Effects of THA on ionic currents in myelinated axons of Xenopus laevis.

abstract：:The peroxisome proliferator-activated receptor-α (PPAR-α) controls the lipid and glucose metabolism and also affects inflammation, cell proliferation and apoptosis during cardiovascular disease. Raspberry ketone (RK) is a red raspberry (Rubusidaeus, Family-Rosaceae) plant constituent, which activates PPAR-α. This stud...

journal_title：European journal of pharmacology

authors： Khan V,Sharma S,Bhandari U,Sharma N,Rishi V,Haque SE

更新日期：2019-01-05 00:00:00

abstract：:The present study was undertaken to compare the properties of the [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) binding site in the dorsal raphe nucleus with the hippocampal 5-HT1A receptor. In both tissues inclusion of 1 mM Mg2+ enhanced specific [3H]8-OH-DPAT binding, while 1 mM GTP decreased radioligand bi...

journal_title：European journal of pharmacology

authors： Johnson RG,Fiorella D,Winter JC,Rabin RA

更新日期：1997-06-18 00:00:00

abstract：:In urethane-anesthetized rats, the effects of intravenous injections of morphine, levorphanol, dextrorphan, pentazocine and naloxone were studied studied on the activity in nerve fibres of the cervical sympathetic trunk, and on mean arterial blood pressure and heart rate. Impulse frequency in sympathetic nerve fibres ...

journal_title：European journal of pharmacology

authors： Jurna I,Rummel W

更新日期：1984-05-18 00:00:00

abstract：:Endo/sarcoplasmic reticulum stress and the unfolded protein response have been implicated as underlying mechanisms of cell death in many pathological conditions. We have confirmed that long-term exposure to 10µM tunicamycin induced the endo/sarcoplasmic reticulum stress in cultured vascular smooth muscle cells. Since ...

journal_title：European journal of pharmacology

authors： Ziomek G,Cheraghi Zanjani P,Arman D,van Breemen C,Esfandiarei M

更新日期：2014-07-15 00:00:00

abstract：:Experiments were performed in isolated guinea pig hearts, perfused at constant volume. Left ventricular pressure, left ventricular dp/dtmax, coronary vascular pressure and coronary venous pO2 were measured continuously. Indomethacin (1.4 X 10(-6) M) increased coronary vascular resistance by 15% over control (p less th...

journal_title：European journal of pharmacology

authors： Schrör K,Krebs R,Nookhwun C

更新日期：1976-09-01 00:00:00

abstract：:The effect of carbachol (10(-3)M) on the membrane potential of rat diaphragm muscle fibres near and remote from the endplate has been investigated by means of a microelectrode technique. In the endplate region a rather slow depolarization was observed followed by spontaneous repolarization. Outside the endplate region...

journal_title：European journal of pharmacology

authors： Mooij JJ,Evers CD,Ras R

更新日期：1976-06-01 00:00:00

abstract：:The aims of the present study were to examine the effect of adenosine monophosphate-activated protein kinase (AMPK) activation on airway smooth muscle cells (ASMCs) proliferation and to address its potential mechanisms. Platelet derived growth factor (PDGF) activated phosphatidylinositol 3-kinase (PI3K)/protein kinase...

journal_title：European journal of pharmacology

authors： Liu L,Pan Y,Song Y,Su X,Ke R,Yang L,Gao L,Li M

更新日期：2016-11-15 00:00:00

abstract：:The effect of estrogen on neointimal formation in injured rat arteries has been reported to be a sexual dimorphic effect. Recently, it has been reported that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) exhibit vasoprotective effects, which are independent of their cholesterol-lowerin...

journal_title：European journal of pharmacology

authors： Kurumazuka D,Mori T,Matsumoto N,Shirakawa H,Kimura S,Nakano D,Hayashi T,Kitaura Y,Matsumura Y

更新日期：2006-12-28 00:00:00

abstract：:Inhibitors of the metabolism of the endogenous cannabinoid ligand anandamide by fatty acid amide hydrolase (FAAH) reduce the gastric damage produced by non-steroidal anti-inflammatory agents and synergise with them in experimental pain models. This motivates the design of compounds with joint FAAH/cyclooxygenase (COX)...

journal_title：European journal of pharmacology

authors： Cipriano M,Björklund E,Wilson AA,Congiu C,Onnis V,Fowler CJ

更新日期：2013-11-15 00:00:00

abstract：:The effects of procaine, mepivacaine and phenylbutazone on pain perception in the equine were studied using two behavioral assays of nociception; the thermal evoked hoof withdrawal reflex and skin twitch reflex. Pain perception threshold was measured as the latency from onset of thermal stimuli to reflex withdrawal of...

journal_title：European journal of pharmacology

authors： Kamerling SG,Dequick DJ,Weckman TJ,Sprinkle FP,Tobin T

更新日期：1984-12-15 00:00:00

abstract：:The in vivo and in vitro effects of melatonin on enzyme activity of glutathione reductase (Glutathione: NADP(+) oxidoreductase, EC 1.8.1.7; GR) were investigated in this study. Glutathione reductase was purified from human erythrocytes 5.823-fold with a yield of 24% by ammonium sulfate fractionation, affinity chromato...

journal_title：European journal of pharmacology

authors： Erat M,Ciftci M

更新日期：2006-05-10 00:00:00

abstract：:The aim of this study was to examine the therapeutic effect of oxymatrine, a monomer isolated from the medicinal plant Sophora flavescens Ait, on the hepatic lipid metabolism in non-alcoholic fatty liver (NAFLD) rats and to explore the potential mechanism. Rats were fed with high fructose diet for 8 weeks to establish...

journal_title：European journal of pharmacology

authors： Shi LJ,Shi L,Song GY,Zhang HF,Hu ZJ,Wang C,Zhang DH

更新日期：2013-08-15 00:00:00

abstract：:Nausea and vomiting are among the most frequently occurring symptoms observed by clinicians. While advances have been made in understanding both the physiological as well as the neurophysiological pathways involved in nausea and vomiting, the final common pathway(s) for emesis have yet to be defined. Regardless of the...

journal_title：European journal of pharmacology

authors： Babic T,Browning KN

更新日期：2014-01-05 00:00:00

abstract：:Selective L-type voltage-operated calcium channel (VOCC) antagonists nicardipine, diltiazem and verapamil all produced pronounced falls in mean arterial blood pressure (MAP) in the anaesthetized artificially ventilated guinea-pig. This fall in MAP was associated with a significant reduction of the pressor response ind...

journal_title：European journal of pharmacology

authors： Bond A,Boot JR

更新日期：1992-07-21 00:00:00

abstract：:The main goal of this project was to study the effect of amiodarone upon ventricular fibrillation and defibrillation thresholds (VFT and VDT) in the canine heart under normal and ischemic conditions. Both parameters were assessed in 11 dogs, each experiment consisting of three consecutive phases: (a) control, which re...

journal_title：European journal of pharmacology

authors： Arredondo MT,Guillen SG,Quinteiro RA

更新日期：1986-06-05 00:00:00

abstract：:Coronary microembolization (CME) is responsible for a substantial fraction of microvascular obstruction (MVO), which are strongly associated with mortality and hospitalization for heart failure within 1 year after primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI). H...

journal_title：European journal of pharmacology

authors： Zhu HH,Wang XT,Sun YH,He WK,Liang JB,Mo BH,Li L

更新日期：2019-07-15 00:00:00

abstract：:The alpha1-adrenoceptor subtypes of rat prostate were characterized in binding and functional experiments. In binding experiments, [3H]tamsulosin bound to a single class of binding sites with an affinity (pKD) of 10.79+/-0.04 and Bmax of 87+/-2 fmol mg(-1) protein. This binding was inhibited by prazosin, 2-(2,6-dimeth...

journal_title：European journal of pharmacology

authors： Hiraoka Y,Ohmura T,Oshita M,Watanabe Y,Morikawa K,Nagata O,Kato H,Taniguchi T,Muramatsu I

更新日期：1999-01-29 00:00:00

abstract：:Recombinant human GABA(A) receptors were investigated in vitro by coexpression of cDNAs coding for alpha1, beta2, and gamma2 subunits in the baculovirus/Sf-9 insect cell system. We report that a single amino acid exchange (isoleucine 121 to valine 121) in the N-terminal, extracellular part of the alpha1 subunit induce...

journal_title：European journal of pharmacology

authors： Westh-Hansen SE,Rasmussen PB,Hastrup S,Nabekura J,Noguchi K,Akaike N,Witt MR,Nielsen M

更新日期：1997-06-25 00:00:00

abstract：:Oxidative stress is usually considered as an important factor to the pathogenesis of various diseases. Peroxynitrite (ONOO(-)) and hypochlorite (OCl(-)) are formed in immune cells as a part of the innate host defense system, but excessive reactive oxygen species generation can cause progressive inflammation and tissue...

journal_title：European journal of pharmacology

authors： Ren X,Ding Y,Lu N

更新日期：2016-03-15 00:00:00

abstract：:We have reported that neutrophil infiltration into gastric mucosa is closely related to gastric mucosal lesion development in rats with water immersion restraint stress. In this study, we examined the effect of teprenone, which is known to prevent gastric mucosal injury through stimulation of gastric mucus synthesis a...

journal_title：European journal of pharmacology

authors： Nishida K,Ohta Y,Ishiguro I

更新日期：1998-07-31 00:00:00

abstract：:Endothelium injury is a primary event in atherogenesis, which is followed by monocyte infiltration, macrophage differentiation, and smooth muscle cell migration. Peroxisome proliferator-activated receptors (PPARs) are transcription factors now recognized as important mediators in the inflammatory response. The aim of ...

journal_title：European journal of pharmacology

authors： Rival Y,Benéteau N,Taillandier T,Pezet M,Dupont-Passelaigue E,Patoiseau JF,Junquéro D,Colpaert FC,Delhon A

更新日期：2002-01-25 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic parameters of the selective serotonin reuptake inhibitor 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-5-phtalancarbonitril (citalopram) were determined in order to find optimal conditions for augmentation of its effect on extracellular serotonin [5-hydroxytryptamine (5-HT)] through ...

journal_title：European journal of pharmacology

authors： Cremers TI,de Boer P,Liao Y,Bosker FJ,den Boer JA,Westerink BH,Wikström HV

更新日期：2000-05-26 00:00:00

abstract：:Colorectal cancer (CRC) has become one of the major factors of tumor-related morbidity and mortality in the world because of its poor prognosis and consequences of metastatic spread. Currently, chemoprevention has been considered as a way of preventing cancer who takes advantage of plant phytochemicals and synthetic c...

journal_title：European journal of pharmacology

authors： Zhu Y,Yang Q,Liu H,Song Z,Chen W

更新日期：2020-11-15 00:00:00

abstract：:Acute dystonic reactions are motor side effects that occur soon after the initiation of neuroleptic treatment. Although earlier studies indicate that these abnormal movements can be induced in animals and humans via activation of sigma receptors, the relative contribution of the different sigma receptor subtypes is un...

journal_title：European journal of pharmacology

authors： Matsumoto RR,Pouw B

更新日期：2000-08-04 00:00:00

abstract：:Following pretreatment with 6-OH-dopamine, the sympathetic nerve endings of the iris and skeletal muscle of mice and rats were not longer detectable by cytochemistry for noradrenaline. In the same animals, the specific binding of [3H] ouabain to intact soleus muscles was not significantly different from that measured ...

journal_title：European journal of pharmacology

authors： Clausen T,Hansen O,Larsson LI

更新日期：1981-07-10 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is commonly seen in patients undergoing major surgeries and may persist. Although neuroinflammation is one of the important contributors to the development of POCD, the mechanisms underlying POCD remain unclear. We performed stabilized tibial fracture operation in male mice. ...

journal_title：European journal of pharmacology

authors： Wang T,Zhu H,Hou Y,Gu W,Wu H,Luan Y,Xiao C,Zhou C

更新日期：2019-03-05 00:00:00

abstract：:Nitric oxide (NO) is continuously produced in the lung and can be measured in exhaled gas of different species. To investigate a possible neuro-humoral regulation of pulmonary NO production in vivo we injected veratrine, an activator of Na(+) channels known to activate the sympathoadrenal system, in anaesthetized, mec...

journal_title：European journal of pharmacology

authors： Adding LC,Agvald P,Artlich A,Gustafsson LE

更新日期：2001-01-12 00:00:00

abstract：:Troglitazone has recently been introduced in the treatment of Type 2 diabetes. In addition to its anti-diabetic effects it acts as a perixosome proliferator activated receptor-gamma (PPAR-gamma) agonist and has anti-inflammatory properties by inhibiting macrophage tumour necrosis factor-alpha (TNF-alpha) secretion. It...

journal_title：European journal of pharmacology

authors： Beales PE,Liddi R,Giorgini AE,Signore A,Procaccini E,Batchelor K,Pozzilli P

更新日期：1998-09-18 00:00:00

abstract：:Plants are a natural source of bioactive compounds such as secondary metabolites. These molecules, also called phytochemicals, are fundamental for plant survival and often show therapeutic properties used for the treatment of human diseases. Asperuloside is a secondary metabolite which belongs to iridoid glycosides an...

journal_title：European journal of pharmacology

authors： Manzione MG,Martorell M,Sharopov F,Bhat NG,Kumar NVA,Fokou PVT,Pezzani R

更新日期：2020-09-15 00:00:00

abstract：:We have developed a model of ischaemia-reperfusion injury in C57BL/6 mice involving ischaemia for 0.5 to 2.5 h with an elastic tourniquet on one hind limb and reperfusion for 24 h, analogous to a well-established model of ischaemia-reperfusion injury in the rat. Viability was assessed in tissue homogenates of the gast...

journal_title：European journal of pharmacology

authors： Knight KR,Zhang B,Morrison WA,Stewart AG

更新日期：1997-08-13 00:00:00