Quantitative autoradiography of beta-adrenoceptors in the cardiac vagus ganglia of the rat.


:We studied beta-adrenoceptors by quantitative autoradiography in the cardiac vagus ganglia of the rat, after incubation of tissue sections with [125I]iodocyanopindolol. The cardiac vagus ganglia presented a high concentration of a single population of high affinity binding sites (Bmax 109 +/- 10 fmol/mg protein; Kd 64 +/- 5 pM). Displacement studies with the beta 1-selective adrenoceptor antagonist CGP 20712 A and the beta 2-selective adrenoceptor antagonist ICI 118,551 indicated that most (80 to 90%) of the binding sites are of the beta 2-type.


Eur J Pharmacol


Saito K,Potter WZ,Saavedra JM




Has Abstract


1988-08-24 00:00:00














  • A study comparing the effects of rosiglitazone and/or insulin treatments on streptozotocin induced diabetic (type I diabetes) rat aorta and cavernous tissues.

    abstract::Our aim was to investigate the role of oxidative stress and inflammation on the functional and biochemical changes caused by hyperglycemia in the aorta and corpus cavernosum tissues of streptozotozin diabetic rats and to determine if rosiglitazone and/or insulin treatment has any preventive effect on organ dysfunction...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Elçioğlu HK,Kabasakal L,Özkan N,Çelikel Ç,Ayanoğlu-Dülger G

    更新日期:2011-06-25 00:00:00

  • Antinociceptive effect of some carboxypeptidase A inhibitors in comparison with D-phenylalanine.

    abstract::It had previously been shown that D-phenylalanine and hydrocinnamic acid, two in vitro inhibitors of carboxypeptidase A, possess an analgesic action when injected i.p. in mice. We have studied the in vivo effects of indole-3-acetic acid, another carboxypeptidase A inhibitor, and of the following analogs of D-phenylala...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Giusti P,Carrara M,Cima L,Borin G

    更新日期:1985-10-22 00:00:00

  • [3H]MDL 105,519 binds with equal high affinity to both assembled and unassembled NR1 subunits of the NMDA receptor.

    abstract::[3H]MDL 105,519 (((E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1[3H]-indole-2-ca rboxylic acid) is a novel radioligand which binds with high affinity, Kd = 2.5 nM, to the glycine site of adult rodent forebrain, N-methyl-D-aspartate subtype of glutamate receptors. As with other glycine site antagonists, the major det...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Chazot PL,Reiss C,Chopra B,Stephenson FA

    更新日期:1998-07-17 00:00:00

  • Effects of (+)-S-12967 and (-)-S-12968, two enantiomers of a new slow-acting 1,4-dihydropyridine, on rat coronary resistance arteries.

    abstract::The action of (+)-S-12967 and (-)-S-12968, two isomers of a new 1,4-dihydropyridine molecule (2-(-7-amino-2,5-dioxaheptyl)-3-ethoxycarbonyl-4-(2,3-dichlorop hen yl)-5-methoxycarbonyl-6-methyl 1,4-dihydropyridine), was studied on responses of rat isolated coronary resistance arteries (i.d. about 230 microns) to K+, Ca...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Prieto D,Mulvany MJ,Nyborg NC

    更新日期:1993-07-06 00:00:00

  • Intrathecal opioids block a spinal action of substance P in mice: functional importance of both mu- and delta-receptors.

    abstract::Inhibition of intrathecal substance P-elicited behavior by mu-, delta- and kappa-opioids was compared. In both the substance P behavioral test and the tail flick antinociceptive test, intrathecal [D-Ala2, Met5]enkephalinamide and [D-Ala2, D-Leu5]enkephalin (DADL) were equipotent, morphine and ethylketazocine were less...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Hylden JL,Wilcox GL

    更新日期:1982-12-17 00:00:00

  • Role of simvastatin and/or antioxidant vitamins in therapeutic angiogenesis in experimental diabetic hindlimb ischemia: effects on capillary density, angiogenesis markers, and oxidative stress.

    abstract::Therapeutic angiogenesis has emerged as an attractive approach for the management of peripheral arterial disease in diabetic patients. Oxidative stress generated and aggravated by prolonged hyperglycemia may interfere with and destroy the newly formed blood vessels. Angiogenic effect of simvastatin has been reported; ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: El-Azab MF,Hazem RM,Moustafa YM

    更新日期:2012-09-05 00:00:00

  • Effects of nor-binaltorphimine on the development of analgesic tolerance to and physical dependence on morphine.

    abstract::The effects of a highly selective kappa antagonist, nor-binaltorphimine (nor-BNI), on the development of tolerance to morphine analgesia and physical dependence on morphine were examined. Pretreatment with nor-BNI (5 mg/kg s.c.) 2 h prior to injection of morphine or a selective kappa agonist, U-50,488H, significantly ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Suzuki T,Narita M,Takahashi Y,Misawa M,Nagase H

    更新日期:1992-03-17 00:00:00

  • CNS site of antiarrhythmic action of diphenylhydantoin (DPH) in the cat.

    abstract::Diphenylhydantoin (DPH) is known to be a potent anticonvulsant agent, useful in treating and preventing grand mal seizures. More recently, DPH was reported also to be a potent antiarrhythmic agent acting by means of a depressant action on the heart. The present experiments demonstrated that DPH has also a potent antia...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Lisander B,Jaju B,Wang SC

    更新日期:1975-03-01 00:00:00

  • Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.

    abstract::Therapeutic angiogenesis is a promising strategy for treating ischemia. The lysophospholipid mediator sphingosine-1-phosphate (S1P) acts on vascular endothelial cells to stimulate migration and tube formation, and plays the critical role in developmental angiogenesis. We developed poly(lactic-co-glycolic-acid) (PLGA)-...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Qi X,Okamoto Y,Murakawa T,Wang F,Oyama O,Ohkawa R,Yoshioka K,Du W,Sugimoto N,Yatomi Y,Takuwa N,Takuwa Y

    更新日期:2010-05-25 00:00:00

  • Regulation of bradykinin receptor gene expression in human lung fibroblasts.

    abstract::In WI-38 human fibroblasts, interleukin-1 beta and tumour necrosis factor-alpha (TNF-alpha) increased bradykinin B(1) receptor mRNA, which peaked between 2 and 4 h, remaining elevated for 20 h. Binding of the bradykinin B(1) receptor selective ligand [3H]des-Arg(10)-kallidin, also increased, peaking at 4 h and remaini...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Phagoo SB,Yaqoob M,Herrera-Martinez E,McIntyre P,Jones C,Burgess GM

    更新日期:2000-06-02 00:00:00

  • Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2'-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice.

    abstract::We evaluated the effects of ACEA (selective cannabinoid (CB)1 receptor agonist), WIN 55,212-2 mesylate (WIN; non-selective CB1 and CB2 receptor agonist) and N-palmitoylethanolamine (PEA; an endogenous fatty acid of ethanolamide) in DBA/2 mice, a genetic model of reflex audiogenic epilepsy. PEA, ACEA or WIN intraperito...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Citraro R,Russo E,Leo A,Russo R,Avagliano C,Navarra M,Calignano A,De Sarro G

    更新日期:2016-11-15 00:00:00

  • Human brain imidazoline receptors: further characterization with [3H]clonidine.

    abstract::The aim of the present study was to further characterize [3H]clonidine binding in the ventrolateral medulla of the human brainstem, the region involved in the vasodepressor effect of imidazoline drugs of the clonidine type. Under basal conditions, [3H]clonidine can bind both to the imidazoline receptors and to the alp...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Bricca G,Greney H,Zhang J,Dontenwill M,Stutzmann J,Belcourt A,Bousquet P

    更新日期:1994-01-01 00:00:00

  • Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors.

    abstract::Peptides based in the stabilised tetrapeptide HTyr-D-Ala-Gly-MePheOH have been synthesised and shown to have substantial opioid activity both in vitro and in vivo. The selectivity of these compounds of different receptor populations has been investigated using both isolated tissue assays and binding studies. Results s...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Handa BK,Land AC,Lord JA,Morgan BA,Rance MJ,Smith CF

    更新日期:1981-04-09 00:00:00

  • Pharmacological characterization of release-regulating serotonin autoreceptors in rat cerebellum.

    abstract::The release of [3H]5-hydroxytryptamine ([3H]5-HT) evoked by 15 mM KCl in superfused rat cerebellum synaptosomes was inhibited by 5-HT (pEC30 = 8.73). Methiothepin antagonized 5-HT (pA2 = 9.28); ketanserin, methysergide, cinanserin and spiperone were ineffective. The receptors involved were activated (pEC30 = 8.90) by ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Bonanno G,Maura G,Raiteri M

    更新日期:1986-07-31 00:00:00

  • Amitriptyline enhances extracellular tissue levels of adenosine in the rat hindpaw and inhibits adenosine uptake.

    abstract::Local administration of amitriptyline into the rat hindpaw produces peripheral antinociception; this is reduced by adenosine receptor antagonists and appears to involve endogenous adenosine. The present study used peripheral microdialysis: (a) to determine whether amitriptyline could enhance extracellular tissue level...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Sawynok J,Reid AR,Liu XJ,Parkinson FE

    更新日期:2005-08-22 00:00:00

  • Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes.

    abstract::We have characterized the rat prostanoid EP1, EP2, EP3alpha and EP4 receptor subtypes cloned from spleen, hepatocyte and/or kidney cDNA libraries. Comparison of the deduced amino acid sequences of the rat EP receptors with their respective homologues from mouse and human showed 91% to 98% and 82% to 89% identity, resp...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Boie Y,Stocco R,Sawyer N,Slipetz DM,Ungrin MD,Neuschäfer-Rube F,Püschel GP,Metters KM,Abramovitz M

    更新日期:1997-12-11 00:00:00

  • The calcium channel agonist, Bay K 8644, inhibits renin release from rat kidney cortical slices.

    abstract::The effects of Bay K 8644 [methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) -pyridine-5-carboxylate], a calcium channel agonist, on renin release in rat kidney cortical slices were examined. Bay K 8644 produced a dose-related inhibition of renin release in the presence of 15 mM potassium. The inhibi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Matsumura Y,Sasaki Y,Shinyama H,Morimoto S

    更新日期:1985-11-19 00:00:00

  • Mitochondria, Ca2+ and neurodegenerative disease.

    abstract::Mitochondria play a central role in cell biology not only as producers of ATP, but also in the sequestration of Ca(2+) and the generation of free radicals. They are also repositories of several proteins which regulate apoptosis. Perturbations in the normal functions of mitochondria will inevitably disturb cell functio...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,评审


    authors: Krieger C,Duchen MR

    更新日期:2002-07-05 00:00:00

  • The role of atrial natriuretic peptide in the diuretic effect of Ca2+ entry blockers.

    abstract::The effect of three calcium entry blockers--verapamil, nifedipine and felodipine--on diuresis, natriuresis, the renin-aldosterone axis, and atrial natriuretic peptide (ANP) levels was studied in 30 previously untreated patients with mild to moderate essential hypertension. All three blockers produced significant antih...

    journal_title:European journal of pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Shamiss A,Peleg E,Rosenthal T,Ezra D

    更新日期:1993-03-16 00:00:00

  • Kappa-opiates and urination: pharmacological evidence for an endogenous role of the kappa-opiate receptor in fluid and electrolyte balance.

    abstract::In prehydrated rats, the administration of kappa-opiate agonists such as bremazocine, ethylketocyclazocine or compound Upjohn-50,488 produced a dose-dependent increase in urine output and decreased the concentration of Na+ and K+ in the urine as compared to that of saline-treated rats. The diuretic effect of bremazoci...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Huidobro-Toro JP,Parada S

    更新日期:1984-12-15 00:00:00

  • The role of endothelium-derived hyperpolarizing factor and cyclooxygenase pathways in the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in chronic sarpogrelate treated rats.

    abstract::We have demonstrated that the antagonism of 5-HT2 receptors produces an enhancement of serotonergic sympathoinhibitory effect by 5-HT1D and 5-HT7 activation. The aim of this work was to determine mechanisms involved in the 5-hydroxytriptaminergic inhibitory action on the pressor responses elicited by sympathostimulati...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: García-Pedraza JÁ,García M,Martín ML,San Román L,Morán A

    更新日期:2014-05-15 00:00:00

  • Tremulous jaw movements induced by the acetylcholinesterase inhibitor tacrine: effects of antiparkinsonian drugs.

    abstract::Several experiments were conducted to study the effects of established or potential antiparkinsonian drugs on the tremulous jaw movements induced by the anticholinesterase tacrine (9-amino-1,2,3,4-tetrahydroaminoacridine hydrochloride). In the first group of four experiments, separate groups of animals that received 2...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Cousins MS,Carriero DL,Salamone JD

    更新日期:1997-03-19 00:00:00

  • Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor.

    abstract::The calmodulin inhibitor 1,3-dihydro-1-[1-((4-methyl-4H,6H-pyrrolo[1,2-a]-[4,1]benzoxazepin - 4-yl)methyl)-4-piperidinyl]-2H-benzimidazol-2-one maleate (CGS 9343B) caused a reversible block of voltage-activated Ca2+, Na+, and K+ currents in differentiated rat pheochromocytoma (PC12) cells. The drug also inhibited nico...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Neuhaus R,Reber BF

    更新日期:1992-06-05 00:00:00

  • Selective and complete blockade of acetylcholine-induced relaxation in rabbit aortic rings by N omega-nitro-L-arginine but not by glybenclamide.

    abstract::This study addressed the possibility that acetylcholine-induced relaxation in the rabbit aorta is mediated by dual mechanisms: one N omega-nitro-L-arginine (NLA)-sensitive, the other glybenclamide-sensitive. Acetylcholine, nitroglycerin and BRL38227 (lemakalim), an activator of glybenclamide-sensitive potassium channe...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Bellan JA,Longenecker LL,Kadowitz PJ,McNamara DB

    更新日期:1993-04-06 00:00:00

  • Regional cyclic GMP content in incubated tissue slices of rat brain.

    abstract::Incubated tissue slices from different regions of the rat brain contained cyclic guanosine 3',5'-monophosphate (cyclic GMP) in the following descending order of content: cerebellum greater than hypothalamus greater than striatum greater than thalamusmidbrain greater than brain stem greater that hippocampus greater tha...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Palmer GC,Duszynski CR

    更新日期:1975-06-01 00:00:00

  • Nanomolar concentrations of neuropeptides induce histamine release from peritoneal mast cells of a substrain of Wistar rats.

    abstract::Substance P causes histamine release from rat peritoneal mast cells probably through direct activation of a specific G protein at micromolar concentrations. We found that peritoneal mast cells of a substrain of Wistar rats (Std:Wistar) responds to nanomolar concentrations of substance P by releasing histamine in a con...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Ogawa K,Nabe T,Yamamura H,Kohno S

    更新日期:1999-06-18 00:00:00

  • Parainfluenza virus type 1 reduces the affinity of agonists for muscarinic receptors in guinea-pig lung and heart.

    abstract::Membrane preparations of guinea-pig lung (containing multiple muscarinic receptor subtypes) and heart (containing M2 receptors only) were incubated with either neuraminidase, parainfluenza virus (which contains neuraminidase), or virus plus 2,3-dehydro-2-deoxy-N-acetylneuraminic acid, a neuraminidase inhibitor. None o...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Fryer AD,el-Fakahany EE,Jacoby DB

    更新日期:1990-05-31 00:00:00

  • Effects of imipramine or GABA(B) receptor ligands on the immobility, swimming and climbing in the forced swim test in rats following discontinuation of cocaine self-administration.

    abstract::We tested if discontinuation of cocaine self-administration can lead to the development of depressive-like symptoms in the forced swim test expressed as changes in immobility, swimming and climbing behaviors in rats. A "yoked" procedure in which rats were run simultaneously in groups of three, with two rats received t...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Frankowska M,Gołda A,Wydra K,Gruca P,Papp M,Filip M

    更新日期:2010-02-10 00:00:00

  • gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine.

    abstract::After incubation of rat cortical cell cultures with the human immunodeficiency virus type 1 (HIV-1) coat protein gp120 for 12 h, cells showed fragmentation of DNA at internucleosomal linkers, the characteristic feature of apoptosis. In a quantitative approach, it was determined that the percentage of DNA fragmentation...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Müller WE,Schröder HC,Ushijima H,Dapper J,Bormann J

    更新日期:1992-07-01 00:00:00

  • Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat.

    abstract::Direct instillation of a recombinant human form of MMP-12 (rhMMP-12) in mice airways elicited an early inflammatory response characterized by neutrophil influx, cytokine release and gelatinase activation followed by a delayed response, mainly characterized by macrophage recruitment. As this experimental model of lung ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Nénan S,Lagente V,Planquois JM,Hitier S,Berna P,Bertrand CP,Boichot E

    更新日期:2007-03-15 00:00:00