Are beta-adrenoreceptors involved in the intestinal absorption and tissue distribution of iron in the rat?

abstract：:Corticotropin-releasing factor (CRF) is a neurohormone that mediates stress, anxiety, and affects serotonergic activity. Studies have shown that CRF has dose-dependent opposing effects on serotonergic activity. This effect has been hypothesized to be differentially mediated by CRF(1) and CRF(2) receptors in the dorsal...

journal_title：European journal of pharmacology

authors： Lukkes JL,Forster GL,Renner KJ,Summers CH

更新日期：2008-01-14 00:00:00

abstract：:Membrane currents in response to the application of alpha, beta-methylene ATP (alpha,beta-meATP) were recorded by the whole-cell patch-clamp technique in human embryonic kidney 293 cells transfected with the human P2X3 receptor (HEK 293-hP2X3 cells). Trichloroethanol, the biologically active metabolite of chloral hydr...

journal_title：European journal of pharmacology

authors： Köles L,Wirkner K,Fürst S,Wnendt S,Illes P

更新日期：2000-12-15 00:00:00

abstract：:Curcumin, main compound obtained from rizhoma of Curcuma longa, shows antitumoral, antioxidant, anticarcinogenic and gastric protective properties. Recently, it has been demonstrated that curcumin exerts its gastric protective action due to an increase in gastric nitric oxide (NO) levels. However, it is unknown whethe...

journal_title：European journal of pharmacology

authors： Díaz-Triste NE,González-García MP,Jiménez-Andrade JM,Castañeda-Hernández G,Chávez-Piña AE

更新日期：2014-05-05 00:00:00

abstract：:Since estrogen and selective estrogen receptor modulators can inhibit inflammatory responses, we studied the regulatory role of several selective estrogen receptor modulators on interleukin-6 (IL-6) expression in human retinal pigment epithelial cells (ARPE-19). ARPE-19 cells were exposed to lipopolysaccharide with si...

journal_title：European journal of pharmacology

authors： Paimela T,Hyttinen JM,Viiri J,Ryhänen T,Karvonen MK,Unkila M,Uusitalo H,Salminen A,Kaarniranta K

更新日期：2010-08-25 00:00:00

abstract：:The number of prolactin (PRL) receptors in the hypothalamus and substantia nigra of aged rabbits is significantly lower than the number measured in young animals. The treatment of aged rabbits for 30 days with S-adenosyl-L-methionine (SAM) restored the number of PRL binding sites to levels found in the hypothalamus an...

journal_title：European journal of pharmacology

authors： Muccioli G,Di Carlo R

更新日期：1989-07-18 00:00:00

abstract：:To determine the role of protein kinase C in the regulation of intestinal fluid transport, experiments were performed with the rat jejunum in vivo, using the active phorbol ester, 4-beta-phorbol 12-myristate 13-acetate (PMA), as stimulator of protein kinase C. Intraluminally administered PMA dose dependently reversed ...

journal_title：European journal of pharmacology

authors： Beubler E,Hinterleitner T,Horina G

更新日期：1990-07-17 00:00:00

abstract：:This study was designed to investigate the effect and mechanism of allicin on hyperhomocysteinemia-induced experimental vascular endothelial dysfunction in rats. Fifty male Wistar rats were randomly divided into five groups: the normal control rats (NC), the high-methionine-diet rats (Met), the high-methionine-diet ra...

journal_title：European journal of pharmacology

authors： Liu DS,Gao W,Liang ES,Wang SL,Lin WW,Zhang WD,Jia Q,Guo RC,Zhang JD

更新日期：2013-08-15 00:00:00

abstract：:Adenosine 5'-triphosphate (ATP), beta, gamma-methylene ATP and alpha, beta-methylene ATP produced relaxation of carbachol-precontracted isolated trachealis muscle from the guinea-pig in the presence of indomethacin (2.8 microM) and the adenosine uptake inhibitor S-(4-nitrobenzyl)-6-thioinosine (NBTI; 300 nM). The pote...

journal_title：European journal of pharmacology

authors： Piper AS,Hollingsworth M

更新日期：1996-06-27 00:00:00

abstract：:Quantitative in vitro autoradiographic techniques were used to localize and characterize 125I-labelled human calcitonin gene-related peptide ([125I]hCGRP) binding sites in sections of bovine left anterior descending coronary artery (LAD). Specific high affinity (Kd 0.4 nM) [125I]hCGRP binding sites were localized to t...

journal_title：European journal of pharmacology

authors： Knock GA,Wharton J,Gaer JA,Yacoub MH,Taylor KM,Polak JM

更新日期：1992-09-04 00:00:00

abstract：:The effect of monocrotaline-induced pulmonary hypertension on alpha(1)-adrenoceptor-mediated contractions of pulmonary artery segments was studied. In control and monocrotaline-treated rats, noradrenaline evoked concentration-dependent contractions of the pulmonary artery. There was no change in the potency and affini...

journal_title：European journal of pharmacology

authors： Oriowo MA,Chandrasekhar B,Kadavil EA

更新日期：2003-12-15 00:00:00

abstract：:Mastoparan activated membrane-bound guanylate cyclase and potentiated the effect of atrial natriuretic factor (ANF) and ATP on guanylate cyclase activity in rat lung membranes. Mastoparan is a cationic, amphiphilic tetradecapeptide with an amidated carboxyl terminus. It takes the alpha-helical conformation upon intera...

journal_title：European journal of pharmacology

authors： Song DL,Chang GD,Ho CL,Chang CH

更新日期：1993-11-15 00:00:00

abstract：:Glucocorticoids can reverse hemodynamic disturbances and dependence on catecholamines in septic shock. The relevant beneficial mechanisms of steroids in septic shock are unknown, although inducible nitric oxide synthase could account for them. The aim of this study was to compare the effects of dexamethasone, a glucoc...

journal_title：European journal of pharmacology

authors： Mansart A,Bollaert PE,Levy B,Nicolas MB,Mallié JP

更新日期：2003-08-15 00:00:00

abstract：:Plants are a natural source of bioactive compounds such as secondary metabolites. These molecules, also called phytochemicals, are fundamental for plant survival and often show therapeutic properties used for the treatment of human diseases. Asperuloside is a secondary metabolite which belongs to iridoid glycosides an...

journal_title：European journal of pharmacology

authors： Manzione MG,Martorell M,Sharopov F,Bhat NG,Kumar NVA,Fokou PVT,Pezzani R

更新日期：2020-09-15 00:00:00

abstract：:A neonatal cerebral cortical lesion was made in rats and the effects of diazepam on ultrasonic isolation calls in pups and footshock-elicited ultrasonic distress calls in young adult rats were assessed. There was no indication that the cortical lesion influenced the production of the ultrasonic distress calls in eithe...

journal_title：European journal of pharmacology

authors： Naito H,Arishima K,Tonoue T

更新日期：1995-01-16 00:00:00

abstract：:The effects of 1,4-dihydropyridine derivatives on divalent cation transients and catecholamine release stimulated by either high K+ or the nicotinic receptor agonist dimethyl-phenyl-piperazinium (DMPP) have been compared in bovine adrenal chromaffin cells. The activation of Ca2+ entry pathways was followed by measurin...

journal_title：European journal of pharmacology

authors： López MG,Fonteríz RI,Gandía L,de la Fuente M,Villarroya M,García-Sancho J,García AG

更新日期：1993-10-15 00:00:00

abstract：:The correlation between the Phosphoinositide 3-kinase (PI3K) axis and crucial mechanisms involved in the maintenance of the neoplastic nature of multiple myeloma (MM) has recently evolved a general agreement that PI3K inhibition-based therapies could construct an exciting perspective for the future treatment strategie...

journal_title：European journal of pharmacology

authors： Safaroghli-Azar A,Bashash D,Kazemi A,Pourbagheri-Sigaroodi A,Momeny M

更新日期：2019-01-05 00:00:00

abstract：:In normotensive rats, we have previously demonstrated a role of brain mineralocorticoid receptors in blood pressure and renal function control. In the present study, the coordinate cardiovascular and renal effects of brain mineralocorticoid receptor blockade were examined by intracerebroventricular (i.c.v.) administra...

journal_title：European journal of pharmacology

authors： Rahmouni K,Sibug RM,De Kloet ER,Barthelmebs M,Grima M,Imbs JL,De Jong W

更新日期：2002-02-02 00:00:00

abstract：:Acetylsalicylic acid (ASA) causes adverse haemorrhagic reactions in the upper gastrointestinal (GI) tract, and previous results have suggested that combination therapy with 2-amino-2-(hydroxymethyl)-1,3-propanediol (Tris) could provide protection in this scenario. Based on this hypothesis, our aim was to develop a new...

journal_title：European journal of pharmacology

authors： Varga G,Lajkó N,Ugocsai M,Érces D,Horváth G,Tóth G,Boros M,Ghyczy M

更新日期：2016-06-15 00:00:00

abstract：:A series of potent bombesin antagonists based on the reduced C-terminal peptide bond modification which in the past resulted in the first really potent antagonists are compared for effects on bombesin-stimulated amylase release from and binding to rat and guinea pig pancreatic acini. It was found that the original mem...

journal_title：European journal of pharmacology

authors： Coy D,Wang LH,Jiang NY,Jensen R

更新日期：1990-11-06 00:00:00

abstract：:The constitutive androstane receptor (CAR, NR1I3) has a central role in detoxification processes, regulating the expression of a set of genes involved in metabolism. The dual role of NR1I3 as both a xenosensor and as a regulator of endogenous energy metabolism has recently been accepted. Here, we investigated the mech...

journal_title：European journal of pharmacology

authors： Kachaylo EM,Yarushkin AA,Pustylnyak VO

更新日期：2012-03-15 00:00:00

abstract：:The effects of indapamide on contractile responses in various isolated artery rings and on spontaneous mechanical activity in portal vein segments were investigated. Arteries used were: rabbit aorta, mesenteric (fifth branch), femoral and basilar, and sheep coronary arteries. 45Ca2+ uptake was also analysed in rabbit ...

journal_title：European journal of pharmacology

authors： Del Rio M,Chulia T,Gonzalez P,Tejerina T

更新日期：1993-11-30 00:00:00

abstract：:Brefelamide is an aromatic amide isolated from Dictyostelium cellular slime molds. We found that brefelamide has a potent inhibitory growth effect measured by MTT assay in 1321N1 human astrocytoma cells. The inhibition was associated with reduced phosphorylation of extracellular signal-regulated kinase (ERK). Brefelam...

journal_title：European journal of pharmacology

authors： Honma S,Saito M,Kikuchi H,Saito Y,Oshima Y,Nakahata N,Yoshida M

更新日期：2009-08-15 00:00:00

abstract：:SB203580 is the prototypical p38 MAPK inhibitor; however it cannot be used clinically due to liver toxicity. We developed a structural analogue of SB203580 - ML3403 - with equal in vitro and ex vivo p38alpha MAPK inhibition as SB203580, but with reduced activity towards liver cytochrome P450 enzymes. In addition, we d...

journal_title：European journal of pharmacology

authors： Munoz L,Ramsay EE,Manetsch M,Ge Q,Peifer C,Laufer S,Ammit AJ

更新日期：2010-06-10 00:00:00

abstract：:In vitro studies have provided evidence that Cl(-) ion currents are important for activation of vascular smooth muscle contraction. The stilbene, 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), disrupts Cl(-) metabolism by blocking Cl(-) channels and by inhibiting Cl(-) bicarbonate exchange. The aims of thi...

journal_title：European journal of pharmacology

authors： Lamb FS,Kooy NW,Lewis SJ

更新日期：2000-08-11 00:00:00

abstract：:Five different muscarinic receptor subtypes can be distinguished by the differences in their amino acid sequence, the coupled signal transduction system, pharmacological binding properties and activation of ionic fluxes. The present study served to characterize the binding profile of muscarinic receptors in human colo...

journal_title：European journal of pharmacology

authors： Kopp R,Lambrecht G,Mutschler E,Moser U,Tacke R,Pfeiffer A

更新日期：1989-10-17 00:00:00

abstract：:Choline acetyltransferase activity was measured in rats treated with daily injections of ethanol (0.1 g/kg body wt) and or dexamethasone (1 mg/kg body wt) for 5 consecutive days. Ethanol produced a biphasic reduction of choline acetyltransferase activity in rat cerebral cortex, which at most time points was further de...

journal_title：European journal of pharmacology

authors： Wattanathorn J,Kotchabhakdi N,Casalotti SO,Baldwin BA,Govitrapong P

更新日期：1996-10-10 00:00:00

abstract：:Tryptase, a serine protease synthesized by and stored in mast cells, is implicated as an important mediator in the pathogenesis of airway inflammation. In this study, tryptase was evaluated for its ability to induce microvascular leakage into the airways of guinea pigs. Dose- and time-dependent increases in airway mic...

journal_title：European journal of pharmacology

authors： Greenfeder S,Sehring S,McHugh N,Corboz M,Rivelli M,Anthes JC,Billah M,Egan RW,Chapman RW

更新日期：2001-05-11 00:00:00

abstract：:A specific binding site for the antiepileptic drug levetiracetam (2S-(oxo-1-pyrrolidinyl)butanamide, Keppra) in rat brain, referred to as the levetiracetam binding site, was discovered several years ago. More recently, this binding site has been identified as the synaptic vesicle protein 2A (SV2A), a protein present i...

journal_title：European journal of pharmacology

authors： Gillard M,Chatelain P,Fuks B

更新日期：2006-04-24 00:00:00

abstract：:Aminoguanidine is an inhibitor of inducible nitric oxide synthase (iNOS) and is of potential clinical usefulness. Treatment of mice with anti-Fas antibodies (150 microg/kg, i.v.) induced elevation of plasma alanine aminotransferase activity at 4 h and this elevation was inhibited by pretreatment of mice with aminoguan...

journal_title：European journal of pharmacology

authors： Okamoto T,Okabe S

更新日期：2000-09-08 00:00:00

abstract：:Glucocorticoids inhibit inducible-type NO synthase activity in a variety of cell types. We report here that proteins recovered from the medium of dexamethasone-treated J774 macrophages (1, 10, 100 microg/ml) inhibited lipopolysaccharide-stimulated nitrite generation by 10.0 +/- 3.0%, 32.3 +/- 5.3% and 55.0 +/- 6.0%, r...

journal_title：European journal of pharmacology

authors： D'Acquisto F,Cicatiello L,Iuvone T,Ialenti A,Ianaro A,Esumi H,Weisz A,Carnuccio R

更新日期：1997-11-19 00:00:00