Quantitative autoradiography of beta-adrenoceptors in the cardiac vagus ganglia of the rat.

abstract：:The correlation between the Phosphoinositide 3-kinase (PI3K) axis and crucial mechanisms involved in the maintenance of the neoplastic nature of multiple myeloma (MM) has recently evolved a general agreement that PI3K inhibition-based therapies could construct an exciting perspective for the future treatment strategie...

journal_title：European journal of pharmacology

authors： Safaroghli-Azar A,Bashash D,Kazemi A,Pourbagheri-Sigaroodi A,Momeny M

更新日期：2019-01-05 00:00:00

abstract：:Diabetic cardiomyopathy (DCM) is one of the major cardiac complications in diabetic patients and a major reason for the death of diabetic patients. Obeticholic acid (OCA) is a semi-synthetic bile acid analogue. The objective of the present study was to investigate the possible cardio-protective effect of OCA against D...

journal_title：European journal of pharmacology

authors： Wu H,Liu G,He Y,Da J,Xie B

更新日期：2019-09-05 00:00:00

abstract：:The effects of a highly selective kappa antagonist, nor-binaltorphimine (nor-BNI), on the development of tolerance to morphine analgesia and physical dependence on morphine were examined. Pretreatment with nor-BNI (5 mg/kg s.c.) 2 h prior to injection of morphine or a selective kappa agonist, U-50,488H, significantly ...

journal_title：European journal of pharmacology

authors： Suzuki T,Narita M,Takahashi Y,Misawa M,Nagase H

更新日期：1992-03-17 00:00:00

abstract：:Clonidine and methysergide constrict the rabbit auricular artery by activating smooth muscle alpha-adrenoceptors. Clonidine inhibits and methysergide enhances responses to stimulation of the sympathetic nerves. Both drugs sensitise the artery to a variety of vasoconstrictor stimuli, although not to potassium chloride....

journal_title：European journal of pharmacology

authors： Fozard JR

更新日期：1976-03-01 00:00:00

abstract：:The effects of riluzole, an anticonvulsant and neuroprotective compound, on excitatory amino acid-evoked currents were studied in Xenopus laevis oocytes injected with mRNA from rat whole brain or cortex. Responses to kainic acid were blocked by riluzole (IC50 = 167 microM) as well as by the quinoxalinedione antagonist...

journal_title：European journal of pharmacology

authors： Debono MW,Le Guern J,Canton T,Doble A,Pradier L

更新日期：1993-04-28 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) have been shown great potential for cardiac regeneration. However the therapeutic efficiency has become a major obstacle due to the poor survival of transplanted MSCs in ischemic cardiac tissue. Previous studies reported that melatonin could protect many different types of cel...

journal_title：European journal of pharmacology

authors： Wang F,Zhou H,Du Z,Chen X,Zhu F,Wang Z,Zhang Y,Lin L,Qian M,Zhang X,Li X,Hao A

更新日期：2015-02-05 00:00:00

abstract：:Endothelial cells from rat brain microvessels, human aortic artery and human umbilical vein were examined, together with ex vivo rat brain capillaries and rat aortic ring sections, for the expression of opioid receptor-like OP-4 mRNA and protein. High levels of mRNA expression and an immunopositive reaction for the re...

journal_title：European journal of pharmacology

authors： Granata F,Potenza RL,Fiori A,Strom R,Caronti B,Molinari P,Donsante S,Citro G,Iacovelli L,De Blasi A,Ngomba RT,Palladini G,Passarelli F

更新日期：2003-12-15 00:00:00

abstract：:Acetylshikonin, a naphthoquinone isolated from the Chinese herb medicine, tzu ts'ao, was demonstrated to inhibit the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice. Liver glycogen content was increased in adrenalectomized mice pretreated with dexamethasone, but not with acetylshikonin...

journal_title：European journal of pharmacology

authors： Wang JP,Raung SL,Chang LC,Kuo SC

更新日期：1995-01-05 00:00:00

abstract：:Although the gastrointestinal tract is a rich source of melatonin and possesses numerous melatonin-binding sites, the role of melatonin in this tissue has not yet been fully elucidated. In this work we focused on the role of melatonin in the modulation of ion transport in rat distal colon. Whereas melatonin had no eff...

journal_title：European journal of pharmacology

authors： Mrnka L,Hock M,Rybová M,Pácha J

更新日期：2008-02-26 00:00:00

abstract：:This study investigated sex-related differences in rat papillary muscle force generation in response to altered extracellular [Ca2+] ([Ca2+](o), 0.2 to 5.0 mM) and to L-type Ca2+ channel modulators (nifedipine and Bay K8644). At all [Ca2+]o examined, contractile force was significantly greater in male than female papi...

journal_title：European journal of pharmacology

authors： Curl CL,Delbridge LM,Wendt IR

更新日期：2008-05-31 00:00:00

abstract：:Eating high-fat chow can modify the effects of drugs acting directly or indirectly on dopamine systems and repeated intermittent drug administration can markedly increase sensitivity (i.e., sensitization) to the behavioral effects of indirect-acting dopamine receptor agonists (e.g., methamphetamine). This study examin...

journal_title：European journal of pharmacology

authors： McGuire BA,Baladi MG,France CP

更新日期：2011-05-11 00:00:00

abstract：:The effect of ouabain (10(-3) M) on contractile responses of SHR (spontaneously hypertensive rat) and WKY (Wistar-Kyoto rat) aortas and mesenteric arteries was studied. Ouabain addition caused a rapid contraction of aortic strips with a steeper rate of rise and a larger maximal force development in strips from SHR tha...

journal_title：European journal of pharmacology

authors： Morita S,Iwasaki T,Nagai K,Miyata S,Kawai Y

更新日期：1988-07-14 00:00:00

abstract：:The aim of the study was to determine the influence of N-(ortho-carboxyanilinomethyl)-p-isopropoxyphenylsuccinimide [o-CAMIPPS], N-(meta-carboxyanilinomethyl)-p-isopropoxyphenylsuccinimide [m-CAMIPPS], and N-(para-carboxyanilinomethyl)-p-isopropoxyphenylsuccinimide [p-CAMIPPS] on the protective activity of four classi...

journal_title：European journal of pharmacology

authors： Luszczki JJ,Cioczek JD,Kocharov SL,Andres-Mach M,Kominek M,Zolkowska D

更新日期：2010-12-01 00:00:00

abstract：:The effect of systemic administration of the nonselective dopamine receptor agonist apomorphine on efflux of serotonin (5-hydroxytryptamine, 5-HT) in striatum and hippocampus of freely moving rats was examined using in vivo microdialysis. 5-HT efflux was increased by a moderate dose of apomorphine sufficient for a pos...

journal_title：European journal of pharmacology

authors： Mendlin A,Martín FJ,Jacobs BL

更新日期：1998-06-26 00:00:00

abstract：:Low levels of serotonin may reduce the density of the serotonin transporter (SERT) by either increasing trafficking or reducing synthesis; a "neuroadaptive response". To determine whether 3,4-methylenedioxymethamphetamine (MDMA)-induced reductions in SERT density could be related to such a mechanism, p-chlorophenylala...

journal_title：European journal of pharmacology

authors： Boot BP,Mechan AO,McCann UD,Ricaurte GA

更新日期：2002-10-25 00:00:00

abstract：:The histamine H3 agonist, (R)-alpha-methylhistamine (alpha-MeHA, 10(-10) to 10(-5) M), caused a concentration-dependent inhibition of the sympathetic contractile response to electrical field stimulation of guinea pig isolated atria, but alpha-MeHA did not alter the basal tension or the contraction induced by exogenous...

journal_title：European journal of pharmacology

authors： Luo XX,Tan YH,Sheng BH

更新日期：1991-11-12 00:00:00

abstract：:Excitotoxicity and imbalance of sodium and calcium homeostasis trigger pathophysiologic processes in cerebral ischemia which can accelerate neuronal death. Neuroprotective role of cannabidiol (CBD), one of the main non-psychoactive phytocannabinoids of the cannabis plant, has attracted attention of many researchers in...

journal_title：European journal of pharmacology

authors： Khaksar S,Bigdeli MR

更新日期：2017-01-05 00:00:00

abstract：:Interleukin-6 (IL-6) is a key proinflammatory cytokine which plays a central role in the pathogenesis of periodontal disease. Host modulatory agents targeting at inhibiting IL-6, therefore, appear to be beneficial in slowing the progression of periodontal disease and potentially reducing destructive aspects of the hos...

journal_title：European journal of pharmacology

authors： Choi EY,Jin JY,Choi JI,Choi IS,Kim SJ

更新日期：2014-04-15 00:00:00

abstract：:There is experimental evidence indicating that chronic moderate ethanol consumption delays the age-dependent increase in blood pressure. Since the brain natriuretic peptide (BNP) is a potent hypotensive hormone, the effect of chronic ethanol treatment on the heart BNP system was investigated, using spontaneously hyper...

journal_title：European journal of pharmacology

authors： Guillaume P,Jankowski M,Gutkowska J,Gianoulakis C

更新日期：1996-11-28 00:00:00

abstract：:A synthetic heptapeptide corresponding to the C-terminal heptapeptide of caerulein but characterized by a nor-leucyl residue replacing the methyonyl residue of caerulein, when given by i.v. infusion (2 mug/kg/h), inhibited by 70-80% pentagastrin (4 mug/kg/h)-stimulated gastric secretion... ...

journal_title：European journal of pharmacology

authors： Agosti A,Missale G,Bertaccini G

更新日期：1976-07-01 00:00:00

abstract：:Food intake is regulated by various factors such as neuropeptide Y. Neuropeptide Y potently induces an increase in food intake, and simultaneously stimulates arginine-vasopressin (AVP) secretion in the brain. Recently, we reported that V(1A) vasopressin receptor-deficient (V(1A)R(-/-)) mice exhibited altered daily foo...

journal_title：European journal of pharmacology

authors： Aoyagi T,Kusakawa S,Sanbe A,Hiroyama M,Fujiwara Y,Yamauchi J,Tanoue A

更新日期：2009-11-10 00:00:00

abstract：:Increased expressions of cyclooxygenase-2 (COX-2) and its downstream metabolite, prostaglandin E2 (PGE2), are well documented events in the development of colorectal cancer. Interestingly, PGE2 itself can induce the expression of COX-2 thereby creating the potential for positive feedback. Although evidence for such a ...

journal_title：European journal of pharmacology

authors： Yoshida K,Fujino H,Otake S,Seira N,Regan JW,Murayama T

更新日期：2013-10-15 00:00:00

abstract：:The breakdown of the relaxation-inducing second messengers cAMP and cGMP is mediated by phosphodiesterases. Inhibitors of functionally present phosphodiesterases can be expected to induce relaxation by increasing the basic amount of cAMP and/or cGMP. In the cat gastric fundus, vinpocetine, which has some selectivity f...

journal_title：European journal of pharmacology

authors： Barbier AJ,Lefebvre RA

更新日期：1995-03-24 00:00:00

abstract：:The calcium currents (ICa) of isolated smooth muscle cells (urinary bladder of the guinea-pig) were analyzed at 35 degrees C and 3.6 mM [Ca]0. The whole cells were voltage-clamped with a single patch electrode which was filled with 150 mM CsCl in order to block potassium outward currents. Tiapamil reduced ICa at conce...

journal_title：European journal of pharmacology

authors： Klöckner U,Isenberg G

更新日期：1986-08-15 00:00:00

abstract：:Sex and stress hormones coordinate experience and behaviour with physiological regulations. In the brain the sex hormones act to promote the repertoire of affiliative and reproductive behaviours. Stress hormones target in particular brain circuits underlying emotional arousal and cognition. To exert these actions the ...

journal_title：European journal of pharmacology

authors： de Kloet ER

更新日期：2010-01-10 00:00:00

abstract：:Effects of histamine receptor ligands on the glibenclamide-sensitive K+ currents induced by K+ channel openers, cromakalim and Y-26763, were examined in follicle-enclosed Xenopus oocytes. Histamine H1 receptor antagonists, promethazine, dimethindene and chlorpheniramine all decreased cromakalim-induced K+ currents wit...

journal_title：European journal of pharmacology

authors： Sakuta H

更新日期：1994-01-01 00:00:00

abstract：:The pharmacological activity of N-methyl-actinodaphnine, isolated from Illigera luzonensis, was determined by functional and binding experiments with peripheral tissues. In a functional study, N-methyl-actinodaphnine was a simple competitive antagonist of contractions elicited by phenylephrine (pA2 = 7.11) in rat thor...

journal_title：European journal of pharmacology

authors： Guh JH,Ko FN,Yu SM,Wu YC,Teng CM

更新日期：1995-06-06 00:00:00

abstract：:Sargaquinoic acid (designated previously as MC14) was isolated from a marine brown alga Sargassum macrocarpum, and has been found to possess a novel nerve growth factor (NGF)-dependent neurite outgrowth promoting activity in PC12D cells. In this study, we explored the neuroprotective effects of MC14 in terms of its su...

journal_title：European journal of pharmacology

authors： Tsang CK,Kamei Y

更新日期：2004-03-19 00:00:00

abstract：:In the present study, the development of tolerance to the motor impairing effects of gamma-hydroxybutyric acid (GHBA) and ethanol was compared (Experiment 1). Rats were required to perform a motor coordination task daily shortly after ethanol (3.5 g/kg) and GHBA (1.0 g/kg) administration for 9 consecutive days. Tolera...

journal_title：European journal of pharmacology

authors： Colombo G,Agabio R,Lobina C,Reali R,Fadda F,Gessa GL

更新日期：1995-02-06 00:00:00

abstract：:Pretreatment with the catecholamine precursor L-DOPA but not the narcotic antagonist naloxone suppressed the tremorigenic effect of oxotremorine in mice. However, when animals were pretreated with both L-DOPA and several different doses of naloxone, there was a dose-related potentiation of the antitremor effect of L-D...

journal_title：European journal of pharmacology

authors： Quock RM,Lucas TS

更新日期：1983-11-25 00:00:00