Abstract:
:Previous studies have shown that sertindole (1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl ]-2 imidazolidinone), an atypical antipsychotic drug that is a potent 5-HT2A and dopamine D2 receptor antagonist, preferentially affects mesocorticolimbic rather than mesostriatal dopamine neurons. Using in vivo microdialysis in conscious rats, we investigated the effects of sertindole on dopamine release and metabolism in the striatum and the medial prefrontal cortex. Systemic administration of sertindole dose dependently enhanced dopamine release in the medial prefrontal cortex and the striatum to the same extent.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Watanabe M,Hagino Ydoi
10.1016/s0014-2999(98)00936-4keywords:
subject
Has Abstractpub_date
1999-02-12 00:00:00pages
19-23issue
1eissn
0014-2999issn
1879-0712pii
S0014-2999(98)00936-4journal_volume
367pub_type
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