Effect of methadone and morphine on serotonin uptake in rat periaqueductal gray slices.

abstract：:Adenosine added to isolated electrically driven preparations of human ventricular heart muscle antagonized the positive inotropic effect of isoprenaline (mean EC50 19 mumol 1(-1), n = 9). Similar effects were observed with the adenosine receptor agonist (-)-N6-phenylisopropyladenosine (mean EC50 0.5 mumol 1(-1), n = 7...

journal_title：European journal of pharmacology

authors： Böhm M,Meyer W,Mügge A,Schmitz W,Scholz H

更新日期：1985-10-22 00:00:00

abstract：:The effects of Ro 15-4513, FG 7142 and beta-CCM on the activity of the mesocortical dopaminergic system were examined by measuring the changes in the content of the principal dopamine (DA) metabolite, dihydroxyphenylacetic acid (DOPAC) in the prefrontal cortex of the rat. Ro 15-4513 increased the DOPAC content in the ...

journal_title：European journal of pharmacology

authors： Giorgi O,Corda MG,Biggio G

更新日期：1988-10-26 00:00:00

abstract：:We have previously shown that particular phenolic antidiarrheic ingredients, including 2-methoxy-4-methylphenol (2M4MP) and 2-methoxy-4-ethyphenol (2M4EP), but not 2-methoxyphenol (2MP), significantly inhibit cellular maturation and differentiation of the bone-resorbing osteoclasts with concomitant protection of the b...

journal_title：European journal of pharmacology

authors： Matsushima N,Nakamichi N,Kambe Y,Takano K,Moriguchi N,Yoneda Y

更新日期：2007-07-12 00:00:00

abstract：:We isolated a novel peptide, calcitonin receptor-stimulating peptide-1 (CRSP-1), from porcine brain and found that the administration of this peptide into rats induced a transient decrease in plasma calcium concentration. Therefore, we investigated the effects of CRSP-1 on osteoclastogenesis. Osteoclast-like cells wer...

journal_title：European journal of pharmacology

authors： Notoya M,Arai R,Katafuchi T,Minamino N,Hagiwara H

更新日期：2007-04-10 00:00:00

abstract：:Recombinant P2X2 receptor was observed by atomic force microscope in the aqueous phase. The P2X2 receptor was expressed in an insect cell line, and recombinant proteins were prepared under native conditions. The membrane fractions were extracted, and histidine-tagged receptor protein was purified from the fractions by...

journal_title：European journal of pharmacology

authors： Nakazawa K,Yamakoshi Y,Tsuchiya T,Ohno Y

更新日期：2005-08-22 00:00:00

abstract：:The cyclooxygenase (COX) pathway and prostanoids may critically contribute to the early allergic airway response. In the rat lung, serotonin (5-HT) is a major mediator of antigen-induced contractions. The aim of this study was therefore to examine the relative role of the COX pathway and serotonin for antigen-induced ...

journal_title：European journal of pharmacology

authors： Larsson-Callerfelt AK,Dahlén SE,Kühl AR,Lex D,Uhlig S,Martin C

更新日期：2013-01-15 00:00:00

abstract：:In order to identify new atypical antipsychotic drugs which are more selective for the human dopamine D4 receptor than for the human dopamine D2 (long) receptor, we tested enantiomer pairs of dopamine agonists and dopamine antagonists on the expressed proteins of these cloned receptors. The (+)-aporphines ((+)-N-propy...

journal_title：European journal of pharmacology

authors： Seeman P,Van Tol HH

更新日期：1993-03-16 00:00:00

abstract：:The release of [3H]5-hydroxytryptamine ([3H]5-HT) evoked by 15 mM KCl in superfused rat cerebellum synaptosomes was inhibited by 5-HT (pEC30 = 8.73). Methiothepin antagonized 5-HT (pA2 = 9.28); ketanserin, methysergide, cinanserin and spiperone were ineffective. The receptors involved were activated (pEC30 = 8.90) by ...

journal_title：European journal of pharmacology

authors： Bonanno G,Maura G,Raiteri M

更新日期：1986-07-31 00:00:00

abstract：:The effect of morphine on the capsaicin-induced cough reflex was studied in mu 1-opioid receptor-deficient CXBK mice. There was no significant difference between the morphine-induced antitussive effect in CXBK mice and C57BL/6 mice, a progenitor strain. Furthermore, the antitussive effects of morphine in both the CXBK...

journal_title：European journal of pharmacology

authors： Kamei J,Iwamoto Y,Suzuki T,Misawa M,Nagase H,Kasuya Y

更新日期：1993-08-10 00:00:00

abstract：:Dihydropyridine Ca(2+) channel antagonists (DHPs) block Ca(V)1.2 L-type Ca(2+) channels (LTCCs) by stabilizing their voltage-dependent inactivation (VDI); however, it is still not clear how DHPs allosterically interact with the kinetically distinct (fast and slow) VDI. Thus, we analyzed the effect of a prototypical DH...

journal_title：European journal of pharmacology

authors： Sheng X,Nakada T,Kobayashi M,Kashihara T,Shibazaki T,Horiuchi-Hirose M,Gomi S,Hirose M,Aoyama T,Yamada M

更新日期：2012-06-15 00:00:00

abstract：:Major depression is a prevalent and debilitating disorder and a substantial proportion of patients fail to reach remission following standard antidepressant pharmacological treatment. Limited efficacy with currently available antidepressant drugs highlights the need to develop more effective medications for treatment-...

journal_title：European journal of pharmacology

authors： Caldarone BJ,Zachariou V,King SL

更新日期：2015-04-15 00:00:00

abstract：:The characteristics of beta-adrenoceptors on frog and chick erythrocytes have been compared to those present on rat erythrocyte, lung and cerebral cortical membranes. The receptors have been examined using the specific ligand [3H]dihydroalprenolol ([3H]DHA) with conventional filtration techniques. The equilibrium diss...

journal_title：European journal of pharmacology

authors： Dickinson KE,Nahorski SR

更新日期：1981-08-27 00:00:00

abstract：:We have previously proposed that pro-inflammatory cytokines and nitric oxide (NO) contributed to reversible myocardial depression in patients with sepsis and congestive heart failure. Sepsis and heart failure are also associated with refractoriness to beta-adrenoceptor agonists. Therefore, the chronotropic effects of ...

journal_title：European journal of pharmacology

authors： Oddis CV,Finkel MS

更新日期：1997-02-12 00:00:00

abstract：:Activation of P2X7 receptors by endogenous ATP contributes to the development of inflammatory hyperalgesia. Given the clinical importance of mechanical hyperalgesia in inflammatory states, we hypothesized that the activation of the P2X7 receptor by endogenous ATP contributes to carrageenan-induced mechanical hyperalge...

journal_title：European journal of pharmacology

authors： Teixeira JM,Oliveira MC,Parada CA,Tambeli CH

更新日期：2010-10-10 00:00:00

abstract：:In adult male rats, injection of TRH into a lateral ventricle of the brain 5 min prior to pentobarbital (PB) administration caused a significant dose-related inhibition of prolactin (PRL) release, in doses ranging from 500 to 5 ng. Among 8 TRH analogues devoid of thyrotropin-releasing activity, 6 were found to signifi...

journal_title：European journal of pharmacology

authors： Taché Y,Ruisseau PD,Ducharme JR,Collu R

更新日期：1977-10-15 00:00:00

abstract：:Transient ischemia was produced for 15 min by occlusion of the middle cerebral artery in halothane-anesthetized rats, and changes in the extracellular concentrations of neurotransmitter monoamines and amino acids were examined in the striatum. The occlusion produced marked increases in the extracellular concentrations...

journal_title：European journal of pharmacology

authors： Hamami G,Adachi N,Liu K,Arai T

更新日期：2004-01-26 00:00:00

abstract：:Active sensitization of guinea-pigs resulted in an increase in responsiveness and sensitivity of tracheal and lung parenchymal strips to CaCl2 (in K+-depolarised tissue), KCl, acetylcholine and histamine. Indomethacin (5 microM) preferentially enhanced the response of tracheal strips from normal animals to histamine a...

journal_title：European journal of pharmacology

authors： Cortijo J,Ortiz JL,Sanz C,Sarría B,Pascual R,Perpiñá M,Esplugues J,Morcillo EJ

更新日期：1989-03-29 00:00:00

abstract：:We studied the effects of the tyrosine kinase inhibitors genistein and tyrphostin and the tyrosine phosphatase inhibitors sodium orthovanadate and phenylarsine oxide on endotoxin-mediated induction of nitric oxide (NO) synthase in rat aorta and its effects on vascular contractility. Genistein (i.p. 10 mg/kg) inhibited...

journal_title：European journal of pharmacology

authors： Duarte J,Ocete MA,Pérez-Vizcaino F,Zarzuelo A,Tamargo J

更新日期：1997-10-29 00:00:00

abstract：:Effluents from perfused acetylcholine-relaxed endothelium segments of rabbit aorta (or canin femoral artery) contained endothelium-derived relaxing factors (EDRF) which dilated the endothelium-free segments of rabbit femoral artery (or side branches of canine femoral artery). The half-life of EDRF was 24 +/- 3 s for t...

journal_title：European journal of pharmacology

authors： Förstermann U,Trogisch G,Busse R

更新日期：1984-11-27 00:00:00

abstract：:Using recombinant cell lines showing Ah receptor-controlled expression of a luciferase reporter gene, the interaction of di-ortho-substitute polychlorinated biphenyls (PCBs) with Ah receptor agonists was studied. In the recombinant Hepa1c1c7 mouse hepatoma (H1L1.1c7) cells strong antagonistic interaction of 2,2',5,5'-...

journal_title：European journal of pharmacology

authors： Aarts JM,Denison MS,Cox MA,Schalk MA,Garrison PM,Tullis K,de Haan LH,Brouwer A

更新日期：1995-12-07 00:00:00

abstract：:Neuropeptides represent by far the most common signalling molecules in the central nervous system. They are involved in a wide range of physiological functions and can act as neurotransmitters, neuromodulators or hormones in the central nervous system and in the periphery. Accumulating evidence during the past 40 year...

journal_title：European journal of pharmacology

authors： Ogren SO,Kuteeva E,Elvander-Tottie E,Hökfelt T

更新日期：2010-01-10 00:00:00

abstract：:Increased glycolysis under hypoxic stress is a fundamentally important feature of non-small cell lung cancer (NSCLC) cells, but molecular mechanisms of hypoxia on glycolysis remain elusive. Herein, we aimed to explore whether lncRNAs and miRNAs are involved in the glycolytic reprogramming under hypoxic conditions. The...

journal_title：European journal of pharmacology

authors： Shi J,Wang H,Feng W,Huang S,An J,Qiu Y,Wu K

更新日期：2019-11-05 00:00:00

abstract：:Adrenomedullin administered peripherally in the rabbit (at doses of 1.25, 2.5 and 5 microg/kg ) caused a dose-dependent conjunctival hyperemia accompanied by an increase of inflammatory cell number and prostaglandin E(2) concentration in the aqueous humor, and of uveal vascular response and myeloperoxidase activity. T...

journal_title：European journal of pharmacology

authors： Clementi G,Floriddia ML,Prato A,Marino A,Drago F

更新日期：2000-07-21 00:00:00

abstract：:The amyloid precursor protein (APP) has been mainly studied in its role in the production of amyloid β peptides (Aβ), because Aβ deposition is a hallmark of Alzheimer's disease. Although several studies suggest APP has physiological functions, it is still controversial. We previously reported that APP increased glial ...

journal_title：European journal of pharmacology

authors： Kwak YD,Marutle A,Dantuma E,Merchant S,Bushnev S,Sugaya K

更新日期：2011-01-10 00:00:00

abstract：:Parkinson's disease is a neuropathological disorder involving the degeneration of dopamine neurons in the substantia nigra, with the resultant loss of their terminals in the striatum. This dopamine loss causes most of the motor disturbances associated with the disease. One animal model of Parkinson's disease involves ...

journal_title：European journal of pharmacology

authors： Boules M,Warrington L,Fauq A,McCormick D,Richelson E

更新日期：2001-10-05 00:00:00

abstract：:Rats were trained to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline in a two-lever, food-motivated operant task. Once trained, the rats were tested with the ED50 of apomorphine (0.02 mg/kg) or saline before and 1-22 days after a ten-day regimen of daily 2.0 mg/kg admi...

journal_title：European journal of pharmacology

authors： Schechter MD

更新日期：1981-09-24 00:00:00

abstract：:Here, we present a neuroendocrine concept to review the circularly interacting energy homeostasis system between brain and body. Body-brain interaction is circular because the brain immediately integrates an input to an output, and because part of this response may be that the brain modulates the sensitivity of this p...

journal_title：European journal of pharmacology

authors： Kreier F,Kalsbeek A,Ruiter M,Yilmaz A,Romijn JA,Sauerwein HP,Fliers E,Buijs RM

更新日期：2003-11-07 00:00:00

abstract：:A close relationship between the renin-angiotensin system and the pathophysiology of diabetic retinopathy has been suggested, several angiotensin II type 1 receptor (angiotensin AT1 receptor) antagonists being effective in animal models. Therefore, we examined the efficacy of an angiotensin AT1 receptor antagonist, ol...

journal_title：European journal of pharmacology

authors： Nakamura H,Inoue T,Arakawa N,Shimizu Y,Yoshigae Y,Fujimori I,Shimakawa E,Toyoshi T,Yokoyama T

更新日期：2005-04-11 00:00:00

abstract：:The effect of adrenaline on the electrically evoked noradrenaline overflow in the portal vein of adrenal demedullated freely moving rats was studied. Adrenaline (100 ng/min) was infused for 2 h into the portal vein. After a 1-h interval when plasma adrenaline had returned to pre-infusion undetectable levels, the porta...

journal_title：European journal of pharmacology

authors： Coppes RP,Smit J,Khali NN,Brouwer F,Zaagsma J

更新日期：1993-10-26 00:00:00

abstract：:Opioid antagonists, naloxone and naltrexone have long been used in clinical practice and research. In addition to their low selectivity, they easily pass through the blood-brain barrier. Quaternization of the amine group in these molecules, (e.g. methylnaltrexone) results in negligible CNS penetration. In addition, zw...

journal_title：European journal of pharmacology

authors： Zádor F,Király K,Váradi A,Balogh M,Fehér Á,Kocsis D,Erdei AI,Lackó E,Zádori ZS,Hosztafi S,Noszál B,Riba P,Benyhe S,Fürst S,Al-Khrasani M

更新日期：2017-08-15 00:00:00