Action of calcitonin gene-related peptide on rat aortic smooth muscle.

abstract：:In rat carotid arteries isolated 2 weeks after balloon denudation, a significant neointima developed with little change in medial size. Associated with this neointimal hyperplasia was a marked decrease in contraction to various agents including angiotensins I and II, big endothelin-1, endothelin-1, norepinephrine, phe...

journal_title：European journal of pharmacology

authors： Antonaccio MJ,Normandin D,Ferrer P

更新日期：1994-04-11 00:00:00

abstract：:We investigated the effects of antithrombin, a plasma inhibitor of coagulation factors, in rats with puromycin aminonucleoside-induced nephrosis, which is an experimental model of human nephrotic syndrome. Antithrombin (50 or 500 IU/kg/i.v.) was administered to rats once a day for 10 days immediately after the injecti...

journal_title：European journal of pharmacology

authors： Yamashita J,Nakajima K,Ohno Y,Kaneshiro Y,Matsuo T,Tanaka H,Kaneko K

更新日期：2008-07-28 00:00:00

abstract：:Mitiglinide (KAD-1229), a new anti-diabetic drug, is thought to stimulate insulin secretion by closing the ATP-sensitive K+ (K(ATP)) channels in pancreatic beta-cells. However, its selectivity for the various K(ATP) channels is not known. In this study, we examined the effects of mitiglinide on various cloned K(ATP) c...

journal_title：European journal of pharmacology

authors： Sunaga Y,Gonoi T,Shibasaki T,Ichikawa K,Kusama H,Yano H,Seino S

更新日期：2001-11-09 00:00:00

abstract：:Ischemia/reperfusion injury ends up in the cascade of excitotoxic stimulation of superoxide and nitric oxide formation leading to the generation of highly reactive products, including peroxinitrite and hydroxyl radical, which are capable of damaging lipids, proteins and DNA. Several polyphenolic compounds scavenge the...

journal_title：European journal of pharmacology

authors： ArunaDevi R,Lata S,Bhadoria BK,Ramteke VD,Kumar S,Sankar P,Kumar D,Tandan SK

更新日期：2010-01-25 00:00:00

abstract：:We aimed to determine the presence of oxidative stress in rhinitis medicamentosa (RM) and to evaluate the effect of erdosteine (ED) on mucosal changes in a rat model. Twenty-four male rats were used in this experimental study. Three groups were created. Group 1 (n=8) was the control group. Two puffs of 0.05% oxymetazo...

journal_title：European journal of pharmacology

authors： Dokuyucu R,Cevik C,Ozler GS,Ozgur T,Arli C,Sefil F,Yonden Z

更新日期：2014-11-05 00:00:00

abstract：:The present study was performed to clarify the mechanism of change in intraocular pressure by 2-(1-hexyn-1-yl)adenosine (2-H-Ado), a selective adenosine A2 receptor agonist, in rabbits. 2-H-Ado (0.1%, 50 microl)-induced ocular hypertension (E(max): 7.7 mm Hg) was inhibited by an adenosine A2A receptor antagonist 1,3,7...

journal_title：European journal of pharmacology

authors： Konno T,Uchibori T,Nagai A,Kogi K,Nakahata N

更新日期：2005-08-22 00:00:00

abstract：:H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) is a compound characterized in vitro as a potent and selective inhibitor of protein kinase A (PKA). In this study, we found that H89 reduced the phosphorylation of the myosin regulatory light chain (MRLC) at Thr-18/Ser-19 and induced disassembly of stre...

journal_title：European journal of pharmacology

authors： Umeda D,Yamada K,Tachibana H

更新日期：2008-08-20 00:00:00

abstract：:Ethanol (160-640 mM) produces a biphasic action on the indirectly stimulated rat phrenic nerve--diaphragm preparation. This consists of a potentiation followed by a blockade of muscle contraction. Concomitant with the increase in the force of contraction was the appearance of multiple neural action potentials recorded...

journal_title：European journal of pharmacology

authors： Cooper SA,Dretchen KL

更新日期：1975-04-01 00:00:00

abstract：:The inhibitory action of bicyclic isoxazole gamma-aminobutyric acid (GABA) analogues and their 4,4-diphenyl-3-butenyl (DPB) substituted derivatives has been investigated in cortical neurones and astrocytes as well as in human embryonic kidney (HEK 293) cells transiently expressing either mouse GABA transporter-1 (GAT-...

journal_title：European journal of pharmacology

authors： Bolvig T,Larsson OM,Pickering DS,Nelson N,Falch E,Krogsgaard-Larsen P,Schousboe A

更新日期：1999-06-30 00:00:00

abstract：:Radioligand receptor binding techniques were used to characterize the effects of different structural types of antidepressant drugs on neurotransmitter receptors. The tricyclic antidepressants more or less potently inhibited the binding to rat brain preparations of several different radiolabelled ligands [3H]WB4101, [...

journal_title：European journal of pharmacology

authors： Hall H,Ogren SO

更新日期：1981-03-26 00:00:00

abstract：:Compound (+)-R,R-D-84 is an optically active trans-hydroxy-substituted derivative of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine (D-164). As a hydroxypiperidine analog of GBR 12935, (+)-R,R-D-84 is a candidate dopamine transporter compound for the treatment of cocaine dependence. The present work addresses ...

journal_title：European journal of pharmacology

authors： Zhen J,Maiti S,Chen N,Dutta AK,Reith ME

更新日期：2004-12-03 00:00:00

abstract：:DSP-4 (N-(2-chloroethyl)-ethyl-2-bromobenzylamine) a novel neurotoxin which destroys central noradrenaline neurones after peripheral injection was administered to rats (50 mg/kg X 2). This procedure did not alter activity responses to quipazine (7.5 mg/kg) or apomorphine (0.2 mg/kg) but prevented their enhancement by ...

journal_title：European journal of pharmacology

authors： Heal DJ,Davies CL,Goodwin GM

更新日期：1985-09-10 00:00:00

abstract：:In cystic fibrosis respiratory epithelial cells, the absence or dysfunction of the chloride channel CFTR (Cystic Fibrosis Transmembrane conductance Regulator) results in reduced chloride ion transport. In contrast, Ca2+-stimulated Cl- secretion is intact in cystic fibrosis airway epithelia. One possible target for dru...

journal_title：European journal of pharmacology

authors： Norez C,Vandebrouck C,Antigny F,Dannhoffer L,Blondel M,Becq F

更新日期：2008-09-11 00:00:00

abstract：:Synaptosomal membranes from cat cerebral cortex were labelled with [3H]-quinuclidinyl benzylate ([3H]QNB). There was shown to be a single type of binding site with Kd = 0.34 nM, Bmax = 2.2 nmol/g protein and Hill No. = 1.01. Triton X-100 at 5 x 10(-4)% inhibited the specific binding of [3H]QNB and the inhibition was a...

journal_title：European journal of pharmacology

authors： Aguilar JS,Criado M,De Robertis E

更新日期：1980-05-16 00:00:00

abstract：:The effects of the new 3,4-disubstituted furoxan, CHF 2206, on vascular tone, platelet aggregation and platelet cyclic 3',5'-guanosine monophosphate (cGMP) levels were investigated. The compound was a potent inhibitor of rabbit aortic ring contraction induced by norepinephrine, the stable prostaglandin F2 alpha analog...

journal_title：European journal of pharmacology

authors： Civelli M,Caruso P,Giossi M,Bergamaschi M,Razzetti R,Bongrani S,Gasco A

更新日期：1994-04-01 00:00:00

abstract：:The cellular localisation and distribution of mRNAs encoding beta-adrenoceptor subtypes in human lung were studied by in situ hybridisation and Northern blot analysis. The 851-bp SmaI/PvuII fragment of human beta 1-adrenoceptor cDNA, the 439-bp SmaI fragment of human beta 2-adrenoceptor cDNA and the 975-bp SmaI fragme...

journal_title：European journal of pharmacology

authors： Mak JC,Nishikawa M,Haddad EB,Kwon OJ,Hirst SJ,Twort CH,Barnes PJ

更新日期：1996-04-29 00:00:00

abstract：:Substance P causes histamine release from rat peritoneal mast cells probably through direct activation of a specific G protein at micromolar concentrations. We found that peritoneal mast cells of a substrain of Wistar rats (Std:Wistar) responds to nanomolar concentrations of substance P by releasing histamine in a con...

journal_title：European journal of pharmacology

authors： Ogawa K,Nabe T,Yamamura H,Kohno S

更新日期：1999-06-18 00:00:00

abstract：:We have previously demonstrated that the n-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) has an antinociceptive effect on various pain stimuli in a naloxone-reversible manner. In the present study, the role of the endogenous opioid peptide β-endorphin in DHA-induced antinociception was examined. DHA-induced ...

journal_title：European journal of pharmacology

authors： Nakamoto K,Nishinaka T,Ambo A,Mankura M,Kasuya F,Tokuyama S

更新日期：2011-09-01 00:00:00

abstract：:cRNA encoding the human IsK protein was injected into Xenopus oocytes and the expressed channels were investigated using the two-microelectrode voltage-clamp method. The novel class III antiarrhythmic NE-10064 (1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]-amino]-3- [4-(4-methyl-1-piperazinyl)-butyl]-2,4-imidazolidined...

journal_title：European journal of pharmacology

authors： Busch AE,Herzer T,Takumi T,Krippeit-Drews P,Waldegger S,Lang F

更新日期：1994-10-13 00:00:00

abstract：:The effects of itasetron (endo-N-8-methyl-8-azabicyclo-[3.2.1.]-octo-3-yl) -2,3-dihydro-2-oxo-1 H-benzimidazole-1-carboxamide hydrochloride), a 5-HT3 receptor antagonist, on discrete memory abilities of the aged rat were assessed by using the multiple choice avoidance behavioral task. Chronic treatment with itasetron ...

journal_title：European journal of pharmacology

authors： Pitsikas N,Borsini F

更新日期：1996-09-12 00:00:00

abstract：:We examined the effect of HSR-81 ((-)-(R)-alpha-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol L-tartrate), a newly developed, potent and selective beta 2-adrenoceptor agonist, as well as ritodrine and isoproterenol, on the spontaneous rhythmic contraction in uteri isolated from late pregnant, middle pregn...

journal_title：European journal of pharmacology

authors： Ohashi T,Hashimoto S,Morikawa K,Kato H,Ito Y,Asano M,Azuma H

更新日期：1996-07-04 00:00:00

abstract：:The effects of local application of a cream containing nitric oxide (NO) donors, S-nitroso-N-acetylpenicillamine (SNAP) or isosorbide dinitrate were studied in a rat model of incision pain. An incision was made in the plantar aspect of a hind paw and the cream was applied inside the surgical wound. SNAP (1-10%) or iso...

journal_title：European journal of pharmacology

authors： Prado WA,Schiavon VF,Cunha FQ

更新日期：2002-04-19 00:00:00

abstract：:Our goal was to determine if venlafaxine has a negative effect on bone metabolism. Rats were divided into three groups. The sham-operated control group (SHAM), the control group after orchidectomy (ORX), and the experimental group after orchidectomy received venlafaxine (VEN ORX) in standard laboratory diet (SLD) for ...

journal_title：European journal of pharmacology

authors： Fekete S,Simko J,Mzik M,Karesova I,Zivna H,Zivny P,Pavliková L,Palicka V

更新日期：2015-08-15 00:00:00

abstract：:In type 1 diabetes, there is a rapid loss of glycemic control immediately after onset of the disease. We aimed to determine if the deterioration of glycemic control that occurs early after the onset of insulin-deficient diabetes could be blunted by treatment with recombinant fibroblast growth factor 21 (FGF21). Normal...

journal_title：European journal of pharmacology

authors： Andersen B,Omar BA,Rakipovski G,Raun K,Ahrén B

更新日期：2015-10-05 00:00:00

abstract：:We have investigated the effect of inhaled HOE 140, a novel bradykinin B2 receptor antagonist, against bradykinin- and vagal stimulation-induced airway microvascular leakage and bronchoconstriction in anesthetized guinea-pigs. Lung resistance was measured for 6 min after challenge, followed by measurement of extravasa...

journal_title：European journal of pharmacology

authors： Sakamoto T,Sun J,Barnes PJ,Chung KF

更新日期：1994-01-14 00:00:00

abstract：:Cyclophosphamide (CPA) is a chemotherapeutic drug widely used in the treatment of breast cancer or leukemia in clinic. However, CPA was reported to have hepatotoxicity. This study aims to observe the engaged mechanism of CPA-induced liver injury in mice and the protection of liquiritin (LQ) and liquiritigenin (LG). Li...

journal_title：European journal of pharmacology

authors： Chen M,Zhang C,Zhang J,Kai G,Lu B,Huang Z,Ji L

更新日期：2019-08-05 00:00:00

abstract：:Exposure of cultured heart muscle cells to noradrenaline led to a decrease in the effects of isoproterenol and prostaglandin E1 on cAMP formation and contraction velocity. However, heterologous desensitization, as measured by prostaglandin E1 stimulation, only occurred at higher noradrenaline concentrations than homol...

journal_title：European journal of pharmacology

authors： Reithmann C,Werdan K

更新日期：1988-09-01 00:00:00

abstract：:Nitric oxide can exert either protective or damaging effects on the gastric mucosa. To further explore the role of nitric oxide in the modulation of gastric mucosal defense, the effects of intra-arterial administration of the precursor, L-arginine, on susceptibility of the gastric mucosa to damage induced by topically...

journal_title：European journal of pharmacology

authors： Ferraz JG,Tigley A,Wallace JL

更新日期：1994-07-21 00:00:00

abstract：:Many of the physiological responses to nitric oxide (NO) are mediated by cyclic 5'-guanosine monophosphate (cGMP), the intracellular levels of which are regulated by phosphodiesterase type 5 (PDE5). In situations of reduced NO formation, the inhibition of PDE5 by selective inhibitors such as sildenafil could be benefi...

journal_title：European journal of pharmacology

authors： Ferreira-Melo SE,Yugar-Toledo JC,Coelho OR,De Luca IM,Tanus-Santos JE,Hyslop S,Irigoyen MC,Moreno H Jr

更新日期：2006-08-07 00:00:00

abstract：:This study examined the potential of the selective extra-synaptic α5-GABAA receptor inhibitor S44819 (Egis-13529) to improve cognitive performance in preclinical models of vascular cognitive impairment (VCI). Chronic hypoperfusion of the brain in mice was induced by permanent occlusion of the right common carotid arte...

journal_title：European journal of pharmacology

authors： Gacsályi I,Móricz K,Gigler G,Megyeri K,Machado P,Antoni FA

更新日期：2018-09-05 00:00:00