Effect of Ca2+ entry blockers on myosin light-chain kinase and protein kinase C.

Abstract:

:Thirteen Ca2+ entry blockers were compared with respect to their inhibitory effects on the activity of smooth muscle myosin light-chain kinase and smooth muscle protein kinase C, and the Ca2+-induced contraction of basilar artery rings. Comparison of the IC50 values obtained for these compounds, suggests that with the exception of ferdiline inhibition of the enzymes does not contribute to vascular smooth muscle relaxation.

journal_name

Eur J Pharmacol

authors

Schächtele C,Wagner B,Rudolph C

doi

10.1016/0014-2999(89)90410-x

subject

Has Abstract

pub_date

1989-04-12 00:00:00

pages

151-5

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(89)90410-X

journal_volume

163

pub_type

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