当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Effect of chlorpropamide and phenformin on rat liver: the effect on plasma membrane-bound enzymes and cyclic AMP content of hepatocytes in vitro.

Effect of chlorpropamide and phenformin on rat liver: the effect on plasma membrane-bound enzymes and cyclic AMP content of hepatocytes in vitro.

Abstract：

:Chlorpropamide and phenformin inhibited (Na+ - K+)-ATPase and stimulated a high affinity cyclic AMP-phosphodiesterase of isolated liver plasma membrane when tested in vitro. In addition, the two drugs decreased the intracellular cyclic AMP content of isolated hepatocytes without being effective on plasma membrane-bound adenylate cyclase. The results suggest that the plasma membrane plays an important role in the mechanism of action of the two hypoglycemic drugs, but do not exclude the presence of intracellular targets.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Luly P,Baldini P,Cocco C,Incerpi S,Tria E

doi

10.1016/0014-2999(77)90251-5

subject

Has Abstract

pub_date

1977-11-15 00:00:00

pages

153-64

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(77)90251-5

journal_volume

46

pub_type

杂志文章

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