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Effects of respiratory and metabolic alkalosis and acidosis on pipecuronium neuromuscular block.

Abstract：

:Acute respiratory and metabolic acidosis as well as metabolic alkalosis increased (by 11, 11, 21%) whereas respiratory alkalosis antagonized (by 10%) the partial steady state block produced by pipecuronium infusion on the anterior tibialis muscle of the cat. The duration of neuromuscular block following six successive doses of pipecuronium was prolonged 1.4-fold during long-lasting metabolic alkalosis while this parameter was shortened to half of that in control cats during acidosis. Pipecuronium block could be fully antagonized by neostigmine.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Biró K

doi

10.1016/0014-2999(88)90210-5

subject

Has Abstract

pub_date

1988-09-23 00:00:00

pages

329-33

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(88)90210-5

journal_volume

154

pub_type

杂志文章

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