug self-administration in animal models of addiction. Previously, we proposed that these effects are mediated by the ability of 18-methoxycoronaridine to inhibit nicotinic alpha3beta4 acetylcholine receptors. In an attempt to identify more potent 18-methoxycoronaridine analogs, we have tested a series of 18-methoxycoronaridine congeners by whole-cell patch clamp recording of HEK 293 cells expressing recombinant nicotinic alpha3beta4 receptors or glutamate NR1/NR2B N-methyl-d-aspartate (NMDA) receptors. The congeners exhibited a range of inhibitory potencies at alpha3beta4 receptors. Five congeners had IC(50) values similar to 18-methoxycoronaridine, and all of these were ineffective at NMDA receptors. The congeners also retained their ability to reduce morphine and methamphetamine self-administration. These data are consistent with the importance of nicotinic alpha3beta4 receptors as a therapeutic target to modulate drug seeking. These compounds may constitute a new class of synthetic agents that act via the nicotinic alpha3beta4 mechanism to combat addiction.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Pace CJ,Glick SD,Maisonneuve IM,He LW,Jokiel PA,Kuehne ME,Fleck MWdoi
10.1016/j.ejphar.2004.03.062keywords:
subject
Has Abstractpub_date
2004-05-25 00:00:00pages
159-67issue
2-3eissn
0014-2999issn
1879-0712pii
S0014299904003723journal_volume
492pub_type
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