Itasetron (DAU 6215) prevents age-related memory deficits in the rat in a multiple choice avoidance task.

abstract：:In the rat substantia nigra Type II benzodiazepine recognition sites (measured as the portion of [3H]flunitrazepam binding which remain after the addition of 2 X 10(-7) M Cl 218872) represent 50% of the total benzodiazepine recognition sites. The density of Type II sites was increased by 35% following the degeneration...

journal_title：European journal of pharmacology

authors： Porceddu ML,Corda MG,Sanna E,Biggio G

更新日期：1985-06-07 00:00:00

abstract：:The present study examined the adverse effects of delta-9-tetrahydrocannabinol (i.p injection in albino mice) on free radical damage of testicular lipids (lipid peroxidation) at low doses and the role of antioxidant enzymes defense system at high dose and particularly at the withdrawal of the drug after applying highe...

journal_title：European journal of pharmacology

authors： Mandal TK,Das NS

更新日期：2009-04-01 00:00:00

abstract：:A concentration-dependent relaxant effect of phentolamine was demonstrated in guinea-pig isolated trachea and was probably unrelated to its alpha-adrenoceptor blocking action. The maximal effect of phentolamine against spontaneous tracheal tone was in the 24-100% range. However, phentolamine produced 100% relaxation w...

journal_title：European journal of pharmacology

authors： Bang L,Nielsen-Kudsk JE

更新日期：1992-02-11 00:00:00

abstract：:Oxidative stress is recognized as an important factor in the development of liver pathologies. The reactive oxygen species endogenously generated or as a consequence of xenobiotic metabolism are eliminated by enzymatic and nonenzymatic cellular systems. Besides endogen defences, the antioxidant consumption in the diet...

journal_title：European journal of pharmacology

authors： Rubiolo JA,Mithieux G,Vega FV

更新日期：2008-09-04 00:00:00

abstract：:The effects of dopamine (DA) and of two selective DA DA1 agonists (SKF 38393 and SKF 82526) on adenylate cyclase activity were studied with human kidney cortex membrane preparations. DA elicited a dose-related stimulation of adenylate cyclase activity with an EC50 of 60 microM. The selective DA DA1 antagonist SCH 2339...

journal_title：European journal of pharmacology

authors： Baldi E,Pupilli C,Amenta F,Mannelli M

更新日期：1988-05-10 00:00:00

abstract：:The mechanisms underlying the capsaicin-induced relaxation of the acetylcholine- as well as KCl-contraction were studied by measuring isometric force and phosphorylation of 20-kDa regulatory light chain subunit of myosin (MLC(20)) in ileal longitudinal smooth muscles of rats. Capsaicin relaxed acetylcholine- and KCl-s...

journal_title：European journal of pharmacology

authors： Fujimoto S,Mori M

更新日期：2004-03-08 00:00:00

abstract：:A growing body of evidence supports an important role of the transcription factor cAMP responsive element binding protein (CREB) in mediating opioid-induced changes in the cAMP pathway. Regulation of CREB and subsequent changes in gene expression may underlie some long-term cellular adaptations associated with the adm...

journal_title：European journal of pharmacology

authors： Bilecki W,Höllt V,Przewłocki R

更新日期：2000-02-25 00:00:00

abstract：:The human cholecystokinin B (CCKB) receptor has been isolated from a human temporal cortex cDNA library. Transient transfection of the receptor into COS-M6 cells resulted in high specific binding of 125I-sulphated CCK-8 labelled with Bolton and Hunter Reagent (KD = 31 pM). Competition experiments yielded the expected ...

journal_title：European journal of pharmacology

authors： Denyer J,Gray J,Wong M,Stolz M,Tate S

更新日期：1994-06-15 00:00:00

abstract：:The spasmogenic activity of caffeine (10 mM) was evaluated in tracheal strips obtained from control and sensitized guinea-pigs then pretreated with indomethacin (2.8 microM) and cooled to 20 degrees C. The contraction elicited by caffeine was inhibited by verapamil (100 microM), trifluoperazine (100 and 500 microM) an...

journal_title：European journal of pharmacology

authors： Ortiz JL,Cortijo J,Morcillo EJ,Sanz C,Perpiñá M,Esplugues J

更新日期：1988-12-13 00:00:00

abstract：:Infusion of arachidonic acid through the guinea pig lung or the cat spleen causes a release of thromboxane A2 and prostaglandins, as measured by bioassay. After incubation of human platelets with arachidonate similar metabolites are formed, as demonstrated chromatographically. Infusion of imidazole (50-75 microgram/ml...

journal_title：European journal of pharmacology

authors： Nijkamp FP,Moncada S,White HL,Vane JR

更新日期：1977-07-15 00:00:00

abstract：:We studied beta-adrenoceptors by quantitative autoradiography in the cardiac vagus ganglia of the rat, after incubation of tissue sections with [125I]iodocyanopindolol. The cardiac vagus ganglia presented a high concentration of a single population of high affinity binding sites (Bmax 109 +/- 10 fmol/mg protein; Kd 64...

journal_title：European journal of pharmacology

authors： Saito K,Potter WZ,Saavedra JM

更新日期：1988-08-24 00:00:00

abstract：:Several experiments were conducted to study the effects of established or potential antiparkinsonian drugs on the tremulous jaw movements induced by the anticholinesterase tacrine (9-amino-1,2,3,4-tetrahydroaminoacridine hydrochloride). In the first group of four experiments, separate groups of animals that received 2...

journal_title：European journal of pharmacology

authors： Cousins MS,Carriero DL,Salamone JD

更新日期：1997-03-19 00:00:00

abstract：:Following pretreatment with 6-OH-dopamine, the sympathetic nerve endings of the iris and skeletal muscle of mice and rats were not longer detectable by cytochemistry for noradrenaline. In the same animals, the specific binding of [3H] ouabain to intact soleus muscles was not significantly different from that measured ...

journal_title：European journal of pharmacology

authors： Clausen T,Hansen O,Larsson LI

更新日期：1981-07-10 00:00:00

abstract：:The pharmacological actions of sotalol, (-)-propranolol and prazosin on norepinephrine (NE) concentration and creatine kinase (CK) activity in the coronary sinus blood of the ischemic heart were studied in open-chest dogs. A 60 min occlusion of the left anterior descending coronary artery was followed by a reperfusion...

journal_title：European journal of pharmacology

authors： Lamontagne D,Yamaguchi N,Nadeau R,De Champlain J,Godin D,Campeau N

更新日期：1986-04-09 00:00:00

abstract：:Three peptide components of atrial natriuretic factor (ANF) caused relaxation of carbachol-contracted guinea-pig isolated tracheal smooth muscle. These were the 1-28, 5-28 and 5-27 peptide sequences (ANF(1-28), ANF-(5-28) and ANF-(5-27)). The peptides were 10-30 times more potent in epithelium-denuded than in epitheli...

journal_title：European journal of pharmacology

authors： Fernandes LB,Preuss JM,Goldie RG

更新日期：1992-03-03 00:00:00

abstract：:Corticotropin-releasing factor (CRF) regulates the hypothalamic-pituitary-adrenal axis, coordinates the mammalian stress response, and acting primarily via the CRF(1) receptor, has been strongly implicated in the pathophysiology of depression and anxiety. Furthermore, the behavioral and autonomic activation that occur...

journal_title：European journal of pharmacology

authors： Skelton KH,Oren D,Gutman DA,Easterling K,Holtzman SG,Nemeroff CB,Owens MJ

更新日期：2007-09-24 00:00:00

abstract：:Canine femoral arteries responded to acetylcholine with relaxations; these were abolished in potassium free solution, restored by potassium or rubidium but not by cesium or amonium. Potassium and rubidium were equipotent in inducing ouabain-sensitive relaxation, while amonium and cesium were less potent. The results (...

journal_title：European journal of pharmacology

authors： De Mey J,Vanhoutte PM

更新日期：1980-10-03 00:00:00

abstract：:Sprague-Dawley rats were trained to discriminate a subcutaneous injection of physostigmine (0.2 mg/kg) from a similar injection of saline in a two-lever, food-reinforced behavior paradigm. The training dose of physostigmine reduced the response rate to about 50% of that in saline sessions. The discriminative stimulus ...

journal_title：European journal of pharmacology

authors： Tang AH,Franklin SR

更新日期：1988-08-09 00:00:00

abstract：:Only in the last few years has non-alcoholic steatohepatitis been recognized as an important and relatively common liver disease. To date, the therapeutic options are limited, vitamin E and metformin have been proposed for the treatment of this condition, although their mechanisms are not completely clarified as yet. ...

journal_title：European journal of pharmacology

authors： Raso GM,Esposito E,Iacono A,Pacilio M,Cuzzocrea S,Canani RB,Calignano A,Meli R

更新日期：2009-02-14 00:00:00

abstract：:Hydroxytyrosol (HT), a polyphenol widely contained as an ester in olive fruits and olive leaves, exhibits a broad spectrum of effectiveness. The present study was designed to investigate the effect of HT alone as well as in the combination with cisplatin on the House Ear Institute-Organ of Corti 1 cells (HEI-OC1) and ...

journal_title：European journal of pharmacology

authors： Zhang W,Man R,Yu X,Yang H,Yang Q,Li J

更新日期：2020-11-15 00:00:00

abstract：:A series of 26 drugs was tested for in vitro binding to opiate receptors in the presence and absence of 0.1 M NaCl. The results were correlated with assays for in vivo pharmacological potency. Highly significant correlation was found between binding in the presence and absence of sodium ions and analgesic potency. For...

journal_title：European journal of pharmacology

authors： Stahl KD,van Bever W,Janssen P,Simon EJ

更新日期：1977-12-01 00:00:00

abstract：:It has been shown that the pancreatic beta-cell monoamines are located in the secretory granules, and that they have an inhibitory influence on insulin secretion. Monoamines are inactivated by the enzyme, monoamine oxidase. We now studied in vivo the relation between adrenergic and cholinergic stimulation, insulin sec...

journal_title：European journal of pharmacology

authors： Panagiotidis G,Stenström A,Lundquist I

更新日期：1993-03-23 00:00:00

abstract：:Platinum resistance is a major limitation in the treatment of ovarian cancer. Combination of natural compounds with platinum-based agents is a new strategy for cancer chemotherapy. Recently, we found that scutellarin sensitized the anticancer effect of cisplatin to ovarian cancer cells. How scutellarin interacts with ...

journal_title：European journal of pharmacology

authors： Xie Z,Guo Z,Lei J,Yu J

更新日期：2019-02-05 00:00:00

abstract：:This study investigated sex-related differences in rat papillary muscle force generation in response to altered extracellular [Ca2+] ([Ca2+](o), 0.2 to 5.0 mM) and to L-type Ca2+ channel modulators (nifedipine and Bay K8644). At all [Ca2+]o examined, contractile force was significantly greater in male than female papi...

journal_title：European journal of pharmacology

authors： Curl CL,Delbridge LM,Wendt IR

更新日期：2008-05-31 00:00:00

abstract：:Intracerebroventricular injection of ethacrynic acid (50% convulsive dose; 50 micrograms/mouse) accelerated the synthesis/turnover of 5-hydroxytryptamine (5-HT) but suppressed the synthesis of gamma-aminobutyric acid and acetylcholine in mouse brain. These effects were completely antagonized by pretreatment with a glu...

journal_title：European journal of pharmacology

authors： Inoue M,Hirose T,Yasukura T,Inagaki C

更新日期：1992-10-06 00:00:00

abstract：:The [3H]nitrendipine binding activity of sarcolemmal fragments isolated from aerobically perfused or ischemic rat hearts was studied. After 90 min aerobic perfusion, two populations of binding sites were detected--high affinity sites with KD of 0.24 +/- 0.04 nM and Bmax 313 +/- 110 fmol/mg protein, and low affinity si...

journal_title：European journal of pharmacology

authors： Nayler WG,Dillon JS,Elz JS,McKelvie M

更新日期：1985-09-10 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is one of the risk factors for Parkinson's disease (PD). Insulin desensitisation has been observed in the brains of patients, which may promote neurodegeneration. Incretins are a family of growth factors that can re-sensitise insulin signalling. We have previously shown that mimetics of...

journal_title：European journal of pharmacology

authors： Yuan Z,Li D,Feng P,Xue G,Ji C,Li G,Hölscher C

更新日期：2017-10-05 00:00:00

abstract：:Thiorphan, the potent inhibitor of 'enkephalinase', has shown some analgesic properties in experimental animals and in man. The possibility that the intravenous infusion of acetorphan, a prodrug of thiorphan (26 micrograms/kg per min for 60 min), can inhibit plasma and cerebrospinal fluid (CSF) enkephalinase in man in...

journal_title：European journal of pharmacology

authors： Spillantini MG,Geppetti P,Fanciullacci M,Michelacci S,Lecomte JM,Sicuteri F

更新日期：1986-06-05 00:00:00

abstract：:The treatment of rat thymocytes with 10 microM terfenadine resulted in a significant increase in DNA fragmentation. The DNA fragmentation induced by terfenadine was dependent on its concentration and incubation time. In terfenadine-treated cells, the translocation of phosphatidylserine from the inside of plasma membra...

journal_title：European journal of pharmacology

authors： Enomoto R,Komai T,Yoshida Y,Sugahara C,Kawaguchi E,Okazaki K,Kinoshita H,Komatsu H,Konishi Y,Lee E

更新日期：2004-08-02 00:00:00

abstract：:All-night spectral analysis of the sleep EEG was used to study the effect and after-effect of a single bedtime dose of flunitrazepam (2 mg), flurazepam (30 mg) or triazolam (0.5 mg) in healthy young males. In the night of drug treatment all 3 hypnotics reduced the EEG slow waves and enhanced the activity in the freque...

journal_title：European journal of pharmacology

authors： Borbély AA,Mattmann P,Loepfe M,Fellmann I,Gerne M,Strauch I,Lehmann D

更新日期：1983-04-22 00:00:00