Abstract：
:The metabolic syndrome is a cluster of more or less related metabolic and cardiovascular derangements including visceral obesity, insulin resistance, blood and tissue dislipidemia, high blood pressure and it is often associated with neuroendocrine and immunological dysregulations. The aetiology of this syndrome is clinically highly relevant because it predisposes to life-threatening complications, such as Diabetes Mellitus, kidney failure, cardiovascular disease, and certain types of cancer. Contributing factors include a sedentary life-style combined with increased dietary fat intake and psychosocial stress. From a biological viewpoint, however, the metabolic syndrome can be considered as a maladaptive consequence of an initially successful adaptation to high environmental demands. As opposed to pre-historic times - when environmental demands were usually energy-costly (e.g., fight/flight/hunt) and nutritional resource often inadequate - energy-utilizing actions serve no longer an optimal solution to deal with environmental demands of current human society. This paper describes the interactions between psychosocial stress and nutrition and how these may affect emotional and metabolic components of the metabolic syndrome. A deeper understanding of these interactions is necessary to come to effective treatment and prevention of the metabolic syndrome in the future.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
van Dijk G,Buwalda Bdoi
10.1016/j.ejphar.2007.11.079subject
Has Abstractpub_date
2008-05-06 00:00:00pages
137-46issue
1eissn
0014-2999issn
1879-0712pii
S0014-2999(08)00222-7journal_volume
585pub_type
杂志文章,评审abstract：:Vagal motor outflow from the dorsal vagal complex is important in the regulation of intestinal motility. The aim of our study was to test the hypothesis that within the dorsal vagal complex, tonic GABA(A)-receptor mediated neurotransmission modulates intestinal motility. The GABA(A) receptor antagonist, bicuculline (m...
journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
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abstract：:Dextromethorphan which is an active ingredient in many cough medicines has been previously shown to potentiate amnesic effect of morphine in rats. However, the effect of dextromethorphan, that is also a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, in combination with morphine on hippocampus-based lo...
journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(93)90357-n
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2016.11.048
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(88)90836-9
更新日期：1988-07-26 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2004.03.028
更新日期：2004-04-26 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/s0014-2999(97)01566-5
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abstract：:Rats were treated with 10 mg/kg tetrahydroaminoacridine (THA) twice daily for 14 days. THA (10 mg/kg) induced a significant decrease in the number of muscarinic receptors (both M1 and M2) in the cortex and striatum, whereas the number of nicotinic receptors in the cortex and hippocampus increased. Rats treated with ph...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(90)90448-f
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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doi：10.1016/j.ejphar.2008.10.048
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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doi：10.1016/j.ejphar.2004.04.011
更新日期：2004-06-16 00:00:00
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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doi：10.1016/j.ejphar.2006.06.062
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(95)00679-6
更新日期：1995-12-12 00:00:00
abstract：:Intrinsic drug resistance occurs in many renal carcinomas and is associated with increased expression of multidrug resistant proteins, which inhibits intracellular drug accumulation. Multidrug resistant protein 1, also known as P-glycoprotein, is a membrane drug efflux pump belonging to the ATP-binding cassette (ABC) ...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2014.11.021
更新日期：2015-01-05 00:00:00
abstract：:Platelet aggregation induced in mice or rats by i.v. ADP can be antagonized by oral administration of suloctidil. This effect on platelet behaviour appears to be sufficient to reduce the rate of thrombotic occlusion of the femoral artery in the dog and to protect the rat against occurrence of thrombophlebitis. ...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(76)90034-0
更新日期：1976-06-01 00:00:00
abstract：:It has been documented cardiac fibroblasts as the predominant cell population undergoing senescence in heart. Calcitonin gene-related peptide (CGRP) exhibits a wide range of cardiovascular protective effects. Whether CGRP protects against cardiac fibroblasts senescence in cardiac fibrosis remains unknown. Here, we det...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2018.10.023
更新日期：2019-01-15 00:00:00
