Beneficial effect of pharmacological mobilization of bone marrow in experimental cerebral ischemia.

abstract：:3,5-Dihydroxyphenylglycine (DHPG), (S)-3-hydroxyphenylglycine and (S)-4-carboxy-3-hydroxyphenylglycine (S-4C3HPG) stimulated phosphoinositide hydrolysis in neonatal rat cortical slices, but with lower maximal effect, in comparison with 2S,1'S,2'S-2-(2'-carboxycyclopropyl)glycine (L-CCG I) or (1S,3R)-1-aminocyclo-penta...

journal_title：European journal of pharmacology

authors： Schaffhauser H,de Barry J,Muller H,Heitz MP,Gombos G,Mutel V

更新日期：1997-09-10 00:00:00

abstract：:We investigated the involvement of p160ROCK (a Rho-associated coiled coil-forming protein kinase), one of Rho kinases on superoxide anion production (O(2)(-) production), aggregation and adhesion of human polymorphonuclear leukocytes under physiological condition, using a selective p160ROCK inhibitor, (+)-(R)-trans-4-...

journal_title：European journal of pharmacology

authors： Kawaguchi A,Ohmori M,Harada K,Tsuruoka S,Sugimoto K,Fujimura A

更新日期：2000-09-08 00:00:00

abstract：:The present study was carried out to clarify the role of nonselective cation channels as a Ca2+ entry pathway in the contraction and the increase in [Ca2+]i induced by endothelin- in endothelium-denuded rat thoracic aorta rings, and their suppression by nitric oxide (NO). In Ca2+-free medium, the endothelin-1-induced ...

journal_title：European journal of pharmacology

authors： Zhang XF,Komuro T,Miwa S,Minowa T,Iwamuro Y,Okamoto Y,Ninomiya H,Sawamura T,Masaki T

更新日期：1998-07-10 00:00:00

abstract：:The effects of GABA and diazepam on the spontaneous and potassium-evoked release of 3H-5-HT from rat hippocampal synaptosomes, preloaded by incubation with 3H-5-HT, have been investigated. Both GABA and diazepam independently increased the spontaneous release of 5-HT whereas they blocked the calcium-dependent, potassi...

journal_title：European journal of pharmacology

authors： Balfour DJ

更新日期：1980-11-07 00:00:00

abstract：:DNA methylation is considered as a potential cause of aberrations in regulation of gene expression during carcinogenesis. Therefore, changes in DNA methylation patterns may be targets for chemoprevention. In the present study, we investigated effects of all-trans retinoic acid (ATRA), vitamin D(3), and resveratrol alo...

journal_title：European journal of pharmacology

authors： Stefanska B,Rudnicka K,Bednarek A,Fabianowska-Majewska K

更新日期：2010-07-25 00:00:00

abstract：:The role of pertussis toxin-sensitive G proteins on the alpha 2-adrenoceptor and mu-opioid receptor-mediated inhibition of the efferent function of capsaicin-sensitive neurones was investigated in guinea-pig atria pretreated with guanethidine. In the presence of atropine, CGP 20712A (2-hydroxy-5-(2-[hydroxy-3-(4-[(1-m...

journal_title：European journal of pharmacology

authors： Amerini S,Rubino A,Mantelli L,Filippi S,Ledda F

更新日期：1992-06-17 00:00:00

abstract：:The effects of a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) on serum leptin levels were investigated in mice. 5-HTP dose dependently increased serum leptin levels in mice. Pretreatment of the peripheral aromatic amino acid decarboxylase inhibitor carbidopa suppressed 5-HTP-induced hyperleptinemia. These re...

journal_title：European journal of pharmacology

authors： Yamada J,Sugimoto Y,Ujikawa M

更新日期：1999-10-21 00:00:00

abstract：:The effect of local administration of big endothelin-1 (1-38, big ET-1) has been investigated on blood flow in the skin of anaesthetised rats, measured by 133Xe clearance. The local effects of big ET-1 and big endothelin-3 (1-41, big ET-3) have also been determined on microvessel diameter by intravital microscopy of t...

journal_title：European journal of pharmacology

authors： Lawrence E,Brain SD

更新日期：1993-03-23 00:00:00

abstract：:The aim of the present study was to compare, in chloral-hydrate anaesthetized rats, the alpha(2)-adrenergic properties of the selective 5-HT(1A) receptor agonist, alnespirone (S-20499), with those of buspirone, a 5-HT(1A) receptor agonist exhibiting potent alpha(2)-adrenoceptor antagonist properties via its principal ...

journal_title：European journal of pharmacology

authors： Astier B,Lambás Señas L,Soulière F,Schmitt P,Urbain N,Rentero N,Bert L,Denoroy L,Renaud B,Lesourd M,Muñoz C,Chouvet G

更新日期：2003-01-10 00:00:00

abstract：:Interleukin-8 is assumed to play a central role in the pathogenesis of psoriasis. Since an increased expression of the interleukin-8 receptor has been observed both in polymorphonuclear leukocytes and in affected psoriatic epidermis, we were interested in whether the interleukin-8 receptor could be a molecular target ...

journal_title：European journal of pharmacology

authors： Kemény L,Kenderessy AS,Olasz E,Michel G,Ruzicka T,Farkas B,Dobozy A

更新日期：1994-06-13 00:00:00

abstract：:A previous report showed that transforming growth factor-beta1 (TGF-beta1) can induce heme oxygenase-1 (HO-1) expression, attenuate cellular injury, and maintain tissue homeostasis. In this study, we investigated the involvement of phosphoinositide-3-OH-kinase (PI3K)/Akt and the nuclear factor-kappaB (NF-kappaB) signa...

journal_title：European journal of pharmacology

authors： Lin CC,Chiang LL,Lin CH,Shih CH,Liao YT,Hsu MJ,Chen BC

更新日期：2007-04-10 00:00:00

abstract：:Large doses of dexamphetamine, methylamphetamine and MPTP failed to induce the formation of 6-hydroxydopamine (6-OHDA) in rat striatum. The potent dopamine (DA) releasing actions of these drugs and of the MPTP metabolite MPP+ were shown by intracerebral dialysis of DA in conscious rats but 6-OHDA was not detectable in...

journal_title：European journal of pharmacology

authors： Rollema H,De Vries JB,Westerink BH,Van Putten FM,Horn AS

更新日期：1986-12-02 00:00:00

abstract：:Gaboxadol (THIP; 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) is an agonist at GABA(A) receptors. THIP concentrations (0.01-50 mM) were applied rapidly to Sf9 cells expressing the human alpha(1)beta(2)gamma(2S) GABA(A) receptors. The EC(50) values for the peak current in THIP alone or THIP plus 1 microM diazepam we...

journal_title：European journal of pharmacology

authors： Smith M,Lindquist CE,Birnir B

更新日期：2003-09-30 00:00:00

abstract：:The spontaneous firing rate of the noradrenergic neurons of the locus coeruleus and of the serotonergic neurons of the dorsal raphe was recorded with extracellular microelectrodes in chloral hydrate-anesthetized rats. A quantitative comparison of the effect of five tricyclic antidepressants, of tranylcypromine and of ...

journal_title：European journal of pharmacology

authors： Scuvée-Moreau JJ,Dresse AE

更新日期：1979-08-01 00:00:00

abstract：:The aim of the present study was to investigate the contribution of extracellular signal regulated kinase-1/2 (ERK1/2) to pulmonary artery contraction in response to 4-aminopyridione (4-AP), an inhibitor of a voltage-gated K(+) channels that regulate pulmonary vascular tone. Pulmonary artery rings 1-1.5 mm in diameter...

journal_title：European journal of pharmacology

authors： Han W,Tang X,Wu H,Liu Y,Zhu D

更新日期：2007-08-13 00:00:00

abstract：:The identification of adenylyl cyclase isoenzymes in mammalian host cells is important for the interpretation of data obtained from cell lines heterologously expressing G-protein coupled receptors. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to amplify adenylyl cyclase cDNAs from Chinese hamster ...

journal_title：European journal of pharmacology

authors： Varga EV,Stropova D,Rubenzik M,Wang M,Landsman RS,Roeske WR,Yamamura HI

更新日期：1998-05-08 00:00:00

abstract：:Endothelial dysfunction is associated with a reduced bioavailability of nitric oxide (NO). In this study, the effects of 17β-estradiol supplement on endothelial function were examined in ovariectomized (OVX) rats following long-term inhibition of NO synthases with L-NAME. Female Sprague Dawley rats were ovariectomized...

journal_title：European journal of pharmacology

authors： Shi Y,Leung SWS

更新日期：2020-09-05 00:00:00

abstract：:The kinetics of [3H]dexetimide dissociation from muscarine receptors in bovine cardiac left ventricular and tracheal smooth muscle membranes were studied in the absence and presence of three muscarine antagonists. It was found that [3H]dexetimide dissociation from cardiac muscarine receptors was monophasic and very fa...

journal_title：European journal of pharmacology

authors： Roffel AF,Elzinga CR,Meurs H,Zaagsma J

更新日期：1989-03-07 00:00:00

abstract：:The models currently used to assess antinociceptive efficacy in animals are far from ideal. Those procedures that detect both opioid agonists and mixed agonist-antagonists fail to differentiate between them unless the noxious stimulus is adjusted. Furthermore, changes in the sensitivity of the test often result in pos...

journal_title：European journal of pharmacology

authors： Pizziketti RJ,Pressman NS,Geller EB,Cowan A,Adler MW

更新日期：1985-12-10 00:00:00

abstract：:Prolactin blood level and apomorphine-induced yawning were studied in rats treated with the substituted benzamide amisulpride in association with bromocriptine or carmoxirole; two dopamine D(2) receptor agonists with high or low propensity to cross the brain-blood barrier, respectively. Administration of amisulpride p...

journal_title：European journal of pharmacology

authors： Marchese G,Ruiu S,Casti P,Bartholini F,Saba P,Gessa GL,Pani L

更新日期：2002-06-28 00:00:00

abstract：:27-O-Caffeoyl myricerone (50-235) is a nonpeptide endothelin receptor antagonist which is highly selective for the endothelin ETA receptor subtype. In order to determine which functional groups in 50-235 are essential for its activity, we examined the potencies of 50-235 and its derivatives to inhibit [125I]endothelin...

journal_title：European journal of pharmacology

authors： Mihara S,Sakurai K,Nakamura M,Konoike T,Fujimoto M

更新日期：1993-10-15 00:00:00

abstract：UNLABELLED:This study analyzed the role of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) in gender differences in the renal vascular reactivity of rats. Renal responses to vasoconstrictors and vasodilators were studied in isolated kidneys from male and female rats under basal conditions, after...

journal_title：European journal of pharmacology

authors： Wangensteen R,Moreno JM,Sainz J,Rodríguez-Gómez I,Chamorro V,Luna Jde D,Osuna A,Vargas F

更新日期：2004-02-23 00:00:00

abstract：:The myocardial effects of g-strophanthin and the partial beta 1-adrenoceptor agonist xamoterol were compared to the effects of isoprenaline in the isolated spontaneously beating rabbit heart. Xamoterol and g-strophanthin both produced a distinct maximum increase in contractility as shown by the increase in isotonic co...

journal_title：European journal of pharmacology

authors： Vigholt Sørensen E,Nielsen-Kudsk F

更新日期：1986-06-24 00:00:00

abstract：:Carbocyclic thromboxane A2 (CTA2) constricted rabbit basilar and saphenous arteries. The contractions of the basilar artery, but not those of the saphenous artery, were potently inhibited by the calcium antagonist nimodipine. Selective inhibition of thromboxane-induced vasoconstriction of cerebral vessels may contribu...

journal_title：European journal of pharmacology

authors： Towart R,Perzborn E

更新日期：1981-01-16 00:00:00

abstract：:The Na(+)/Ca(2+) exchanger (NCX) is involved in myocardial ischemia-reperfusion injuries. We examined the effects of 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400), a potent and selective inhibitor of NCX, on myocardial ischemia-reperfusion injury models. In canine cardiac sarcolemmal vesicles an...

journal_title：European journal of pharmacology

authors： Takahashi K,Takahashi T,Suzuki T,Onishi M,Tanaka Y,Hamano-Takahashi A,Ota T,Kameo K,Matsuda T,Baba A

更新日期：2003-01-01 00:00:00

abstract：:Neuroinflammation contributes to the pathogenesis of neurological disorders including stroke, head trauma, multiple sclerosis, amyotrophic lateral sclerosis as well as age-associated neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Therefore, anti-inflammatory drugs could be used to slow the...

journal_title：European journal of pharmacology

authors： Madeira JM,Beloukhina N,Boudreau K,Boettcher TA,Gurley L,Walker DG,McNeil WS,Klegeris A

更新日期：2012-02-15 00:00:00

abstract：:The acute administration of MDMA has been shown to promote glycogenolysis and increase the extracellular concentration of glucose in the striatum. In the present study the role of serotonergic and/or noradrenergic mechanisms in the MDMA-induced increase in extracellular glucose and glycogenolysis was assessed. The rel...

journal_title：European journal of pharmacology

authors： Pachmerhiwala R,Bhide N,Straiko M,Gudelsky GA

更新日期：2010-10-10 00:00:00

abstract：:Oxidative stress and inflammation play key roles in the pathogenesis of Multiple sclerosis (MS). Different drugs have been used in the clinical practice, however, there is not a completely effective treatment. Due to its potential therapeutic action, medical ozone represents a promising approach for neurodegenerative ...

journal_title：European journal of pharmacology

authors： Delgado-Roche L,Riera-Romo M,Mesta F,Hernández-Matos Y,Barrios JM,Martínez-Sánchez G,Al-Dalaien SM

更新日期：2017-09-15 00:00:00

abstract：:The effects of the unilateral application of d-amphetamine, benztropine, haloperidol and thioproperazine to one substantia nigra on the release of 3H-dopamine (3H-DA) in the two caudate nuclei were examined in halothane-anesthetized cats. For this purpose animals were implanted with push-pull cannulae and 3H-DA was es...

journal_title：European journal of pharmacology

authors： Nieoullon A,Cheramy A,Leviel V,Glowinski J

更新日期：1979-01-15 00:00:00

abstract：:Ischemia/reperfusion injury ends up in the cascade of excitotoxic stimulation of superoxide and nitric oxide formation leading to the generation of highly reactive products, including peroxinitrite and hydroxyl radical, which are capable of damaging lipids, proteins and DNA. Several polyphenolic compounds scavenge the...

journal_title：European journal of pharmacology

authors： ArunaDevi R,Lata S,Bhadoria BK,Ramteke VD,Kumar S,Sankar P,Kumar D,Tandan SK

更新日期：2010-01-25 00:00:00