Abstract:
:We are interested in the rat as an animal model for infant-mother attachment. In the first experiment we tried to distinguish between a preference for familiar animals (attachment theory) and a preference for genetically related animals (kin selection theory) with the use of an early cross-fostering procedure. Genetic relationships did not influence preferences in cross-fostered pups on postnatal day 17, only familiarity did. Subsequently we investigated if peptides known to influence affiliative behaviors were also effective in the present paradigm. Injection of oxytocin into the cisterna magna did not yield significant effects on preference, while vasopressin and desglycinamide-[Arg8]vasopressin reduced the preference in a dose dependent manner. The effect of vasopressin was completely blocked by pretreatment with the vasopressin V(1A) receptor antagonist d(CH2)5Tyr(Me)(2),Arg(8)-vasopressin. We discuss the explanatory power of attachment theory and kin selection theory with regard to preference experiments in rats and the usefulness of the rat as an animal model for infant-mother attachment.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Sigling HO,Wolterink-Donselaar IG,Spruijt BMdoi
10.1016/j.ejphar.2009.03.070subject
Has Abstractpub_date
2009-06-10 00:00:00pages
48-53issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(09)00318-5journal_volume
612pub_type
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