Separate receptors mediating the positive inotropic and chronotropic effect of histamine in guinea-pig atria.

Abstract:

:The direct positive inotropic effect of histamine was studied on paced left atrial preparation from guinea pigs. Histamine (10(-8) to 10(-4) M) increased the maximum tension developed in left atria incubated at 35degreesC and driven at 2 Hz. The maximum increase in tension was 60% of that observed with norepinephrine. Metiamide (3 X 10(-5) M, a specific H2-receptor antagonist) did not alter the inotropic response of left atria to histamine. However, tripelennamine (a typical H1-receptor antagonist) competitively shifted the histamine inotropic dose--response curve to the right at concentrations from 10(-8) to 10(-7) M. Higher concentrations (3 X 10(-7) and 10(-6) M) caused little further additional shift to the right. The positive chronotropic effect of histamine on spontaneously beating atria was competitively antagonized by metiamide (10(-6) and 3 X 10(-6) M). These results demonstrate that in guinea-pig atria histamine increases myocardial contractility by an interaction with receptors closely related to classical H1-receptors while its chronotropic effect is mediated by interaction with H2-receptors.

journal_name

Eur J Pharmacol

authors

Steinburg MI,Holland DR

doi

10.1016/0014-2999(75)90229-0

keywords:

subject

Has Abstract

pub_date

1975-11-01 00:00:00

pages

95-104

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(75)90229-0

journal_volume

34

pub_type

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