Big endothelin-1 and big endothelin-3 are constrictor agents in the microvasculature: evidence for the local phosphoramidon-sensitive conversion of big endothelin-1.

abstract：:Inhaled corticosteroids (ICS) are recommended treatments for all degrees of asthma severity and in combination with bronchodilators are indicated for COPD patients with a history of frequent exacerbations. However, the long-term side effects of glucocorticoids (GCs) may include increased risk of respiratory infections...

journal_title：European journal of pharmacology

authors： Marcellini A,Swieboda D,Guedán A,Farrow SN,Casolari P,Contoli M,Johnston SL,Papi A,Solari R

更新日期：2021-02-15 00:00:00

abstract：:Induction of anaphylactic shock in mice by i.v. antigen challenge (bovine serum albumin, 100 micrograms) or i.v. treatment with the mast cell degranulator compound 48/80 resulted in 80 and 90% mortality rate, respectively. Inhibition of nitric oxide (NO) synthesis from L-arginine by co-injection of the L-arginine anal...

journal_title：European journal of pharmacology

authors： Amir S,English AM

更新日期：1991-10-02 00:00:00

abstract：:Dynorphin (1-100 nM) dose dependently inhibited both spontaneous and electrically evoked endogenous dopamine (DA) release from slices of the nucleus accumbens of untreated rats. When this inhibitory effect was compared, it was significantly reduced in rats pretreated (for 9 days) with methamphetamine (6 mg/kg per day ...

journal_title：European journal of pharmacology

authors： Yokoo H,Yamada S,Yoshida M,Tanaka M,Nishi S

更新日期：1992-11-03 00:00:00

abstract：:Calcium channel blockers appear to reduce the cardiac toxicity of cocaine and some stimulant-induced behaviors. The present experiment was designed to test whether the internal state induced by cocaine is altered by the calcium antagonist nimodipine. Substitution tests with the calcium agonist BAY K 8644 were also con...

journal_title：European journal of pharmacology

authors： Callahan PM,Cunningham KA

更新日期：1990-09-04 00:00:00

abstract：:In this study the effect of purified rat anti-mouse IL-5 monoclonal antibody on aeroallergen-induced infiltration of eosinophils in the bronchoalveolar lavage fluid of guinea pigs was studied. The i.p. injection of anti-IL-5 antibody 4 h after aeroallergen challenge inhibited eosinophil infiltration in a dose-dependen...

journal_title：European journal of pharmacology

authors： Chand N,Harrison JE,Rooney S,Pillar J,Jakubicki R,Nolan K,Diamantis W,Sofia RD

更新日期：1992-01-28 00:00:00

abstract：:Molecular identification of two new transient receptor potential (TRP) channels, TRPM8 and TRPA1, has prompted an intense interest in their functional roles. We report that an acute exposure to the TRPM8/TRPA1 agonist icilin (0.01-100 microM), but not TRPV1 agonist capsaicin (10 microM), causes an atypical dose-relate...

journal_title：European journal of pharmacology

authors： Rawls SM,Gomez T,Ding Z,Raffa RB

更新日期：2007-12-01 00:00:00

abstract：:Captivity-induced stereotypies in bank voles (Clethrionomys glareolus) were inhibited at the age of 1, 2, 4, 6, 8 and 10 months by 0.2 mg/kg haloperidol s.c., while 35 mg/kg naloxone s.c. only inhibited them at the age of 4-6 months. Other activities were not significantly inhibited. The change in the naloxone effect ...

journal_title：European journal of pharmacology

authors： Kennes D,Odberg FO,Bouquet Y,De Rycke PH

更新日期：1988-08-09 00:00:00

abstract：:CysLT1 receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT2 receptors in this condition have not been determined. The purpose of this study is to develop an experimental model of CysLT2 receptor-mediated LTC4-induced lung air-trapping in guinea pigs and use this mod...

journal_title：European journal of pharmacology

authors： Sekioka T,Kadode M,Yonetomi Y,Kamiya A,Fujita M,Nabe T,Kawabata K

更新日期：2017-01-05 00:00:00

abstract：:The role of the alpha 1-adrenoceptor subtypes, and their possible change with maturation, in alpha 1-adrenoceptor-induced pressor responses in the rat has not been established. Thus, the effects of the alpha 1D-, alpha 1A/1D- and alpha 1B/1D-adrenoceptor antagonists, BMY 7378 (8-(2-(4-(2-methoxyphenyl)-1-piperazinyl)e...

journal_title：European journal of pharmacology

authors： Ibarra M,Terrón JA,López-Guerrero JJ,Villalobos-Molina R

更新日期：1997-03-19 00:00:00

abstract：:Severe depletion of 5-hydroxytryptamine (5-HT) by para-chlorophenylalanine (pCPA, 150 mg/kg per day x3) did not alter the hypophagic effect of d-fenfluramine (1-3 mg/kg i.p.) 1 h after food presentation in 24-h food-deprived rats, and moderately and comparably increased the hypophagic effects of its metabolite, d-norf...

journal_title：European journal of pharmacology

authors： Gibson EL,Kennedy AJ,Curzon G

更新日期：1993-09-21 00:00:00

abstract：:We have investigated the mode of cardiovascular action of the stimulant methylhexaneamine (MHA) in terms of direct or indirect adrenergic actions in anaesthetised rats. Male and female rats were anaesthetised with pentobarbitone and pressor (changes in diastolic blood pressure) and cardioaccelerator responses to MHA w...

journal_title：European journal of pharmacology

authors： Alsufyani HA,Docherty JR

更新日期：2019-01-15 00:00:00

abstract：:Endogenous hydrogen sulfide is produced by cystathionine-γ-lyase and cystathionine-β-synthase in a variety of tissues and has recently been implicated in the regulation of cardiac functions. Acceleration of the heart rate in response to catecholamines is impaired in patients with cirrhosis. The present study was aimed...

journal_title：European journal of pharmacology

authors： Babaei-Karamshahlou M,Hooshmand B,Hajizadeh S,Mani AR

更新日期：2012-12-05 00:00:00

abstract：:In cross-chopped slices from rat thalamus and in the presence of 10 mM LiCl, noradrenaline stimulated the accumulation of [3H]inositol phosphates with [3H]inositol monophosphates ([3H]IP1) being the major product detected (86 +/- 2% of total [3H]inositol phosphates). Noradrenaline-induced [3H]IP1 accumulation was conc...

journal_title：European journal of pharmacology

authors： Trejo F,De la Vega MT,Arias-Montaño JA

更新日期：1996-12-27 00:00:00

abstract：:The effect of colchicine on jejunal adenylate cyclase activity, prostaglandin E2 (PGE2) and cAMP contents, the enzyme and mediators involved in intestinal fluid secretion was tested in rats. Four h after the intraperitoneal injection of colchicine (0.5 mg/100 g body wt.) mucosal PGE2 content, adenylate cyclase activit...

journal_title：European journal of pharmacology

authors： Rachmilewitz D,Karmeli F

更新日期：1980-10-17 00:00:00

abstract：:Interactions between cannabinoid CB(1) and GABA receptors and ligands were investigated in the myenteric plexus-longitudinal muscle of the guinea pig ileum. Electrically evoked contractions of the myenteric plexus-longitudinal muscle were inhibited by the cannabinoid receptor agonist CP55,940 ((-)-cis-3-[2-Hydroxy-4-(...

journal_title：European journal of pharmacology

authors： Begg M,Molleman A,Parsons M

更新日期：2002-01-02 00:00:00

abstract：:Atherosclerosis is regarded as chronic inflammatory disease. The IL-6/STAT3 pathway plays an important role in inflammation. We previously described a small-molecule compound, Bazedoxifene, which target IL-6/STAT3 pathway and has been approved for clinical use for osteoporosis in postmenopausal women. The aim of this ...

journal_title：European journal of pharmacology

authors： Luo P,Wang Y,Zhao C,Guo J,Shi W,Ma H,Liu T,Yan D,Huo S,Wang M,Li C,Lin J,Li S,Lv J,Zhang C,Lin L

更新日期：2021-02-15 00:00:00

abstract：:Pretreatment of guinea pigs with 5 microgram/kg isoprenaline or 10 microgram/kg salbutamol s.c. thrice daily for 7 days reduced the responsiveness of lung slice and tracheal ring adenylate cyclase to isoprenaline, but not to prostaglandin E1. Pretreatment of guinea pigs with isoprenaline also reduced the sensitivity o...

journal_title：European journal of pharmacology

authors： Elfellah MS,Turnbull MJ

更新日期：1978-10-01 00:00:00

abstract：:Amphetamine increases extracellular dopamine and induces locomotor and stereotypical behaviors in rats. This study examined the effect of the dopamine D2/D3 receptor antagonist sulpiride (50 mg/kg s.c.) on the dopaminergic response to amphetamine (0.5, 2.0, or 8.0 mg/kg i.p.) in male Sprague-Dawley rats. Extracellular...

journal_title：European journal of pharmacology

authors： Jaworski JN,Gonzales RA,Randall PK

更新日期：2001-04-27 00:00:00

abstract：:GABAA receptors are pentameric chloride ion channels that are opened by GABA. We have screened a cell line derived from human glioblastoma, U3047MG, for expression of GABAA receptor subunit isoforms and formation of functional ion channels. We identified GABAA receptors subunit α2, α3, α5, β1, β2, β3, δ, γ3, π, and θ ...

journal_title：European journal of pharmacology

authors： Babateen O,Jin Z,Bhandage A,Korol SV,Westermark B,Forsberg Nilsson K,Uhrbom L,Smits A,Birnir B

更新日期：2015-02-05 00:00:00

abstract：:Pulmonary hypertension (PH) is a disease with a developmental origin characterized by obstructive vascular remodelling that is partially due to excessive pulmonary arterial smooth muscle cells (PASMCs) proliferation. Paeonol has important effects on vascular cell proliferation, migration, and inflammation, but researc...

journal_title：European journal of pharmacology

authors： Zhang L,Ma C,Gu R,Zhang M,Wang X,Yang L,Liu Y,Zhou Y,He S,Zhu D

更新日期：2018-09-05 00:00:00

abstract：:Anti-tumor activity of bakuchiol, an analogue of resveratrol, was investigated on human lung adenocarcinoma A549 cell line. MTT assay revealed that IC(50) of bakuchiol at 72h was 9.58+/-1.12 micromol/l, much lower than that of resveratrol (33.02+/-2.35 micromol/l). Bakuchiol but not resveratrol elevated intracellular ...

journal_title：European journal of pharmacology

authors： Chen Z,Jin K,Gao L,Lou G,Jin Y,Yu Y,Lou Y

更新日期：2010-09-25 00:00:00

abstract：:The involvement of the GABA(A)-benzodiazepine receptor complex in rat pup ultrasonic vocalisations was studied by testing benzodiazepine receptor ligands with varying intrinsic activity and selectivity for benzodiazepine subtype receptors. Ultrasonic vocalisations were recorded under two temperature conditions (37 deg...

journal_title：European journal of pharmacology

authors： Olivier B,Molewijk E,van Oorschot R,van der Heyden J,Ronken E,Mos J

更新日期：1998-10-02 00:00:00

abstract：:With age an increase in prostatic smooth muscle tone mediated by α1L-adrenoceptors contributes to the lower urinary tract symptoms associated with benign prostatic hyperplasia. Current treatments for benign prostatic hyperplasia include α1-adrenoceptor antagonists which inhibit smooth muscle contraction. However, musc...

journal_title：European journal of pharmacology

authors： White CW,Short JL,Ventura S

更新日期：2013-12-05 00:00:00

abstract：:The cardiovascular effects of atriopeptins (AP) I, II and III were compared in spontaneously beating or electrically stimulated guinea pig atria and in rabbit aortic strips precontracted by various agonists. Atriopeptins did not significantly affect sinus nodal rate or atrial contractility. AP II and III, although mor...

journal_title：European journal of pharmacology

authors： Bergey JL,Kotler D

更新日期：1985-04-02 00:00:00

abstract：:Activation of imidazoline receptors in the central nervous system has protective effect on several types of arrhythmias. We demonstrated that centrally administered rilmenidine, a selective imidazoline receptor agonist, prevented adrenaline-induced arrhythmias during halothane anaesthesia. However, detailed myocardial...

journal_title：European journal of pharmacology

authors： Yamanaka H,Hayashi Y,Iwasaki M,Kamibayashi T,Yamatodani A,Mashimo T

更新日期：2010-11-25 00:00:00

abstract：:Clonidine and methysergide constrict the rabbit auricular artery by activating smooth muscle alpha-adrenoceptors. Clonidine inhibits and methysergide enhances responses to stimulation of the sympathetic nerves. Both drugs sensitise the artery to a variety of vasoconstrictor stimuli, although not to potassium chloride....

journal_title：European journal of pharmacology

authors： Fozard JR

更新日期：1976-03-01 00:00:00

abstract：:The action of a novel 5-HT3 receptor antagonist, AS-5370, has been studied on two electrophysiological models for 5-HT3 receptors: whole-cell patch-clamp recordings from mouse neuroblastoma-rat glioma (NG108-15) cells and grease-gap recordings from rat isolated vagus nerve. The 5-hydroxytryptamine (5-HT)-induced fast ...

journal_title：European journal of pharmacology

authors： Newberry NR,Sprosen TS,Watkins CJ,Leslie RA,Grahame-Smith DG

更新日期：1992-08-14 00:00:00

abstract：:The specific binding of [3H]desipramine to various brain regions and peripheral tissues of the rat was of high affinity, rapid and reversible. It was inhibited with high affinity only by tricyclic antidepressants and noradrenaline uptake blockers. There was a highly significant correlation between the potencies of a s...

journal_title：European journal of pharmacology

authors： Raisman R,Sette M,Pimoule C,Briley M,Langer SZ

更新日期：1982-03-12 00:00:00

abstract：:Citrus flavonoids are acknowledged for numerous pharmacological activities, including the myorelaxant effect on various smooth muscles. However, there is no data on their effect on jejunum contractility. Therefore, the aim of the study at hand was to evaluate the impact of hesperetin and diosmetin along with their gly...

journal_title：European journal of pharmacology

authors： Mendel M,Chłopecka M,Dziekan N,Karlik W

更新日期：2016-11-15 00:00:00

abstract：:The adenosine-receptor modulation of noradrenaline release was compared in prostatic and epididymal portions of rat vas deferens. In both portions, tritium overflow elicited by electrical stimulation (100 pulses/8 Hz) was reduced by the adenosine A(1) receptor agonist, N(6)-cyclopentyladenosine, and enhanced by the no...

journal_title：European journal of pharmacology

authors： Queiroz G,Diniz C,Gonçalves J

更新日期：2002-07-12 00:00:00