Abstract:
:The present study investigated the effect of acidosis (reduction in pH of the Krebs' solution from 7.4 to 6.9) on responses to vasoconstrictors and vasodilators, with a focus on purines, in the rat isolated perfused mesenteric arterial bed. alpha,beta-Methylene ATP (alpha,beta-meATP) (10 microM), a selective P2X receptor agonist, elicited a desensitizing vasocontraction, which was not significantly affected by a reduction in pH to 6.9. Contractions to ATP were also not significantly different at pH 6.9 compared to pH 7.4. In contrast, contractile responses to noradrenaline, methoxamine, and vasopressin were greatly attenuated at pH 6.9 (by 48-83%; P<0.01). At raised tone, vasorelaxations to ADP at P2Y receptors, and to calcitonin gene-related peptide (CGRP), were not different at pH 7.4 and pH 6.9. These data indicate that a reduction in pH (to 6.9) differentially affects responses to vasoconstrictors in the rat mesenteric arterial bed. There is no effect on contractions mediated via P2X receptors, but contractions to noradrenaline, methoxamine and vasopressin are greatly attenuated.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Ralevic Vdoi
10.1016/s0014-2999(00)00631-2keywords:
subject
Has Abstractpub_date
2000-10-06 00:00:00pages
99-107issue
1eissn
0014-2999issn
1879-0712pii
S0014-2999(00)00631-2journal_volume
406pub_type
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