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Adenosine A2A receptor stimulation enhances striatal extracellular glutamate levels in rats.

Abstract：

:The influence of CGS 21680, an adenosine A2A receptor agonist, on striatal glutamate extracellular levels was tested in a microdialysis study in rats. CGS 21680 (10 mu M), infused intrastriatally through the microdialysis probe, greatly enhanced glutamate extracellular levels. These results show that striatal adenosine A2A receptors are involved in the regulation of striatal glutamate extracellular levels. They also suggest that adenosine A2A receptor antagonists may possess neuroprotective effects in models of striatal excitotoxicity.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Popoli P,Betto P,Reggio R,Ricciarello G

doi

10.1016/0014-2999(95)00679-6

subject

Has Abstract

pub_date

1995-12-12 00:00:00

pages

215-7

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(95)00679-6

journal_volume

287

pub_type

杂志文章

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