Characterization of beta-adrenoceptor subtypes in rabbit mononuclear leukocytes.

abstract：:The involvement of dopamine D-1 and D-2 receptor mechanisms was investigated in the forced swimming test with rats. d,1-Sulpiride, a D-2 receptor antagonist, reported to reduce desipramine-induced anti-immobility, did not alter the brain levels of desipramine. In addition, the anti-immobility effect of desipramine was...

journal_title：European journal of pharmacology

authors： Borsini F,Lecci A,Mancinelli A,D'Aranno V,Meli A

更新日期：1988-04-13 00:00:00

abstract：:Nitric oxide (NO) is continuously produced in the lung and can be measured in exhaled gas of different species. To investigate a possible neuro-humoral regulation of pulmonary NO production in vivo we injected veratrine, an activator of Na(+) channels known to activate the sympathoadrenal system, in anaesthetized, mec...

journal_title：European journal of pharmacology

authors： Adding LC,Agvald P,Artlich A,Gustafsson LE

更新日期：2001-01-12 00:00:00

abstract：:Recently, stable gastric pentadecapeptide BPC 157 reversed the high MDA- and NO-tissue values to the healthy levels. Thereby, BPC 157 therapy cured rats with bile duct ligation (BDL) (sacrifice at 2, 4, 6, 8 week). BPC 157-medication (10 μg/kg, 10 ng/kg) was continuously in drinking water (0.16 μg/ml, 0.16 ng/ml, 12 m...

journal_title：European journal of pharmacology

authors： Sever AZ,Sever M,Vidovic T,Lojo N,Kolenc D,Vuletic LB,Drmic D,Kokot A,Zoricic I,Coric M,Vlainic J,Poljak L,Seiwerth S,Sikiric P

更新日期：2019-03-15 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) has been identified as a potent and robust metabolic regulator. Administration of recombinant FGF21 protein to rodents and rhesus monkeys exerts strong anti-diabetic effects. Previous studies have demonstrated that FGF21 inhibits glucose output in the rat H4IIE hepatoma cell line. W...

journal_title：European journal of pharmacology

authors： Kong LJ,Feng W,Wright M,Chen Y,Dallas-yang Q,Zhou YP,Berger JP

更新日期：2013-02-28 00:00:00

abstract：:The effects of 26 anesthetic agents were studied on the rhythmical discharge activity of a single isolated neuron (crayfish stretch receptor). Many of these agents produced concentration-dependent biphasic responses (excitation and depression), and some also induced altered discharge patterns (burst activity). The dom...

journal_title：European journal of pharmacology

authors： MacIver MB,Roth SH

更新日期：1987-07-02 00:00:00

abstract：:The effect of dl-p-chloroamphetamine, fluoxetine and probenecid on the efflux of endogenous 5-hydroxytryptamine (5HT) and 5-hydroxyindoleacetic acid (5HIAA) into superfusates of the spinal cord of anesthetized rats was examined. Mean basal efflux of 5HT and 5HIAA was 0.27 and 15.56 ng/ml superfusate, respectively. The...

journal_title：European journal of pharmacology

authors： Hammond DL,Tyce GM,Yaksh TL

更新日期：1983-03-04 00:00:00

abstract：:Oxidative stress is associated with exacerbation of renal injuries in hypertension. In clinical studies benidipine hydrochloride (benidipine), a dihydropyridine calcium channel blocker with antioxidant activity, reduced oxidative stress. However, the mechanism of suppression of oxidative stress remains to be fully cha...

journal_title：European journal of pharmacology

authors： Matsubara M,Akizuki O,Ikeda J,Saeki K,Yao K,Sasaki K

更新日期：2008-02-02 00:00:00

abstract：:The locations of the vascular resistance sites which regulate vascular tone in the hepatic arterial and portal venous vasculatures of the rat liver were identified using a new, in vitro, dual-perfused liver preparation. Twelve livers of male Wistar rats were perfused via the hepatic artery and portal vein at fixed flo...

journal_title：European journal of pharmacology

authors： Yang W,Benjamin IS,Alexander B

更新日期：1999-01-01 00:00:00

abstract：:The inhibitory effects of the new bradykinin antagonist HOE 140 (D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg) on depressor responses to exogenous bradykinin were investigated in conscious rats and compared with those of the bradykinin antagonist B4146 (D-Arg-Hyp-Pro-Gly-Thi-Ser-D-Pro-Thi-Arg). HOE 140 showed a 250-700...

journal_title：European journal of pharmacology

authors： Bao G,Qadri F,Stauss B,Stauss H,Gohlke P,Unger T

更新日期：1991-07-23 00:00:00

abstract：:We used male Wistar rats to determine the effects of lipopolysaccharide (LPS) on gastric secretion. After pylorus ligation, 24-h fasted rats received i.p. injections of different doses of LPS dissolved in sterile saline. The amounts of gastric acid and pepsin secreted were determined 2, 4 or 8 h after injection. Small...

journal_title：European journal of pharmacology

authors： Uehara A,Okumura T,Okamura K,Takasugi Y,Namiki M

更新日期：1990-05-31 00:00:00

abstract：:The effect of KC 2450 (racemic 3,5-cis-3-methylamino-2,3,4,5-tetrahydro-1-benzoxepine-5-ol hydrochloride) on lower esophageal sphincter pressure in pentobarbital-anesthetized dogs was determined and compared to the effect of metoclopramide. The ED20 value (i.e. the dose that increased lower esophageal sphincter pressu...

journal_title：European journal of pharmacology

authors： Fowler PJ,Nelson AH,Price WJ,Sarau HM,Grous M,Lombardi DM,Barone FC,Ormsbee HS 3rd

更新日期：1987-10-13 00:00:00

abstract：:The effects of acute treatment with sibutramine on the peripheral sympathetic neurotransmission in vas deferens of young rats were still not evaluated. Therefore, we carried out this study in order to verify the effects of acute sibutramine treatment on the neuronal- and exogenous agonist-induced contractions of the y...

journal_title：European journal of pharmacology

authors： de Souza BP,da Silva ED Jr,Jurkiewicz A,Jurkiewicz NH

更新日期：2014-09-05 00:00:00

abstract：:Impairment of nitric oxide (NO) - cyclic GMP signaling pathway is likely to contribute to human begnin prostate hyperplasia (BPH). In the present study we have used a model of chronic NO synthesis inhibition to evaluate the functional alterations of prostate smooth muscle (PSM) machinery, and involvement of Rho-kinase...

journal_title：European journal of pharmacology

authors： Calmasini FB,Leiria LO,Alves Junior MJ,Báu FR,Alexandre EC,Silva FH,Mónica FZ,Antunes E

更新日期：2015-07-05 00:00:00

abstract：:The present work describes the mechanisms involved in the vasorelaxant effect of the diterpene ent-kaur-16-en-19-oic acid (kaurenoic acid). Kaurenoic acid (10, 50 and 100 microM) concentration-dependently inhibited phenylephrine and KCl-induced contraction in either endothelium-intact or -denuded rat aortic rings. Kau...

journal_title：European journal of pharmacology

authors： Tirapelli CR,Ambrosio SR,da Costa FB,Coutinho ST,de Oliveira DC,de Oliveira AM

更新日期：2004-05-25 00:00:00

abstract：:We have reported that neutrophil infiltration into gastric mucosa is closely related to gastric mucosal lesion development in rats with water immersion restraint stress. In this study, we examined the effect of teprenone, which is known to prevent gastric mucosal injury through stimulation of gastric mucus synthesis a...

journal_title：European journal of pharmacology

authors： Nishida K,Ohta Y,Ishiguro I

更新日期：1998-07-31 00:00:00

abstract：:In vitro effects of d,l-methadone and morphine on [3H]serotonin (3H-5-HT) uptake in rat periaqueductal gray (PAG) slices were investigated. Only methadone had a significant inhibitory effect on 3H-5-HT uptake which was significantly enhanced by naloxone. The systemic administration of methadone did not affect 3H-5-HT ...

journal_title：European journal of pharmacology

authors： Donzanti BA,Warwick RO

更新日期：1979-10-26 00:00:00

abstract：:The role of nitric oxide and cyclo-oxygenase products in the platelet-activating factor (PAF)-induced hyporesponsiveness to noradrenaline was investigated in pithed rats. Infusion of PAF (30 ng/kg/min) for 60 min reduced the mean arterial blood pressure and impaired the pressor responses to noradrenaline (10 ng/kg, 10...

journal_title：European journal of pharmacology

authors： Shiga T,Yoshikawa D

更新日期：1995-08-25 00:00:00

abstract：:This study was undertaken to define some of the cellular mechanisms of action of serotonin on cerebral vascular muscle. Application of serotonin to cat basilar artery resulted in a dose dependent depolarization and contraction beginning at 10(-8) M. The correlation coefficient relating the degree of force development ...

journal_title：European journal of pharmacology

authors： Harder DR,Waters A

更新日期：1983-09-16 00:00:00

abstract：:Neuropeptides represent by far the most common signalling molecules in the central nervous system. They are involved in a wide range of physiological functions and can act as neurotransmitters, neuromodulators or hormones in the central nervous system and in the periphery. Accumulating evidence during the past 40 year...

journal_title：European journal of pharmacology

authors： Ogren SO,Kuteeva E,Elvander-Tottie E,Hökfelt T

更新日期：2010-01-10 00:00:00

abstract：:4,6,6-Trimethylcaprolactam antagonised GABAA receptor-mediated contractile responses in guinea-pig isolated ileum, displacing the GABA dose-response curve to the right in a non-parallel manner, and causing a depression of the maximum response. Pentobarbitone not only potentiated the GABAA receptor-mediated contraction...

journal_title：European journal of pharmacology

authors： Kerr DI,Ong J,Prager RH,Ward DA

更新日期：1986-05-13 00:00:00

abstract：:The introduction of new iron chelating drugs may ultimately improve iron-chelation therapy for patients with iron overload diseases such as thalassaemia and other disorders. In this paper, the in vivo effects of baicalin and quercetin on iron overload induced liver injury were studied on mice. It was found that when i...

journal_title：European journal of pharmacology

authors： Zhang Y,Li H,Zhao Y,Gao Z

更新日期：2006-03-27 00:00:00

abstract：:There is controversy concerning the inhibitory effect of arginine-vasopressin (AVP) on human platelet adenylate cyclase activity, which putatively involves Gi as the G-protein. To clarify this point, the effects of AVP on human platelet membranes were studied by measuring the activities of the high-affinity GTPase, as...

journal_title：European journal of pharmacology

authors： Vittet D,Mathieu MN,Cantau B,Chevillard C

更新日期：1988-06-10 00:00:00

abstract：:Rat pheochromocytoma PC12W cell membranes have previously been shown to exclusively contain the AT2 receptor subtype. The present study extended these binding data and explored the functional expression of these binding sites. Our binding competition studies show a potency series of Ang II = Ang III greater than saral...

journal_title：European journal of pharmacology

authors： Leung KH,Roscoe WA,Smith RD,Timmermans PB,Chiu AT

更新日期：1992-09-01 00:00:00

abstract：:Vascular hypertrophy occurs during chronic hypertension and contributes to the elevation of peripheral vascular resistance in hypertension. In this study, we examined whether acute pressure overloading of the vascular wall produces activation of mitogen-activated protein (MAP) kinases, enzymes believed to be involved ...

journal_title：European journal of pharmacology

authors： Kubo T,Hosokawa H,Kambe T,Fukumori R

更新日期：2000-03-17 00:00:00

abstract：:Effects of chelerythrine and bisindolylmaleimide I on action potential duration and on voltage-activated K(+) and Ca(2+) currents in rat ventricular myocytes were studied using perforated patch-clamp technique. The action potentials were markedly prolonged after application of 20 microM chelerythrine or 100 nM bisindo...

journal_title：European journal of pharmacology

authors： Voutilainen-Myllylä S,Tavi P,Weckström M

更新日期：2003-04-11 00:00:00

abstract：:Lithium, commonly used to treat bipolar disorder, potentiates the ability of the muscarinic agonist pilocarpine to induce seizures in rodents. As this potentiation by lithium is reversed by the administration of myo-inositol, the potentiation may be mediated by inhibition of inositol monophosphatase (IMPase), a known ...

journal_title：European journal of pharmacology

authors： Singh N,Serres F,Toker L,Sade Y,Blackburn V,Batra AS,Saiardi A,Agam G,Belmaker RH,Sharp T,Vasudevan SR,Churchill GC

更新日期：2020-09-15 00:00:00

abstract：:Levodopa is the standard-of-care for Parkinson's disease, but continued loss of dopamine neurons with disease progression decreases its bioconversion to dopamine, leading to increased side effects and decreased efficacy. In theory, dopamine agonists could equal levodopa, but no approved oral "dopamine agonist" matches...

journal_title：European journal of pharmacology

authors： Mailman RB,Yang Y,Huang X

更新日期：2021-02-05 00:00:00

abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) destroys dopamine-containing nigrostriatal neurons and increases the apparent Bmax of both D1 and D2 binding sites in the striatum. However, the changes of Bmax occur at different intervals after the lesion. Up-regulation of D2 sites becomes evident about 3 weeks aft...

journal_title：European journal of pharmacology

authors： Weihmuller FB,Bruno JP,Neff NH,Hadjiconstantinou M

更新日期：1990-05-16 00:00:00

abstract：:The role of dopamine transmission on striatal acetylcholine release was investigated by using brain microdialysis. Blockade of dopamine D2 receptors with (-)-sulpiride or haloperidol increased acetylcholine release to a maximum of 80% (after 50 and 0.5 mg/kg, respectively). This effect was prevented by blockade of dop...

journal_title：European journal of pharmacology

authors： Imperato A,Obinu MC,Dazzi L,Gessa GL

更新日期：1994-01-14 00:00:00

abstract：:The present study aims to investigate whether azithromycin reverses P-glycoprotein-dependent anticancer drug resistance in vitro and modifies the hepatobiliary excretion of doxorubicin, a substrate for P-glycoprotein in vivo. Azithromycin increased dose-dependently the intracellular accumulation of doxorubicin in adri...

journal_title：European journal of pharmacology

authors： Asakura E,Nakayama H,Sugie M,Zhao YL,Nadai M,Kitaichi K,Shimizu A,Miyoshi M,Takagi K,Takagi K,Hasegawa T

更新日期：2004-01-26 00:00:00