BW-A522 blocks adenosine A3 receptor-mediated hypotensive responses in the rat.

abstract：:The antinociceptive effect of nitrous oxide (N(2)O) is dependent on nitric oxide (NO); however, the next step in the pathway activated by NO is undetermined. The present study was conducted to test the hypothesis that a N(2)O action involves sequential activation of NO synthase, soluble guanylyl cyclase and protein ki...

journal_title：European journal of pharmacology

authors： Zhang Y,Quock LP,Chung E,Ohgami Y,Quock RM

更新日期：2011-03-11 00:00:00

abstract：:Hepatocellular carcinoma (HCC), as the commonest type in liver cancer, is in urgent need for better treatment target due to its high mortality and poor prognosis. The involvement of angiogenesis in HCC has been identified by multiple studies, but the underlying mechanism remains unclear. Long non-coding RNAs (LncRNAs)...

journal_title：European journal of pharmacology

authors： Li W,Fu Q,Man W,Guo H,Yang P

更新日期：2019-04-15 00:00:00

abstract：:We have recently proposed that retinoic acid receptor (NR1B) is a promising target of neuroprotective therapy for intracerebral hemorrhage, since pretreatment of mice with an NR1B1/NR1B2 agonist Am80 attenuated various pathological and neurological abnormalities associated with the disease. In the present study we fur...

journal_title：European journal of pharmacology

authors： Matsushita H,Hijioka M,Hisatsune A,Isohama Y,Shudo K,Katsuki H

更新日期：2012-05-15 00:00:00

abstract：:Ouabain- and bumetanide-resistant potassium fluxes were measured in human erythrocytes incubated in a medium containing calcium and a calcium ionophore. Pharmacological concentrations of rat atrial natriuretic peptide stimulated these fluxes. Although human erythrocytes lack atrial natriuretic peptide receptors, our r...

journal_title：European journal of pharmacology

authors： Esparza N,Díez J

更新日期：1989-07-18 00:00:00

abstract：:The outcome for both in-hospital and out-of hospital cardiac arrest remains dismal. Vasopressors are used to increase coronary perfusion pressure and thus facilitate return of spontaneous circulation during cardiopulmonary resuscitation. However, they are associated with a number of potential adverse effects and may d...

journal_title：European journal of pharmacology

authors： Stefaniotou A,Varvarousi G,Varvarousis DP,Xanthos T

更新日期：2014-07-05 00:00:00

abstract：:We have recently shown that responses to pressor nerve stimulation in the pithed rat are mediated by α(1A)- and α(1D)-adrenoceptors, with no evidence for α(2)-adrenoceptor involvement, and that responses previously identified as α(2)-adrenoceptor mediated are actually α(1D)-adrenoceptor mediated. We have now re-examin...

journal_title：European journal of pharmacology

authors： Docherty JR

更新日期：2012-03-15 00:00:00

abstract：:Nitric oxide (10 ppm) inhaled by pigs before or during endotoxin shock induced by an infusion of E. coli lipopolysaccharide. Nitric oxide inhalation selectively attenuated pulmonary hypertension during endotoxin infusion without influencing mean arterial blood pressure and cardiac output. Upon cessation of nitric oxid...

journal_title：European journal of pharmacology

authors： Weitzberg E,Rudehill A,Lundberg JM

更新日期：1993-03-16 00:00:00

abstract：:Pretreatment with the catecholamine precursor L-DOPA but not the narcotic antagonist naloxone suppressed the tremorigenic effect of oxotremorine in mice. However, when animals were pretreated with both L-DOPA and several different doses of naloxone, there was a dose-related potentiation of the antitremor effect of L-D...

journal_title：European journal of pharmacology

authors： Quock RM,Lucas TS

更新日期：1983-11-25 00:00:00

abstract：:Accumulating evidence indicates the role of microglial activation and sustained neuroinflammation in the pathogenesis of cognitive dysfunction, a common feature associated with depressive disorders. It also indicates the role of Wnt/β-catenin pathway in regulation of microglia-mediated neuroinflammation. Amisulpride e...

journal_title：European journal of pharmacology

authors： Mohamed AM,Habib MZ,Ebeid MA,Abdelraouf SM,El Faramawy Y,Aboul-Fotouh S,Magdy Y

更新日期：2020-10-15 00:00:00

abstract：:The effects of Bay K 8644 and of nifedipine on histamine-induced mechanical and electrical responses were studied in the longitudinal smooth muscle of the ileum and in the taenia coli isolated from the guinea-pig. Nifedipine (10(-9)-10(-7) M) depressed the tonic and phasic components of histamine contraction. Phasic t...

journal_title：European journal of pharmacology

authors： Morel N,Hardy JP,Godfraind T

更新日期：1987-03-03 00:00:00

abstract：:Galangin, a flavonol derived from Alpinia officinarum Hance and used as food additives in southern China, induces apoptosis and autophagy to suppress the proliferation of HepG2 cells. In this study, we demonstrated that galangin induced autophagy by increasing the ratio of AMP/TAN in HepG2 cells. It stimulated the pho...

journal_title：European journal of pharmacology

authors： Zhang H,Li N,Wu J,Su L,Chen X,Lin B,Luo H

更新日期：2013-10-15 00:00:00

abstract：:The nicotinic acetylcholine receptors in the rat stomach were characterized by means of a radioligand binding assay with (-)-[3H]nicotine as ligand. Saturation binding studies on the gastric fundus membranes revealed the presence of two binding sites with dissociation constant (KD) values of 3.1 and 289 nM, and maximu...

journal_title：European journal of pharmacology

authors： Nishikawa H,Taniguchi T,Ninomiya H,Fujiwara M

更新日期：1988-01-27 00:00:00

abstract：:The 5-lipoxygenase inhibitors WY-50,295 tromethamine, A-64,077, L-663,536 and ICI-207,968 were compared in a reverse passive Arthus reaction-induced pleurisy model of eicosanoid biosynthesis in the rat. When a 1 h pretreatment schedule was employed, all four inhibitors equivalently blocked leukotriene B4 (LTB4) produc...

journal_title：European journal of pharmacology

authors： Berkenkopf JW,Weichman BM

更新日期：1991-01-25 00:00:00

abstract：:The distribution of the binding of [3H]GR65630 (0.2 nM) to putative 5-HT3 recognition sites in the brain of the common marmoset was assessed using autoradiography. Specific binding was heterogeneously distributed with the highest densities found in discrete nuclei of the lower medulla (nucleus tractus solitarii, dorsa...

journal_title：European journal of pharmacology

authors： Jones DN,Barnes NM,Costall B,Domeney AM,Kilpatrick GJ,Naylor RJ,Tyers MB

更新日期：1992-04-29 00:00:00

abstract：:MK-801 (a potent non-competitive antagonist of N-methyl-D-aspartic acid-mediated events) in subcutaneous doses of 0.1 and 0.2 mg/kg increased the threshold for electroconvulsions and in doses of 0.0031 and 0.0125 mg/kg enhanced the protective activity of valproate against maximal electroshock-induced convulsions in mi...

journal_title：European journal of pharmacology

authors： Urbańska E,Dziki M,Kleinrok Z,Czuczwar SJ,Turski WA

更新日期：1991-08-06 00:00:00

abstract：:Intrastriatal injection of kainic acid (5 nmoles) to rats led to severe destruction of nerve cell bodies throughout the caudate-putamen complex and an extensive proliferation of glial cells. Lesioned striata displayed a significant 23% loss of beta-adrenoceptor binding sites 21--24 days after injection of kainic acid....

journal_title：European journal of pharmacology

authors： Nahorski SR,Howlett DR,Redgrave P

更新日期：1979-12-07 00:00:00

abstract：:The present paper describes the effect of beta-phenylethylamine and its metabolites phenylethanolamine, tyramine, acetyl-phenylethylamine and phenylacetaldehyde on the dopaminergic nigrostriatal system. The rotational behavioural response to the i.v. injection of these drugs was quantified in animals with a unilateral...

journal_title：European journal of pharmacology

authors： Barroso N,Rodriguez M

更新日期：1996-02-22 00:00:00

abstract：:Protective effects of OP-2507 [15-cis-(4-propylcyclohexyl)-16,17,18,19,20-pentanor-9-deoxy -9 alpha, 6-nitrilo-PGF1 methyl ester] against cerebral anoxia and edema were investigated in a variety of experimental models in mice and rats. OP-2507 given s.c. or p.o. led to a consistent and dose-dependent prolongation of s...

journal_title：European journal of pharmacology

authors： Masuda Y,Ochi Y,Ochi Y,Karasawa T,Hatano N,Kadokawa T,Okegawa T

更新日期：1986-04-29 00:00:00

abstract：:Amyloid-beta (Abeta) plaques are a pathological hallmark of Alzheimer's disease and a current target for positron emission tomography (PET) imaging agents. Whilst [(11)C]-PiB is currently the most widely used PET ligand in clinic, a novel family of benzoxazole compounds have shown promise as Abeta imaging agents; part...

journal_title：European journal of pharmacology

authors： Fodero-Tavoletti MT,Mulligan RS,Okamura N,Furumoto S,Rowe CC,Kudo Y,Masters CL,Cappai R,Yanai K,Villemagne VL

更新日期：2009-09-01 00:00:00

abstract：:In rat brain cortex slices, ethanol was three times more potent in inhibiting [3H]noradrenaline ([3H]NA) release evoked by N-methyl-D-aspartate (NMDA) than in inhibiting the release evoked by kainic acid. Methanol, 1-propanol, 1-butanol, 1-pentanol and 1-hexanol shared the inhibitory property of ethanol on NMDA-evoked...

journal_title：European journal of pharmacology

authors： Fink K,Göthert M

更新日期：1990-11-27 00:00:00

abstract：:Identification of natural products that have antitumor activity is invaluable to the chemoprevention and therapy of cancer. The embryos of lotus (Nelumbo nucifera) seeds are consumed in beverage in some parts of the world for their presumed health-benefiting effects. In this report we studied the effects of neferine, ...

journal_title：European journal of pharmacology

authors： Zhang X,Liu Z,Xu B,Sun Z,Gong Y,Shao C

更新日期：2012-02-29 00:00:00

abstract：:A simple dual detector coincidence system was used to measure the binding of [11C]carfentanil and [11C]diprenorphine to opiate receptors in normal volunteers before and after the administration of naloxone. Total radioactivity without naloxone and the ratio of total/non-specific radioactivity was 2 times greater for [...

journal_title：European journal of pharmacology

authors： Villemagne VL,Frost JJ,Dannals RF,Lever JR,Tanada S,Natarajan TK,Wilson AA,Ravert HT,Wagner HN Jr

更新日期：1994-05-12 00:00:00

abstract：:The present studies were conducted to investigate the role of 5-HT2C and 5-HT2B receptors in the generation of pentylenetetrazol and electroshock-evoked seizures. The 5-HT2C/2B receptor-preferring agonist 1-(m-chlorophenyl)-piperazine (mCPP; 2.5-7 mg/kg i.p.) weakly elevated seizure threshold in the mouse (but not the...

journal_title：European journal of pharmacology

authors： Upton N,Stean T,Middlemiss D,Blackburn T,Kennett G

更新日期：1998-10-16 00:00:00

abstract：:The effects of the metabotropic glutamate (mGlu) receptor agonists (+/-)-trans-1-aminocyclopentane-1,3-dicarboxylic acid (trans-ACPD) or 1S,3R-ACPD on gamma-aminobutyric acid (GABA)-mediated inhibitory synaptic responses have been investigated in vitro in CA1 pyramidal cells of rat hippocampal slices. Bath application...

journal_title：European journal of pharmacology

authors： Jouvenceau A,Dutar P,Billard JM

更新日期：1995-08-04 00:00:00

abstract：:In both rats and mice a single large dose of methylenedioxymethylamphetamine (MDMA; 25 mg/kg i.p.) caused a fall 3 h after injection in the content of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in cortex, a fall in noradrenaline in hippocampus and cerebellum, and a rise in dopamine (DA) but fal...

journal_title：European journal of pharmacology

authors： Logan BJ,Laverty R,Sanderson WD,Yee YB

更新日期：1988-08-02 00:00:00

abstract：:Specific antagonists of platelet-activating factor (PAF) receptors inhibit platelet aggregation and thromboxane synthesis. These two processes have been implicated in the course of diabetic retinopathy. We assessed the effect of a specific PAF receptor antagonist, WEB 2086-BS (3-(4-(2-chlorophenyl)-9-methyl-6H-thieno(...

journal_title：European journal of pharmacology

authors： de la Cruz JP,Moreno A,Ruiz-Ruiz MI,García-Campos J,Sánchez de la Cuesta F

更新日期：1998-10-30 00:00:00

abstract：:We recently observed that the 5-hydroxytryptamine (5-HT)(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)-cycloh exanecarboxamide (WAY 100635) enhanced antipsychotic-induced catalepsy, which we hypothesized to be due to a blockade of tonic 5-HT(1A) receptor activation. Here, we ex...

journal_title：European journal of pharmacology

authors： Prinssen EP,Koek W,Kleven MS

更新日期：2000-04-28 00:00:00

abstract：:The present study investigated the effect of acidosis (reduction in pH of the Krebs' solution from 7.4 to 6.9) on responses to vasoconstrictors and vasodilators, with a focus on purines, in the rat isolated perfused mesenteric arterial bed. alpha,beta-Methylene ATP (alpha,beta-meATP) (10 microM), a selective P2X recep...

journal_title：European journal of pharmacology

authors： Ralevic V

更新日期：2000-10-06 00:00:00

abstract：:The coronavirus disease-19 (COVID-19) outbreak that is caused by a highly contagious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a zoonotic pandemic, with approximately 24.5 million positive cases and 8.3 lakhs deaths globally. The lack of effective drugs or vaccine provoked the research fo...

journal_title：European journal of pharmacology

authors： M P,Reddy GJ,Hema K,Dodoala S,Koganti B

更新日期：2021-01-05 00:00:00

abstract：:Exposure of cultured heart muscle cells to noradrenaline led to a decrease in the effects of isoproterenol and prostaglandin E1 on cAMP formation and contraction velocity. However, heterologous desensitization, as measured by prostaglandin E1 stimulation, only occurred at higher noradrenaline concentrations than homol...

journal_title：European journal of pharmacology

authors： Reithmann C,Werdan K

更新日期：1988-09-01 00:00:00