Comparison of short-term administration of sertindole, clozapine and haloperidol on the inactivation of midbrain dopamine neurons in the rat.

abstract：:Three agents with K+ channel blocking activity, procaine, 4-aminopyridine (4-AP) and tetraethylammonium (TEA), were tested for inhibition of vasorelaxation and 86Rb+ efflux induced by cromakalim (BRL 34915), pinacidil and nicorandil in rabbit isolated mesenteric artery. The potency order for inhibition of vasorelaxati...

journal_title：European journal of pharmacology

authors： Wilson C,Coldwell MC,Howlett DR,Cooper SM,Hamilton TC

更新日期：1988-08-02 00:00:00

abstract：:When injected directly into the tail, U50,488H is a potent analgesic in the tailflick assay (ED50 3.1 micrograms). The analgesic activity is lost if the radiant heat is focused 1 cm away from the site of injection. The kappa 1-opioid receptor antagonist nor-binaltorphimine given systemically reverses the local analges...

journal_title：European journal of pharmacology

authors： Kolesnikov Y,Jain S,Wilson R,Pasternak GW

更新日期：1996-08-29 00:00:00

abstract：:Substance-related and addictive disorders (SRADs) are characterized by compulsive drug use and recurrent relapse. The persistence of pathological drug-related memories indisputably contributes to a high propensity to relapse. Hence, strategies to disrupt reconsolidation of drug reward memory are currently being pursue...

journal_title：European journal of pharmacology

authors： Rulan D,Zhenbang Y,Yipu Z,Yuan G,Galaj E,Xiaorui S,Wenshuya L,Jiaqi L,Yan Z,Chang Y,Xi Y,Li S,Yixiao L,Haishui S

更新日期：2021-01-24 00:00:00

abstract：:The influence of the membrane environment on the alpha 1-adrenoceptor has been investigated by examining the effect of phospholipase digestion on the binding of [3H]prazosin to aortic and hepatic membranes. Membrane digestion by phospholipase A2 and phospholipase C was found to markedly reduce prazosin binding to the ...

journal_title：European journal of pharmacology

authors： Shreeve SM,Valliere JE

更新日期：1992-05-12 00:00:00

abstract：:Interactions between cannabinoid CB(1) and GABA receptors and ligands were investigated in the myenteric plexus-longitudinal muscle of the guinea pig ileum. Electrically evoked contractions of the myenteric plexus-longitudinal muscle were inhibited by the cannabinoid receptor agonist CP55,940 ((-)-cis-3-[2-Hydroxy-4-(...

journal_title：European journal of pharmacology

authors： Begg M,Molleman A,Parsons M

更新日期：2002-01-02 00:00:00

abstract：:27-O-Caffeoyl myricerone (50-235) is a nonpeptide endothelin receptor antagonist which is highly selective for the endothelin ETA receptor subtype. In order to determine which functional groups in 50-235 are essential for its activity, we examined the potencies of 50-235 and its derivatives to inhibit [125I]endothelin...

journal_title：European journal of pharmacology

authors： Mihara S,Sakurai K,Nakamura M,Konoike T,Fujimoto M

更新日期：1993-10-15 00:00:00

abstract：:Changes in autonomic receptor systems (alpha- and beta-adrenoceptors and muscarinic receptors) were compared in the aging and failing human heart. In both settings responsiveness of beta-adrenoceptors and all other receptor systems that evoke their effects via cyclic AMP accumulation was diminished. Muscarinic recepto...

journal_title：European journal of pharmacology

authors： Brodde OE,Leineweber K

更新日期：2004-10-01 00:00:00

abstract：:Identification of natural products that have antitumor activity is invaluable to the chemoprevention and therapy of cancer. The embryos of lotus (Nelumbo nucifera) seeds are consumed in beverage in some parts of the world for their presumed health-benefiting effects. In this report we studied the effects of neferine, ...

journal_title：European journal of pharmacology

authors： Zhang X,Liu Z,Xu B,Sun Z,Gong Y,Shao C

更新日期：2012-02-29 00:00:00

abstract：:The role of presynaptic acetylcholine receptors and Ca2+ channels in the regenerative acetylcholine release was studied in the cut muscle preparation of mouse phrenic nerve hemidiaphragm. The regenerative release shown as a prolonged endplate depolarization was evoked by stimulation of the nerve with a train of pulse ...

journal_title：European journal of pharmacology

authors： Hong SJ,Chang CC

更新日期：1989-03-14 00:00:00

abstract：:Alcuronium is known to stabilize allosterically the binding of the muscarinic antagonist N-methylscopolamine to muscarinic M2 receptors and thus to elevate the equilibrium binding of N-methylscopolamine in homogenized cardiac tissue. In order to check for a functional consequence of this effect, the action of alcuroni...

journal_title：European journal of pharmacology

authors： Maass A,Kostenis E,Mohr K

更新日期：1995-01-05 00:00:00

abstract：:Male mice from 14 strains were injected i.p. with tremorine (3.0 mg/kg) or oxotremorine (0.15 or 0.1 mg/kg). Large inter-strain differences in the degree and duration of the subsequent hypothermia were noted. 2 strains, BALB/c and Simpson, were particularly sensitive to the hypothermic effect of oxotremorine. The offs...

journal_title：European journal of pharmacology

authors： Lush IE,Andrews KM

更新日期：1978-05-01 00:00:00

abstract：:Luminal exposure of mouse ileal mucosal sheets in vitro to 0.3% Triton X-100 for 10 min resulted in a 45.3 +/- 4.4% decrease in tissue resistance (Rt). Luminal pretreatment of tissue with epidermal growth factor (EGF, 30 nM) reduced the Triton X-100-induced decrease in Rt to 10.2 +/- 3.5%. This effect of luminal EGF w...

journal_title：European journal of pharmacology

authors： Rao R,Porreca F

更新日期：1996-05-15 00:00:00

abstract：:Several anticancer drugs are ineffective against brain tumor and do not impact patient survival because they fail to cross the blood-brain tumor barrier (BTB) effective levels. One such agent temozolomide is commonly used in brain tumor patients, which works better when combined with radiation or other anticancer agen...

journal_title：European journal of pharmacology

authors： Ningaraj NS,Sankpal UT,Khaitan D,Meister EA,Vats T

更新日期：2009-01-14 00:00:00

abstract：:Diazepam (10(-5)-3 X 10(-4) M) selectively enhanced the negative inotropic responses of guinea-pig atria and the relaxation of guinea-pig taenia coli caused by adenosine and ATP. In the atria, the effect of 2-chloroadenosine, a stable analog of adenosine, was not affected by diazepam. Segments of guinea-pig atria or t...

journal_title：European journal of pharmacology

authors： Moritoki H,Fukuda H,Kotani M,Ueyama T,Ishida Y,Takei M

更新日期：1985-07-11 00:00:00

abstract：:In the present study, we reported the metabolic effects of salidroside, one of the active components of Rhodiola Rosea, on skeletal muscle cells. Salidroside dose-dependently stimulated glucose uptake in differentiated L6 rat myoblast cells. Inhibitor of AMP-activated protein kinase (AMPK) by pretreating the cells wit...

journal_title：European journal of pharmacology

authors： Li HB,Ge YK,Zheng XX,Zhang L

更新日期：2008-07-07 00:00:00

abstract：:Rats were given powdered diet containing L-DOPA (together with the peripheral decarboxylase inhibitor carbidopa) for a period of 6 months. The estimated daily intake was in the range 20-30 mg/kg. Initially, at 1 week and 1 month, L-DOPA-fed rats exhibited enhanced spontaneous locomotor activity, but this fell to withi...

journal_title：European journal of pharmacology

authors： Pycock C,Dawbarn D,O'Shaughnessy C

更新日期：1982-04-23 00:00:00

abstract：:The effects of 3-(3-iodo-4-aminobenzyl)-8-(4-oxyacetate)-1-propylxanthine (I-ABOPX; BW-A522), which has nanomolar affinity for the recently cloned human and sheep adenosine A3 receptor, on the putative A3 receptor mediated hypotensive response to N6-2-(4-aminophenyl)ethyl adenosine (APNEA) in the rat have been investi...

journal_title：European journal of pharmacology

authors： Fozard JR,Hannon JP

更新日期：1994-02-03 00:00:00

abstract：:In rat carotid arteries isolated 2 weeks after balloon denudation, a significant neointima developed with little change in medial size. Associated with this neointimal hyperplasia was a marked decrease in contraction to various agents including angiotensins I and II, big endothelin-1, endothelin-1, norepinephrine, phe...

journal_title：European journal of pharmacology

authors： Antonaccio MJ,Normandin D,Ferrer P

更新日期：1994-04-11 00:00:00

abstract：:Of eleven aporphine analogues tested on striatal adenylate cyclase only (-)-apomorphine and (+/-)-N-n-propyl-norapomorphine (+/-(NPA)) were effective in stimulating the cyclase from rat brain. Inactive compounds included (+/-)-isoapomorphine, (-)-1,2-dihydroxyaporphine and (+/-)-10-hydroxy-N-n-propylnoraporphine. (+)-...

journal_title：European journal of pharmacology

authors： Miller RJ,Kelly PH,Neumeyer JL

更新日期：1976-01-01 00:00:00

abstract：:This study investigates the effect and the underlying mechanism of 2',3-dihydroxy-5-methoxybiphenyl (RIR-2), a lignan extracted from the roots of Rhaphiolepis indica (L.) Lindl. ex Ker var. tashiroi Hayata ex Matsum. & Hayata (Rosaceae), on N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced respiratory burst...

journal_title：European journal of pharmacology

authors： Liao HR,Chen IS,Liu FC,Lin SZ,Tseng CP

更新日期：2018-06-15 00:00:00

abstract：:Effects of chelerythrine and bisindolylmaleimide I on action potential duration and on voltage-activated K(+) and Ca(2+) currents in rat ventricular myocytes were studied using perforated patch-clamp technique. The action potentials were markedly prolonged after application of 20 microM chelerythrine or 100 nM bisindo...

journal_title：European journal of pharmacology

authors： Voutilainen-Myllylä S,Tavi P,Weckström M

更新日期：2003-04-11 00:00:00

abstract：:The melanocortin subtype 4 (MC4) receptor has been postulated to be involved in stress and stress-related behavior. We made use of melanocortin MC4 receptor agonists and antagonist to investigate the relationship between the melanocortin MC4 receptor and stress related disorders. The nonspecific melanocortin receptor ...

journal_title：European journal of pharmacology

authors： Chaki S,Ogawa S,Toda Y,Funakoshi T,Okuyama S

更新日期：2003-08-01 00:00:00

abstract：:H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) is a compound characterized in vitro as a potent and selective inhibitor of protein kinase A (PKA). In this study, we found that H89 reduced the phosphorylation of the myosin regulatory light chain (MRLC) at Thr-18/Ser-19 and induced disassembly of stre...

journal_title：European journal of pharmacology

authors： Umeda D,Yamada K,Tachibana H

更新日期：2008-08-20 00:00:00

abstract：:Glycine displaces [3H]CGP-39653 ([3H]D,L-(E)-2-amino-4-propyl-5-phosphono-3-pentenoic acid) binding to the glutamate recognition site with both high and low affinity. We reported previously that chronic treatment with antidepressants reduced the proportion of high to low affinity sites, or, even eliminated the high af...

journal_title：European journal of pharmacology

authors： Nowak G,Legutko B,Skolnick P,Popik P

更新日期：1998-01-26 00:00:00

abstract：:Experiments were designed to determine whether or not ketanserin (R 41 468) antagonizes the augmentation by 5-hydroxytryptamine of contractions evoked in isolated arteries by non-adrenergic vasoconstrictor substances. Rings of rabbit femoral arteries were studied under isometric conditions in organ chambers filled wit...

journal_title：European journal of pharmacology

authors： Van Nueten JM,Janssen PA,De Ridder A,Vanhoutte PM

更新日期：1982-02-05 00:00:00

abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was incidentally administered to pregnant marmosets during the whole gestational period, except for the last 15 days before term. The infant monkeys were killed 5 months after birth, and dopamine and its metabolites were measured in the striatum and the nucleus accum...

journal_title：European journal of pharmacology

authors： Pérez-Otaño I,Oset C,Trinidad Herrero M,Luquin MR,Kupsch A,Oertel W,Obeso JA,Del Río J

更新日期：1992-07-07 00:00:00

abstract：:Proliferation and migration of vascular smooth muscle cells (VSMCs) play crucial roles in the development of vascular restenosis. Our previous study showed that CCN4, namely Wnt1 inducible signaling pathway protein 1 (WISP1), significantly promotes proliferation and migration of rat VSMCs, but its mechanism remains un...

journal_title：European journal of pharmacology

authors： Lu S,Liu H,Lu L,Wan H,Lin Z,Qian K,Yao X,Chen Q,Liu W,Yan J,Liu Z

更新日期：2016-10-05 00:00:00

abstract：:The affinity of LY-171555 (quinpirole) and BHT-920 for both states of rat striatal dopamine D-1 and D-2 receptors was determined. Although these drugs have different pharmacological effects in experimental animals, we found that they had similar affinities for both D-1 and D-2 receptors. ...

journal_title：European journal of pharmacology

authors： Ferré S,Guix T,Sallés J,Cuffí L,Badia A,Casas M

更新日期：1989-07-18 00:00:00

abstract：:Multidrug resistance phenotype in mammalian cells is often correlated with overexpression of P-glycoprotein or Multidrug Resistance-Associated protein (MRP(1)). Both proteins are energy-dependent drug efflux pumps that efficiently reduce the intracellular accumulation and hence the cytotoxicity of many natural cytotox...

journal_title：European journal of pharmacology

authors： Marbeuf-Gueye C,Salerno M,Quidu P,Garnier-Suillerot A

更新日期：2000-03-17 00:00:00

abstract：:Several studies have shown that glycine transporter 1 (GlyT1) inhibitors have anxiolytic actions. There are two types of glycine receptor: the strychnine-sensitive glycine receptor (GlyA) and the strychnine-insensitive glycine receptor (GlyB); however, which receptor is the main contributor to the anxiolytic actions o...

journal_title：European journal of pharmacology

authors： Komatsu H,Furuya Y,Sawada K,Asada T

更新日期：2015-01-05 00:00:00