Abstract:
:The release of newly synthesised [3H]acetylcholine was evoked by electrical field stimulation (5 Hz, 600 pulses) of epithelium-deprived guinea-pig trachea strips after sensory neuropeptides depletion with 3 microM capsaicin. The selective tachykinin NK(2) receptor agonist [betaAla(8)]neurokinin A-(4-10) increased in a concentration-dependent manner the electrically-induced release of [3H]acetylcholine. The facilitatory effect was antagonised by the selective non-peptide tachykinin NK(2) receptor antagonist, SR 48968 (apparent pK(B) 8.9). The tachykinin NK(1) and NK(3) receptor agonists substance P methyl ester and senktide (both 10 and 100 nM), respectively, did not affect the evoked release of [3H]acetylcholine. It is concluded that the cholinergic nerves of guinea-pig trachea are endowed with prejunctional facilitatory tachykinin receptors of the NK(2) subtype.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
D'Agostino G,Erbelding D,Kilbinger Hdoi
10.1016/s0014-2999(00)00199-0keywords:
subject
Has Abstractpub_date
2000-05-12 00:00:00pages
29-32issue
1eissn
0014-2999issn
1879-0712pii
S0014-2999(00)00199-0journal_volume
396pub_type
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