The effects of HGCl2 and mersalyl on mechanisms regulating intracellular calcium and transmitter release.

Abstract:

:HgCl2 and mersalyl increased and later decreased both the spontaneous and evoked transmitter liberation at the frog neuromuscular junction. Lower concentration of HgCl2 exhibited only an inhibitory effect on transmitter release. These mercurials inhibited calcium transport of mitochondria and synaptosomal vesicles. Lower concentrations of HgCl2 showed a stimulatory effect on mitochondrial calcium uptake. It is suggested that the effect of mercurials on transmitter release is mediated via changes of the intracellular calcium ion concentration.

journal_name

Eur J Pharmacol

authors

Binah O,Meiri U,Rahamimoff H

doi

10.1016/0014-2999(78)90438-7

subject

Has Abstract

pub_date

1978-10-15 00:00:00

pages

453-7

issue

4

eissn

0014-2999

issn

1879-0712

pii

0014-2999(78)90438-7

journal_volume

51

pub_type

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