Histamine depolarizes rat intracardiac ganglion neurons through the activation of TRPC non-selective cation channels.

abstract：:Growing evidences suggest the presence of several similarities in the molecular mechanisms underlying the neurodegenerative diseases and metabolic abnormalities. Adults who develop Metabolic Syndrome (MS) are at a higher risk of developing Alzheimer's disease (AD). Pharmacological agents, like dipeptidyl peptidase-4 (...

journal_title：European journal of pharmacology

authors： Yossef RR,Al-Yamany MF,Saad MA,El-Sahar AE

更新日期：2020-12-15 00:00:00

abstract：:The role of prostaglandins in the secretion of inhibin and oestradiol-17 beta was examined in immature female rats treated with equine chorionic gonadotrophin. Administration of prostaglandin (PG) F2 alpha to animals whose serum and ovarian levels of inhibin and oestradiol-17 beta had been suppressed by indomethacin g...

journal_title：European journal of pharmacology

authors： Kogo H,Takasaki K,Takeo S,Watanabe G,Taya K,Sasamoto S

更新日期：1993-02-16 00:00:00

abstract：:The purpose of this study was to investigate possible efflux mechanisms involved in amphetamine derivative transport such as for 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyethylamphetamine (MDEA), para-methoxyamphetamine (p-MA), dexamphetamine and pseudoephedrine, especially across pH gradients that e...

journal_title：European journal of pharmacology

authors： Crowe A,Diep S

更新日期：2008-09-11 00:00:00

abstract：:An in vitro method was developed for the biochemical and autoradiographic demonstration of low muscarinic receptor densities in peripheral tissue. Histological criteria point clearly to the necessity for fixation to preserve tissue quality. [3H]l-Quinuclidinylbenzilate bound specifically to a homogeneous class of bind...

journal_title：European journal of pharmacology

authors： Van Megen YJ,Teunissen MJ,Klaassen AB,Rodrigues de Miranda JF

更新日期：1988-01-05 00:00:00

abstract：:We have recently proposed that retinoic acid receptor (NR1B) is a promising target of neuroprotective therapy for intracerebral hemorrhage, since pretreatment of mice with an NR1B1/NR1B2 agonist Am80 attenuated various pathological and neurological abnormalities associated with the disease. In the present study we fur...

journal_title：European journal of pharmacology

authors： Matsushita H,Hijioka M,Hisatsune A,Isohama Y,Shudo K,Katsuki H

更新日期：2012-05-15 00:00:00

abstract：:Methoctramine, a selective M2 alpha muscarinic receptor antagonist, was examined for its ability to inhibit carbachol-induced drinking in the rat. Intracerebroventricularly (i.c.v.) administered methoctramine was devoid of activity up to a dose of 100 nmol/rat, whereas higher doses were toxic under our experimental co...

journal_title：European journal of pharmacology

authors： Massi M,Polidori C,Melchiorre C

更新日期：1989-04-25 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) have been proposed as inhibitory non-adrenergic non-cholinergic (NANC) neurotransmitters in the rat gastric fundus. The smooth muscle relaxant actions of VIP and NO are medaited by cAMP and cGMP, respectively; therefore the effect of inhibitors of phosphodi...

journal_title：European journal of pharmacology

authors： Barbier AJ,Lefebvre RA

更新日期：1992-01-21 00:00:00

abstract：:We examined the effects of the administration of 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-pregna-1,4,9( 11)-triene-3,20-dione, monomethansulfonate (U74389F), a 21-aminosteroid and so-called lazaroid, that is characterized by an inhibitory activity against iron-dependent lipid peroxidation, on ischemi...

journal_title：European journal of pharmacology

authors： Paroni R,De Vecchi E,Lubatti L,Conti E,Beretta C,Rinaldi P,Kienle MG,Trazzi R

更新日期：1995-12-29 00:00:00

abstract：:The effect of furosemide on carbohydrate metabolism was studied in ob/ob mice. Intraperitoneal injection of a single dose of furosemide (200 mg/kg body weight) into fasted mice resulted in acute hyperglycaemia and two days after such a single dose, the mice showed fasting hyperglycaemia and glucose intolerance. Pancre...

journal_title：European journal of pharmacology

authors： Sandström PE,Sehlin J

更新日期：1988-03-15 00:00:00

abstract：:We have studied the ability of various uptake blockers to protect the dopamine neuronal carrier labeled with [3H]GBR 12783 (1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-(propenyl)-piperazine) against N-ethylmaleimide-induced alkylation, using membrane preparations obtained from rat striatum. Pure uptake inhibitors such ...

journal_title：European journal of pharmacology

authors： Héron C,Costentin J,Bonnet JJ

更新日期：1994-11-03 00:00:00

abstract：:A bicarbonate-dependent organic cation transporter, unique from rOCT1 and rOCT2, primarily mediates amantadine uptake into renal proximal tubules. We examined whether intracellular pH regulates bicarbonate-dependent amantadine transporter function in these tubules. NH(4)Cl treatment resulted in immediate intracellular...

journal_title：European journal of pharmacology

authors： Goralski KB,Bose R,Sitar DS

更新日期：2006-07-10 00:00:00

abstract：:The present study investigated the effect of acidosis (reduction in pH of the Krebs' solution from 7.4 to 6.9) on responses to vasoconstrictors and vasodilators, with a focus on purines, in the rat isolated perfused mesenteric arterial bed. alpha,beta-Methylene ATP (alpha,beta-meATP) (10 microM), a selective P2X recep...

journal_title：European journal of pharmacology

authors： Ralevic V

更新日期：2000-10-06 00:00:00

abstract：:The aim of this study was to characterise the 5-HT receptor(s) mediating secretory responses of isolated human colonic mucosa to 5-HT. Sheets of muscle-stripped mucosa from proximal (ascending) and distal (sigmoid) human colon were set up in Ussing chambers for measurement of short-circuit current (Isc). Serosal appli...

journal_title：European journal of pharmacology

authors： Borman RA,Burleigh DE

更新日期：1996-08-15 00:00:00

abstract：:Activating mutations in FMS-like tyrosine kinase 3 (FLT3) occur in 25% of acute lymphoid and 30% of acute myeloid leukaemia cases. Therefore, FLT3 is a potential therapeutic target for small molecule kinase inhibitors. In this study, protein-ligand interactions between FLT3 and kinase inhibitors (CEP701, PKC412, sunit...

journal_title：European journal of pharmacology

authors： Mashkani B,Tanipour MH,Saadatmandzadeh M,Ashman LK,Griffith R

更新日期：2016-04-05 00:00:00

abstract：:The ability of the kappa-opioid receptor agonist U69593 to attenuate the sensitization and cross-sensitization which develops to the conditioned rewarding effects of morphine and cocaine was examined using an unbiased place-preference conditioning procedure. The influence of U69593 treatment upon sensitization and cro...

journal_title：European journal of pharmacology

authors： Shippenberg TS,LeFevour A,Thompson AC

更新日期：1998-03-12 00:00:00

abstract：:Quantitative receptor autoradiography has been employed to determine the binding distribution of [3H]SR 95531 (2'-(3'-carboxy-2',3'-propyl)-3-amino-6-p-methoxyphenylpyrazinium bromide), a GABAA receptor antagonist, in the rat brain. The location showed good correspondence, in most areas, with the binding of [3H]GABA t...

journal_title：European journal of pharmacology

authors： Bristow DR,Martin IL

更新日期：1988-03-29 00:00:00

abstract：:Kynuramine increased heart rate and blood pressure in pithed rats. Heart rate responses were blocked by beta-adrenoceptor antagonists and reserpine pretreatment. Both of these treatments reduced the pressor responses to kynuramine. Remaining pressor activity was inhibited by phentolamine. The pressor responses to kynu...

journal_title：European journal of pharmacology

authors： Johnson TD,Clarke DE

更新日期：1983-02-18 00:00:00

abstract：:We tested the hypothesis that relaxation of the rat mesenteric artery in response to insulin is mediated by K(+) channels. Two concentrations of insulin (10 and 100 mU/ml) induced relaxation of the artery by 6+/-1%, 24+/-3% (mean+/-S.E.M.). Denudation of the endothelium or precontraction by KCl (30 mM), clotrimazole (...

journal_title：European journal of pharmacology

authors： Iida S,Taguchi H,Watanabe N,Kushiro T,Kanmatsuse K

更新日期：2001-01-05 00:00:00

abstract：:The pharmacological profile of YM358, 2,7-diethyl-5-[[2'-(1 H-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]tri azole potassium salt monohydrate, a novel non-peptide angiotensin AT1 receptor antagonist, was studied in vitro and in vivo. YM358 competed with [125I][Sar1, Ile8]angiotensin II for angiotensi...

journal_title：European journal of pharmacology

authors： Shibasaki M,Fujimori A,Takanashi M,Kusayama T,Tokioka T,Satoh Y,Okazaki T,Uchida W,Inagaki O,Yanagisawa I

更新日期：1997-09-24 00:00:00

abstract：:Previous studies have shown that sertindole (1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl ]-2 imidazolidinone), an atypical antipsychotic drug that is a potent 5-HT2A and dopamine D2 receptor antagonist, preferentially affects mesocorticolimbic rather than mesostriatal dopamine neurons. Usin...

journal_title：European journal of pharmacology

authors： Watanabe M,Hagino Y

更新日期：1999-02-12 00:00:00

abstract：:Diphenylhydantoin (DPH) is known to be a potent anticonvulsant agent, useful in treating and preventing grand mal seizures. More recently, DPH was reported also to be a potent antiarrhythmic agent acting by means of a depressant action on the heart. The present experiments demonstrated that DPH has also a potent antia...

journal_title：European journal of pharmacology

authors： Lisander B,Jaju B,Wang SC

更新日期：1975-03-01 00:00:00

abstract：:The NMDA receptor is coupled to a cation-selective ion channel, which has been implicated in important brain functions such as long-term potentiation and burst firing, and in neuronal death associated with stroke and epilepsy. We have investigated the binding properties of [3H]MK-801, which binds selectively to the op...

journal_title：European journal of pharmacology

authors： von Euler G,Liu Y

更新日期：1993-05-15 00:00:00

abstract：:The renal vascular effects of dopaminomimetics were studied in the isolated perfused rat kidney after pretreatment with 10(-5) M phenoxybenzamine and 10(-5) M sotalol and after contraction of the vascular bed with prostaglandin F2 alpha (10(-7) to 3 x 10(-6) M). Under these conditions, our criterion for vascular dopam...

journal_title：European journal of pharmacology

authors： Schmidt M,Imbs JL,Giesen EM,Schwartz J

更新日期：1982-10-15 00:00:00

abstract：:Sickness behavior is a series of behavioral and psychological changes that develop in inflammatory disease, including infections and cancers. Administration of the bacterial endotoxin lipopolysaccharide (LPS) induces sickness behavior in rodents. Genipin, an aglycon derived from an iridoid glycoside geniposide extract...

journal_title：European journal of pharmacology

authors： Araki R,Hiraki Y,Yabe T

更新日期：2014-10-15 00:00:00

abstract：:Activated microglia that produce reactive nitrogen species (RNS), inflammatory factors, reactive oxygen species (ROS), and other neurovirulent factors may lead to the development of neurodegenerative diseases. Certain compounds can inhibit the activation of microglia. However, these mechanisms remain unclear. In the p...

journal_title：European journal of pharmacology

authors： Pflüger P,Viau CM,Coelho VR,Berwig NA,Staub RB,Pereira P,Saffi J

更新日期：2016-06-05 00:00:00

abstract：:The authors investigated the effects of spinal and supraspinal administration of the benzodiazepine receptor agonist midazolam alone and with opioids on tests of nociception (tail-flick and hot-plate tests) and motor function (catalepsy) in rats. At the spinal level, the dose-response curves for peak effect and area u...

journal_title：European journal of pharmacology

authors： Luger TJ,Hayashi T,Weiss CG,Hill HF

更新日期：1995-03-06 00:00:00

abstract：:We describe the binding to rat cortex membranes of [125I]iodophenpropit, the first radiolabeled histamine H3 antagonist. The binding of [125I]iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM; Bmax 209 fmol/mg of protein). Specific binding at a concentration of 0.3 nM account...

journal_title：European journal of pharmacology

authors： Jansen FP,Rademaker B,Bast A,Timmerman H

更新日期：1992-07-07 00:00:00

abstract：:Glial cells express thromboxane A(2) receptor, but its physiological role remains unknown. The present study was performed to examine thromboxane A(2) receptor-mediated morphological change in 1321N1 human astrocytoma cells. Thromboxane A(2) receptor agonists U46619 and STA(2) caused a rapid morphological change to sp...

journal_title：European journal of pharmacology

authors： Honma S,Saika M,Ohkubo S,Kurose H,Nakahata N

更新日期：2006-09-18 00:00:00

abstract：:In the present study the antagonism of fentanyl pharmacodynamics was studied in the mouse and the receptor populations mediating the analgesic and lethal effects of fentanyl were examined. Both 1 and 8 days following implantation (s.c.) of a 15 mg naltrexone pellet there was a significant shift to the right of the fen...

journal_title：European journal of pharmacology

authors： Jang Y,Yoburn BC

更新日期：1991-05-17 00:00:00

abstract：:Oxidative stress and inflammation play key roles in the pathogenesis of Multiple sclerosis (MS). Different drugs have been used in the clinical practice, however, there is not a completely effective treatment. Due to its potential therapeutic action, medical ozone represents a promising approach for neurodegenerative ...

journal_title：European journal of pharmacology

authors： Delgado-Roche L,Riera-Romo M,Mesta F,Hernández-Matos Y,Barrios JM,Martínez-Sánchez G,Al-Dalaien SM

更新日期：2017-09-15 00:00:00