Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2'-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice.

abstract：:4,6,6-Trimethylcaprolactam antagonised GABAA receptor-mediated contractile responses in guinea-pig isolated ileum, displacing the GABA dose-response curve to the right in a non-parallel manner, and causing a depression of the maximum response. Pentobarbitone not only potentiated the GABAA receptor-mediated contraction...

journal_title：European journal of pharmacology

authors： Kerr DI,Ong J,Prager RH,Ward DA

更新日期：1986-05-13 00:00:00

abstract：:Preclinical and clinical findings indicate that a GABA(B) receptor agonist baclofen decreases cocaine use. The present study investigated the effects of the GABA(B) receptor antagonist (2S)-(+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911), the agonists baclofen and 3-aminopropyl(methyl)phoshinic acid (SKF 97541) a...

journal_title：European journal of pharmacology

authors： Filip M,Frankowska M,Przegaliński E

更新日期：2007-11-28 00:00:00

abstract：:There is now evidence from human studies to suggest that cardiac beta-adrenoceptor density and coupling to adenylate cyclase may be regulated in a subtype selective fashion. An animal model was used to investigate this further. Rats were infused for 6 days with the non-selective full agonist isoprenaline (n = 6) or th...

journal_title：European journal of pharmacology

authors： Arnold IR,Mistry R,Barnett DB

更新日期：1993-05-15 00:00:00

abstract：:In the rat substantia nigra Type II benzodiazepine recognition sites (measured as the portion of [3H]flunitrazepam binding which remain after the addition of 2 X 10(-7) M Cl 218872) represent 50% of the total benzodiazepine recognition sites. The density of Type II sites was increased by 35% following the degeneration...

journal_title：European journal of pharmacology

authors： Porceddu ML,Corda MG,Sanna E,Biggio G

更新日期：1985-06-07 00:00:00

abstract：:The alpha1-adrenoceptor subtypes of rat prostate were characterized in binding and functional experiments. In binding experiments, [3H]tamsulosin bound to a single class of binding sites with an affinity (pKD) of 10.79+/-0.04 and Bmax of 87+/-2 fmol mg(-1) protein. This binding was inhibited by prazosin, 2-(2,6-dimeth...

journal_title：European journal of pharmacology

authors： Hiraoka Y,Ohmura T,Oshita M,Watanabe Y,Morikawa K,Nagata O,Kato H,Taniguchi T,Muramatsu I

更新日期：1999-01-29 00:00:00

abstract：:Dopamine injected directly into the caudate--putamen, nucleus accumbens or tuberculum olfactorium of rat brain, following a nialamide pretreatment, caused dose-dependent hyperactivity. The hyperactivity was more intense after injections into the nucleus accumbens, but was limited by the development of stereotyped biti...

journal_title：European journal of pharmacology

authors： Costall B,Naylor RJ

更新日期：1976-11-01 00:00:00

abstract：:Animal studies have shown that endogenous estrogens such as 17β-estradiol (E2) can modulate lipid profiles in vivo, and this effect is generally thought to be mediated by the estrogen receptors (ERs). The present study sought to test a hypothesis that some of the endogenous estrogen metabolites that have very weak est...

journal_title：European journal of pharmacology

authors： Wang P,Zhu BT

更新日期：2017-04-05 00:00:00

abstract：:alpha 2-adrenoceptor-mediated contractions of the rabbit saphenous vein were previously found to be inhibited by wortmannin, a protein kinase inhibitor which blocks receptor-dependent phospholipase D activation. Since other studies have indicated that receptor-dependent phospholipase D activation required activity of ...

journal_title：European journal of pharmacology

authors： Jinsi A,Deth RC

更新日期：1995-04-13 00:00:00

abstract：:In epithelial tumors, the epidermal growth factor receptor (EGFR) controls key signaling pathways responsible for growth, proliferation, migration, and survival of tumor cells. The epidermal growth factor receptor variant III (EGFRvIII) is the most common EGFR mutation that occurs in up to 30% of high-grade gliomas es...

journal_title：European journal of pharmacology

authors： Chistiakov DA,Chekhonin IV,Chekhonin VP

更新日期：2017-09-05 00:00:00

abstract：:In many vascular smooth muscle cells, physiological and pharmacological agonists initiate oscillatory fluctuations in intracellular Ca(2+) to initiate and maintain vasoconstriction. These oscillations are supported by the underlying cellular ultrastructure, particularly the close apposition between the plasma membrane...

journal_title：European journal of pharmacology

authors： Dai JM,Syyong H,Navarro-Dorado J,Redondo S,Alonso M,van Breemen C,Tejerina T

更新日期：2010-03-10 00:00:00

abstract：:Acute leukemia is a malignant clonal hematopoietic stem cell disease. In the current study, we examined the effects of bryostatin 5 on acute monocytic leukemia cells in vitro and in vivo. We also explored the mechanisms and pathways underlying the increase in apoptosis induced by bryostatin 5. Bryostatin 5 inhibited t...

journal_title：European journal of pharmacology

authors： Wang Y,Zhang J,Wang Q,Zhang T,Yang Y,Yi Y,Gao G,Dong H,Zhu H,Li Y,Lin H,Tang H,Chen X

更新日期：2013-10-15 00:00:00

abstract：:The involvement of tachykinin NK1 receptors in the plasma protein extravasation (measured by the Evans blue leakage technique) produced by intravenous administration of capsaicin was investigated in the urinary bladder and trachea of anesthetized rats. Capsaicin-induced plasma extravasation was markedly inhibited by (...

journal_title：European journal of pharmacology

authors： Eglezos A,Giuliani S,Viti G,Maggi CA

更新日期：1991-12-17 00:00:00

abstract：:Cocaine dependence continues to be a worldwide public health concern. Although the majority of individuals reporting cocaine use do so via the intranasal route, relatively few laboratory experiments have examined the reinforcing effects of cocaine administered intranasally. The purpose of this experiment was to measur...

journal_title：European journal of pharmacology

authors： Stoops WW,Lile JA,Glaser PE,Hays LR,Rush CR

更新日期：2010-10-10 00:00:00

abstract：:Ouabain- and bumetanide-resistant potassium fluxes were measured in human erythrocytes incubated in a medium containing calcium and a calcium ionophore. Pharmacological concentrations of rat atrial natriuretic peptide stimulated these fluxes. Although human erythrocytes lack atrial natriuretic peptide receptors, our r...

journal_title：European journal of pharmacology

authors： Esparza N,Díez J

更新日期：1989-07-18 00:00:00

abstract：:It has been reported that the antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI) may result from the modulation of brain monoaminergic systems. However, the mechanisms of FDPI action are not fully understood. The aim of this study was to investigate the contribution of N-methyl-d-aspartate ...

journal_title：European journal of pharmacology

authors： Pesarico AP,Stangherlin EC,Rosa SG,Mantovani AC,Zeni G,Nogueira CW

更新日期：2016-07-05 00:00:00

abstract：:Venenum Bufonis, a traditional Chinese medicine, is widely used in the treatment of liver cancer in modern Chinese medical practices. In our search for anti-hepatoma constituents in Venenum Bufonis, bufotalin, bufalin, telocinobufagin and cinobufagin were obtained. Bufotalin was the most potent active compound among t...

journal_title：European journal of pharmacology

authors： Zhang DM,Liu JS,Tang MK,Yiu A,Cao HH,Jiang L,Chan JY,Tian HY,Fung KP,Ye WC

更新日期：2012-10-05 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gaseous molecule and is endogenously produced in the brain by cystathionine beta-synthase, 3-mercaptopyruvate-sulfurtransferase, cysteine aminotransferase and cystathionine γ-lyase. Physiologically, H2S acts as a neuromodulator and regulates synaptic activity of neurons and glia to promote ...

journal_title：European journal of pharmacology

authors： He JT,Li H,Yang L,Mao CY

更新日期：2019-04-15 00:00:00

abstract：:The aim of this study was to characterise the 5-HT receptor(s) mediating secretory responses of isolated human colonic mucosa to 5-HT. Sheets of muscle-stripped mucosa from proximal (ascending) and distal (sigmoid) human colon were set up in Ussing chambers for measurement of short-circuit current (Isc). Serosal appli...

journal_title：European journal of pharmacology

authors： Borman RA,Burleigh DE

更新日期：1996-08-15 00:00:00

abstract：:We employed an ex vivo [(3)H]rolipram binding experiment to elucidate the mechanism of emetic activity of phosphodiesterase 4 inhibitors. In Suncus murinus (an insectivore used for evaluation of emesis), emetic potential as well as ability to occupy the high-affinity rolipram binding site in brain membrane fraction in...

journal_title：European journal of pharmacology

authors： Hirose R,Manabe H,Nonaka H,Yanagawa K,Akuta K,Sato S,Ohshima E,Ichimura M

更新日期：2007-11-14 00:00:00

abstract：:Nerisopam, an anxiolytic and antipsychotic homophthalazine induces rapid, intense expression of Fos-like immunoreactivity in the rostral, dorsomedial and lateral parts of the striatum in the rat. Fos-positive cells also occurred in the globus pallidus, the olfactory tubercle and in the accumbens nucleus (in the cone a...

journal_title：European journal of pharmacology

authors： Palkovits M,Baffi JS,Berzsenyi P,Horváth EJ

更新日期：1997-07-16 00:00:00

abstract：:The cardiac plexus, which contains parasympathetic ganglia, plays an important role in regulating cardiac function. Histamine is known to excite intracardiac ganglion neurons, but the underlying mechanism is obscure. In the present study, therefore, the effect of histamine on rat intracardiac ganglion neurons was inve...

journal_title：European journal of pharmacology

authors： Sato A,Arichi S,Kojima F,Hayashi T,Ohba T,Cheung DL,Eto K,Narushima M,Murakoshi H,Maruo Y,Kadoya Y,Nabekura J,Ishibashi H

更新日期：2020-11-05 00:00:00

abstract：:This study investigated the effect of the platelet-activating factor (PAF) receptor antagonist, PCA 4248, on the rat pleurisy caused by PAF, serotonin, bradykinin, histamine or allergen. The pleurisy was assessed by measuring liquid extravasation and leucocyte infiltration. Oral pretreatment with PCA 4248 (2.5-20 mg/k...

journal_title：European journal of pharmacology

authors： Martins MA,Lima MC,Bozza PT,Faria Neto HC,Silva PM,Sunkel CE,Cordeiro RS

更新日期：1993-06-11 00:00:00

abstract：:In vitro effects of d,l-methadone and morphine on [3H]serotonin (3H-5-HT) uptake in rat periaqueductal gray (PAG) slices were investigated. Only methadone had a significant inhibitory effect on 3H-5-HT uptake which was significantly enhanced by naloxone. The systemic administration of methadone did not affect 3H-5-HT ...

journal_title：European journal of pharmacology

authors： Donzanti BA,Warwick RO

更新日期：1979-10-26 00:00:00

abstract：:The relationship between adipocytes and infiltrated macrophages in fat tissue is important for the pathogenesis of insulin resistance through the activation of cytokines. Peroxisome proliferator-activated receptors (PPARs) play a role in the regulation of cytokine secretion in these cells. We studied the effect of the...

journal_title：European journal of pharmacology

authors： Murakami K,Bujo H,Unoki H,Saito Y

更新日期：2007-04-30 00:00:00

abstract：:Recent studies in this laboratory have demonstrated the ability of acetylcholine receptor agonists to produce systemic arterial pressor responses through stimulation of spinal muscarinic receptors. In urethane-anesthetized rats a new surgical procedure was employed to permit microinjection of drugs into the cerebrospi...

journal_title：European journal of pharmacology

authors： Feldman DS,Buccafusco JJ

更新日期：1993-12-21 00:00:00

abstract：:The functional characteristics of purinoceptors in Chinese hamster ovary (CHO) cells were investigated using a microphysiometer which detects small metabolic changes to living cells in real-time as variations of pH in the extracellular microenvironment. Uridine 5'-triphosphate (UTP) increased the extracellular acidifi...

journal_title：European journal of pharmacology

authors： Okada Y,Taniguchi T,Akagi Y,Muramatsu I

更新日期：2002-11-22 00:00:00

abstract：:The effects of cytosolic ATP on Ca2+-dependent K+ (K(Ca)) channel activation in cultured bovine adrenal chromaffin cells were investigated by using single-channel recording patch-clamp techniques. Application of ATP to the intracellular surface of excised inside-out patches activated K(Ca) channels in a dose-dependent...

journal_title：European journal of pharmacology

authors： Chen C,Houchi H,Tamaki T,Nakaya Y

更新日期：1998-06-05 00:00:00

abstract：:We have demonstrated that activation of ATP-sensitive potassium (K(ATP)) channels can attenuate sympathetic hyperinnervation. Sildenafil, a phosphodiesterase-5 inhibitor, has been shown to provide a preconditioning-like cardioprotective effect via opening of K(ATP) channels. The aim of this study was to investigate wh...

journal_title：European journal of pharmacology

authors： Lee TM,Chen CC,Chung TH,Chang NC

更新日期：2012-09-05 00:00:00

abstract：:Prior studies demonstrated that guanabenz reduces systemic blood pressure by inhibiting central sympathetic outflow as well as by adrenergic neuron blockade. Potential mechanisms responsible for the reduction of efferent sympathetic activity were examined in the present series. Guanabenz failed to modify carotid sinus...

journal_title：European journal of pharmacology

authors： Baum T,Shropshire AT

更新日期：1976-05-01 00:00:00

abstract：:CysLT1 receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT2 receptors in this condition have not been determined. The purpose of this study is to develop an experimental model of CysLT2 receptor-mediated LTC4-induced lung air-trapping in guinea pigs and use this mod...

journal_title：European journal of pharmacology

authors： Sekioka T,Kadode M,Yonetomi Y,Kamiya A,Fujita M,Nabe T,Kawabata K

更新日期：2017-01-05 00:00:00