Characterization of contractile prostanoid receptors on human airway smooth muscle.

abstract：:The LTD4 antagonist, Wy-48,252 (1,1,1-trifluoro-N-[3-(2-quinolinylmethoxy)phenyl]methanesulfonamide), was assessed for its ability to modulate arachidonic acid metabolism in several inflammatory cells. In A23187-stimulated rat neutrophils, Wy-48,252 effectively inhibited the conversion of exogenous [14C]arachidonic ac...

journal_title：European journal of pharmacology

authors： Chang J,Borgeat P,Schleimer RP,Musser JH,Marshall LA,Hand JM

更新日期：1988-03-22 00:00:00

abstract：:An unbiased conditioned place preference paradigm was used to evaluate the effect of dextro-morphine on the morphine-produced reward in male CD rats. Morphine sulfate (1-10 mg/kg) given intraperitoneally dose-dependently produced the conditioned place preference. Pretreatment with dextro-morphine at a dose from 0.1 to...

journal_title：European journal of pharmacology

authors： Wu HE,Schwasinger ET,Terashvili M,Tseng LF

更新日期：2007-05-21 00:00:00

abstract：:Autophagy is a lysosomal degradation pathway, which is essential for cell survival, proliferation, differentiation and homeostasis. It is well known that beta-amyloid (Aβ) aggregation is one of key characteristics for Alzheimer's disease (AD), which triggers a complex pathological cascade, leading to neurodegeneration...

journal_title：European journal of pharmacology

authors： Wang C,Zhang X,Teng Z,Zhang T,Li Y

更新日期：2014-10-05 00:00:00

abstract：:Two splice variants of the pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor (PACAP receptor and PACAP/HOP receptor isoform) were stably expressed in Chinese hamster ovary (CHO) cells that did not express constitutively receptors for this family of peptides. The PACAP/HOP receptor protein had ...

journal_title：European journal of pharmacology

authors： Ciccarelli E,Svoboda M,De Neef P,Di Paolo E,Bollen A,Dubeaux C,Vilardaga JP,Waelbroeck M,Robberecht P

更新日期：1995-02-15 00:00:00

abstract：:The action of a novel 5-HT3 receptor antagonist, AS-5370, has been studied on two electrophysiological models for 5-HT3 receptors: whole-cell patch-clamp recordings from mouse neuroblastoma-rat glioma (NG108-15) cells and grease-gap recordings from rat isolated vagus nerve. The 5-hydroxytryptamine (5-HT)-induced fast ...

journal_title：European journal of pharmacology

authors： Newberry NR,Sprosen TS,Watkins CJ,Leslie RA,Grahame-Smith DG

更新日期：1992-08-14 00:00:00

abstract：:The ability of calcium entry blockers to inhibit allergic histamine release from rabbit leukocytes was studied. Bepridil, verapamil, nifedipine, diltiazem and TMB-8 produced concentration-dependent inhibition of allergic histamine release from rabbit leukocytes. The calculated IC50s (microM) were as follows: verapamil...

journal_title：European journal of pharmacology

authors： Chand N,Pillar J,Diamantis W,Sofia RD

更新日期：1985-01-08 00:00:00

abstract：:Levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide, ucb L059) is a novel potential antiepileptic agent presently in clinical development with unknown mechanism of action. The finding that its anticonvulsant activity is highly stereoselective (Gower et al., 1992) led us to investigate the presence of specific b...

journal_title：European journal of pharmacology

authors： Noyer M,Gillard M,Matagne A,Hénichart JP,Wülfert E

更新日期：1995-11-14 00:00:00

abstract：:MK-801, phenobarbital and clonazepam blocked convulsions elicited in mice by bicuculline. Treatment with Ro 15-1788 antagonized the anticonvulsant action of clonazepam, but not MK-801 or phenobarbital. The anticonflict effect in the rat of chlordiazepoxide, but not MK-801, was antagonized by Ro 15-1788. Despite having...

journal_title：European journal of pharmacology

authors： Clineschmidt BV

更新日期：1982-10-15 00:00:00

abstract：:Ginsenoside Rg3 (Rg3), one of the bioactive extracts found in ginseng root, was reported to have anti-cancer activity in various cancer models. The anti-proliferation effect of Rg3 on prostate cancer cells has been well reported. To test whether Rg3 has an anti-metastatic effect on prostate cancer, we treated a highly...

journal_title：European journal of pharmacology

authors： Pan XY,Guo H,Han J,Hao F,An Y,Xu Y,Xiaokaiti Y,Pan Y,Li XJ

更新日期：2012-05-15 00:00:00

abstract：:We have examined the effect of ropivacaine, a local anesthetic, on leukocyte-endothelium interactions induced by tumor necrosis factor-alpha (TNF-alpha) in vivo by the use of intravital microscopy in the mouse cremaster microcirculation. It was found that ropivacaine markedly reduced venular leukocyte adhesion and tis...

journal_title：European journal of pharmacology

authors： Zhang XW,Thorlacius H

更新日期：2000-03-24 00:00:00

abstract：:Opiate agonists exhibiting selectivity for mu, kappa, sigma, and delta opiate receptors were microinjected into the periaqueductal gray region (PAG) of the brain of rats to determine the receptor subtype(s) associated with the initiation of descending pain inhibition. The spinally organized, heat nociceptive tail-flic...

journal_title：European journal of pharmacology

authors： Smith DJ,Perrotti JM,Crisp T,Cabral ME,Long JT,Scalzitti JM

更新日期：1988-10-26 00:00:00

abstract：:Seroma formation is one of the most common complications following breast cancer surgery. It may lead to delay of adjuvant therapies and increasement of therapy costs. Bleomycin sulfate is a sclerosing antibiotic with antineoplastic efficacy. It is locally used in the treatment of pleural effusion. The present study a...

journal_title：European journal of pharmacology

authors： Eser M,Gökçeimam M,Eyvaz K,Tutal F,Geçer MÖ,Göktaş S,Uzun H,Kaptanoglu L,Kurt N

更新日期：2014-01-15 00:00:00

abstract：:The Role of protein kinase C in the modulatory effect of a mu-opioid receptor agonist, [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO), on the glycine-gated Cl(-) current was examined in acutely dissociated rat periaqueductal gray neurons. Using the nystatin-perforated patch-clamp technique, the neurons were voltag...

journal_title：European journal of pharmacology

authors： Jeong HJ,Lee JJ,Hahm ET,Han SH,Min BI,Cho YW

更新日期：2001-11-16 00:00:00

abstract：:In the guinea-pig isolated ileum, beta-(2-thienyl)-gamma-aminobutyric acid (BTG; 100-500 microM) reversibly and competitively (pA2 = 4.3 +/- 0.1) antagonised the baclofen-induced (5-100 microM) depression of cholinergic twitch contractions, but not that to adenosine or morphine. By contrast, in rat neocortical slice p...

journal_title：European journal of pharmacology

authors： Ong J,Kerr DI,Berthelot P,Vaccher C,Flouquet N,Debaert M

更新日期：1992-10-06 00:00:00

abstract：:The binding characteristics of compound 48/80 were examined using rat mast cells and fractionated 14C-labeled compound 48/80 components at 4 degrees C in vitro where no degranulation of the cells occurred. The binding potencies of these components in the presence of Ca2+ generally paralleled their histamine releasing ...

journal_title：European journal of pharmacology

authors： Koibuchi Y,Ichikawa A,Nakagawa M,Tomita K

更新日期：1985-09-24 00:00:00

abstract：:Nomifensine, at a dose of 40 mg/kg, slightly but significantly increased rat striatal acetylcholine 60 min after i.p. administration without affecting choline levels or choline O-acetyltransferase and cholinesterase activities. This drug had no effect on brainstem acetylcholine. In contrast, d-amphetamine and desipram...

journal_title：European journal of pharmacology

authors： Garattini S,Consolo S,Chittò G,Peri G,Ladinsky H

更新日期：1976-01-01 00:00:00

abstract：:The antinociceptive effect of intraplantar (i.pl.) ICI 204448 ((R,S)-N-[2-(N-methyl-3,4-dichloro-phenylacetamido)-2-(3-carbox yph enyl)- ethyl]pyrrolidine hydrochloride)) (20, 30, 40 and 50 micrograms), a kappa-opioid receptor agonist which has limited access to the central nervous system, was studied in a well-establ...

journal_title：European journal of pharmacology

authors： Keïta H,Kayser V,Guilbaud G

更新日期：1995-04-24 00:00:00

abstract：:Our aim in performing this study was to analyze in vivo the cell death mechanism induced by toxic doses of digitalis compounds on guinea-pig cardiomyocytes. We analyzed three study groups of five male guinea pigs each. Guinea pigs were intoxicated under anesthesia with ouabain or digoxin (at a 50-60% lethal dose); the...

journal_title：European journal of pharmacology

authors： Ramirez-Ortega M,Zarco G,Maldonado V,Carrillo JF,Ramos P,Ceballos G,Melendez-Zajgla J,Garcia N,Zazueta C,Chanona J,Suarez J,Pastelin G

更新日期：2007-07-02 00:00:00

abstract：:Microdialysis of the substantia nigra pars reticulata in freely moving rats disclosed a steady release of dopamine and its metabolites which was greatly reduced after reserpine (4 mg/kg s.c.) and alpha-methyl-p-tyrosine (200 mg/kg i.p.) pretreatments. Local infusion of high K+ (100 mM) or L-3,4-dihydroxyphenylalanine ...

journal_title：European journal of pharmacology

authors： Biggs CS,Fowler LJ,Whitton PS,Starr MS

更新日期：1996-03-28 00:00:00

abstract：:The effect of resveratrol, an aryl hydrocarbon receptor antagonist, on the teratogenicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated. Pregnant C57BL/6J mice were orally administered resveratrol (50 mg/kg) for 6 consecutive days, from gestational day (GD) 8 to GD13, followed by an oral chall...

journal_title：European journal of pharmacology

authors： Jang JY,Park D,Shin S,Jeon JH,Choi BI,Joo SS,Hwang SY,Nahm SS,Kim YB

更新日期：2008-09-04 00:00:00

abstract：:The function of multidrug resistance-associated protein 2 (Mrp2) in the intestine and liver, as well as intestinal Mrp2 expression, was analyzed in CCl(4)-induced acute hepatic failure rats with hyperbilirubinemia. The plasma level of bilirubin glucuronides, endogenous Mrp2-substrates, was 26 microM at 24 h after CCl(...

journal_title：European journal of pharmacology

authors： Yokooji T,Murakami T,Yumoto R,Nagai J,Takano M

更新日期：2006-09-28 00:00:00

abstract：:CGP 11305 A (4-(5-methoxy-7-bromo-benzofuranyl)2-piperidine-HCl) inhibited serotonin (5-HT) deamination in brains and livers of pretreated rats. The ED50S were 1 and 0.7 mg/kg p.o., respectively. Phenylethylamine (PEA) deamination was only marginally affected up to doses of 100 mg/kg p.o. The duration of action of the...

journal_title：European journal of pharmacology

authors： Waldmeier PC,Felner AE,Tipton KF

更新日期：1983-10-14 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is one of the risk factors for Parkinson's disease (PD). Insulin desensitisation has been observed in the brains of patients, which may promote neurodegeneration. Incretins are a family of growth factors that can re-sensitise insulin signalling. We have previously shown that mimetics of...

journal_title：European journal of pharmacology

authors： Yuan Z,Li D,Feng P,Xue G,Ji C,Li G,Hölscher C

更新日期：2017-10-05 00:00:00

abstract：:5-HT and dopamine receptor antagonists have become widely used as atypical antipsychotics. Although 5-HT(2A) receptor antagonistic activity is thought to contribute to the atypical aspects of these agents, the precise mechanism remains unknown. M100907 (R(+)-alpha(2,3-dimethoxyphenyl)-1-[2(4-fluorophenyl)ethyl)]-4-pip...

journal_title：European journal of pharmacology

authors： Habara T,Hamamura T,Miki M,Ohashi K,Kuroda S

更新日期：2001-04-13 00:00:00

abstract：:We aimed to develop an anovulation model, using sulpiride-induced hyperprolactinemia in common marmosets. The serum prolactin level gradually increased during the twice-daily administration of sulpiride and reached a plateau after 4 days. Sulpiride produced as big a response at 10 mg kg(-1) as at 50 mg kg(-1). In this...

journal_title：European journal of pharmacology

authors： Moro M,Inada Y,Kojima M,Miyata H,Komatsu H,Torii R

更新日期：1999-02-26 00:00:00

abstract：:We have studied the effects of withdrawal from chronic clonidine treatment in the adult male spontaneously hypertensive rat (SHR). SHR received clonidine, 0.1 mg X kg-1 X day-1 i.v. for 10 days. Clonidine was delivered via osmotic minipumps. After 7 days of treatment there was a 16.5 +/- 2.5 mm Hg fall in mean arteria...

journal_title：European journal of pharmacology

authors： Atkinson J,Lambas-Senas L,Parker M,Boillat N,Luthi P,Sonnay M,Seccia M,Renaud B

更新日期：1986-02-11 00:00:00

abstract：:The present study examined the effects of histamine on somatostatin-like immunoreactivity levels, binding of 125I-[Tyr11]somatostatin to its specific receptors, somatostatin inhibition of basal and forskolin-stimulated adenylyl cyclase activity and inhibitory guanine-nucleotide binding protein (Gi) function in the rat...

journal_title：European journal of pharmacology

authors： Puebla L,Arilla E

更新日期：1995-04-28 00:00:00

abstract：:Low doses of BHT 920, LY 171555 and (+)3PPP, three dopamine agonists selective for D-2 receptors, induced yawning in rats. This effect was reduced by the selective D-1 antagonist SCH 23390 but the antagonism did not exceed a 50% reduction from the control values. In contrast, the selective D-2 antagonist (-)sulpiride ...

journal_title：European journal of pharmacology

authors： Longoni R,Spina L,Di Chiara G

更新日期：1987-02-10 00:00:00

abstract：:The effects of intracisternal injections of [Lys8]vasopressin and [Arg8]vasopressin (25, 50, 100, 200 mU/kg) and related compounds oxytocin (25, 50, 100, 200 mU/kg), felypressin (25, 50, 100, 200 mU/kg) and vasotocin (100, 200, 400, 800 ng/kg) on the acute neurogenic pressor responses to afferent vagal stimulation (5,...

journal_title：European journal of pharmacology

authors： Montastruc P,Dang Tran L,Montastruc JL

更新日期：1985-11-19 00:00:00

abstract：:The Ah receptor (AhR) mediates many, if not all, of the toxic and biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related halogenated aromatic hydrocarbons. Although wide variations in species sensitivity to these compounds have been observed, numerous biochemical and physiochemical charac...

journal_title：European journal of pharmacology

authors： Bank PA,Yao EF,Phelps CL,Harper PA,Denison MS

更新日期：1992-09-01 00:00:00