Brivaracetam and seletracetam, two new SV2A ligands, improve paroxysmal dystonia in the dt sz mutant hamster.

Abstract:

:Previous examinations demonstrated antidystonic effects of the synaptic vesicle protein 2A (SV2A) ligand levetiracetam in the dt(sz) mutant hamster, an animal model of paroxysmal non-kinesiogenic dyskinesia in which dystonic episodes can be induced by stress. In the present study, we examined the effects of the two new, high affinity SV2A ligands, brivaracetam and seletracetam, in comparison to levetiracetam on the severity of dystonia in mutant hamsters. Seletracetam (50 and 75 mg/kg i.p.) and brivaracetam (75 mg/kg i.p.) reduced the severity of dystonia to a comparable extent as levetiracetam (50 and 75 mg/kg i.p.). These data confirm the therapeutic potential of these pyrrolidone derivatives for the treatment of paroxysmal dystonia.

journal_name

Eur J Pharmacol

authors

Hamann M,Sander SE,Richter A

doi

10.1016/j.ejphar.2008.10.048

subject

Has Abstract

pub_date

2008-12-28 00:00:00

pages

99-102

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(08)01098-4

journal_volume

601

pub_type

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