Inhibition of N-methyl-D-aspartate-induced noradrenaline release by alcohols is related to their hydrophobicity.

abstract：:Phasic release of calcium from the sarcoplasmic reticulum occurs in all mammalian cardiac preparations when the intracellular calcium concentration is sufficiently high. The phasic calcium release is often sufficient to trigger electrophysiological responses and aftercontractions. These can be detrimental to normal ca...

journal_title：European journal of pharmacology

authors： Briggs GM,Morgan JP,Gwathmey JK

更新日期：1989-11-07 00:00:00

abstract：:The antimalarial activity of combinations of mefloquine or artesunic acid with ciprofloxacin and other synthetic fluoroquinolone was tested in vitro against Plasmodium falciparum using a strain (BHz26/86) partially resistant to chloroquine and a resistant clone (W2); both are sensitive to mefloquine. Inhibition of par...

journal_title：European journal of pharmacology

authors： Andrade AA,de Pilla Varotti F,de Freitas IO,de Souza MV,Vasconcelos TR,Boechat N,Krettli AU

更新日期：2007-03-08 00:00:00

abstract：:The pharmacological actions of sotalol, (-)-propranolol and prazosin on norepinephrine (NE) concentration and creatine kinase (CK) activity in the coronary sinus blood of the ischemic heart were studied in open-chest dogs. A 60 min occlusion of the left anterior descending coronary artery was followed by a reperfusion...

journal_title：European journal of pharmacology

authors： Lamontagne D,Yamaguchi N,Nadeau R,De Champlain J,Godin D,Campeau N

更新日期：1986-04-09 00:00:00

abstract：:Thiazolidinedione and isoxazolidinedione insulin sensitizers activate peroxisome proliferator-activated receptor gamma (PPAR gamma). Some thiazolidinediones modify ion channels in smooth muscles; however, the mechanism by which their actions occur has not been clarified. We, thus, examined the effects of three thiazol...

journal_title：European journal of pharmacology

authors： Eto K,Ohya Y,Nakamura Y,Abe I,Fujishima M

更新日期：2001-06-29 00:00:00

abstract：:The stimulation of spinal cannabinoid type 2 (CB(2)) receptors is a suitable strategy for the alleviation of experimental pain symptoms. Several reports have described the up-regulation of spinal cannabinoid CB(2) receptors in neuropathic settings together with the analgesic effects derived from their activation. Besi...

journal_title：European journal of pharmacology

authors： Curto-Reyes V,Boto T,Hidalgo A,Menéndez L,Baamonde A

更新日期：2011-10-01 00:00:00

abstract：:Several studies have shown that glycine transporter 1 (GlyT1) inhibitors have anxiolytic actions. There are two types of glycine receptor: the strychnine-sensitive glycine receptor (GlyA) and the strychnine-insensitive glycine receptor (GlyB); however, which receptor is the main contributor to the anxiolytic actions o...

journal_title：European journal of pharmacology

authors： Komatsu H,Furuya Y,Sawada K,Asada T

更新日期：2015-01-05 00:00:00

abstract：:Thoracic preganglionic sympathetic nerve activity, blood pressure, heart rate and femoral arterial conductance were recorded in anaesthetised, paralysed cats. Cumulative dose-response curves were constructed for 8-OH-DPAT, ipsapirone and clonidine. All three drugs caused dose-related falls in blood pressure which were...

journal_title：European journal of pharmacology

authors： Ramage AG,Fozard JR

更新日期：1987-06-19 00:00:00

abstract：:To explore the possibility that raloxifene might influence an adipocyte differentiation and lipogenesis, we studied the effects of raloxifene on the expression of adiponectin and other peroxisome proliferator-activated receptor gamma targeting genes using the 3T3-L1 adipocytes. With standard adipogenic inducers, we ad...

journal_title：European journal of pharmacology

authors： Murase Y,Kobayashi J,Nohara A,Asano A,Yamaaki N,Suzuki K,Sato H,Mabuchi H

更新日期：2006-05-24 00:00:00

abstract：:ATP and other extracellular nucleotides have diverse and potent effects in different organs. Evidence indicates that extracellular nucleotides and nucleosides deliver crucial signals by acting upon a wide variety of purinergic receptors, which include 19 members separated in three families. Purinergic receptors encomp...

journal_title：European journal of pharmacology

authors： Mathieu P

更新日期：2012-12-05 00:00:00

abstract：:The objective of the present studies was to investigate the effect of voluntary ethanol consumption for 21 days on the brain beta-endorphin system of C57BL/6 (alcohol-preferring) and DBA/2 (alcohol-avoiding) strains of mice. As expected, C57BL/6 mice consumed a significantly higher quantity of the 10% ethanol solution...

journal_title：European journal of pharmacology

authors： De Waele JP,Gianoulakis C

更新日期：1994-06-02 00:00:00

abstract：:Corticotropin-releasing factor (CRF) plays a major role at the level of the hypothalamus and pituitary to control the body's response mechanisms to stressful stimuli. The recent discovery of CRF outside the central nervous system suggests that CRF may well play a similar role in peripheral tissues, most likely in a pa...

journal_title：European journal of pharmacology

authors： Schäfer M,Mousa SA,Stein C

更新日期：1997-03-26 00:00:00

abstract：:I.v. administration of McN-2378 appeared to preferentially increase cerebral blood flow as opposed to systemic (femoral) blood flow in two strains of monkeys. This cerebral vasodilation was not affected by theta-adrenergic blockade. In the anesthetized dog, the compound transiently lowered systemic arterial pressure w...

journal_title：European journal of pharmacology

authors： Hageman WE,Pruss TP

更新日期：1975-01-01 00:00:00

abstract：:The antinociceptive effect of nitrous oxide (N(2)O) is dependent on nitric oxide (NO); however, the next step in the pathway activated by NO is undetermined. The present study was conducted to test the hypothesis that a N(2)O action involves sequential activation of NO synthase, soluble guanylyl cyclase and protein ki...

journal_title：European journal of pharmacology

authors： Zhang Y,Quock LP,Chung E,Ohgami Y,Quock RM

更新日期：2011-03-11 00:00:00

abstract：:Adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, adenine and inosine were injected intradermally into the backs of human volunteers. ATP, ADP and AMP evoked weal and flare responses in the skin in a dose dependent manner. The rank order of potency was ATP greater tha...

journal_title：European journal of pharmacology

authors： Coutts AA,Jorizzo JL,Eady RA,Greaves MW,Burnstock G

更新日期：1981-12-17 00:00:00

abstract：:Toll-like receptors (TLRs) play an important role in the recognition of microbial pathogens and induce innate immune responses. The recognition of microbial components by TLRs triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interfero...

journal_title：European journal of pharmacology

authors： Gu GJ,Eom SH,Suh CW,Koh KO,Kim DY,Youn HS

更新日期：2013-12-05 00:00:00

abstract：:The present study was undertaken to compare the properties of the [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) binding site in the dorsal raphe nucleus with the hippocampal 5-HT1A receptor. In both tissues inclusion of 1 mM Mg2+ enhanced specific [3H]8-OH-DPAT binding, while 1 mM GTP decreased radioligand bi...

journal_title：European journal of pharmacology

authors： Johnson RG,Fiorella D,Winter JC,Rabin RA

更新日期：1997-06-18 00:00:00

abstract：:N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methyl-benzamide (RHM-1) and N-[2-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)ethyl]-2-methoxy-5-methylbenzamide (RHM-2), two conformationally flexible benzamide analogues, were radiolabeled with tritium (specific activity=80 Ci/mmol) and the bi...

journal_title：European journal of pharmacology

authors： Xu J,Tu Z,Jones LA,Vangveravong S,Wheeler KT,Mach RH

更新日期：2005-11-21 00:00:00

abstract：:The highly toxic monomer 12-deoxyphorbol 13-palmitate (G) was extracted from the roots of Euphorbia fischeriana. Our experimental data confirmed studies showing that 12-deoxyphorbol 13-palmitate had certain antitumor activities. The MTT method, soft agar experiments, and nude mouse tumor experiments proved that 12-deo...

journal_title：European journal of pharmacology

authors： Xu HY,Chen ZW,Li H,Zhou L,Liu F,Lv YY,Liu JC

更新日期：2013-01-30 00:00:00

abstract：:The effects of local application of a cream containing nitric oxide (NO) donors, S-nitroso-N-acetylpenicillamine (SNAP) or isosorbide dinitrate were studied in a rat model of incision pain. An incision was made in the plantar aspect of a hind paw and the cream was applied inside the surgical wound. SNAP (1-10%) or iso...

journal_title：European journal of pharmacology

authors： Prado WA,Schiavon VF,Cunha FQ

更新日期：2002-04-19 00:00:00

abstract：:In an in vitro model for mitogenic activity in cloned Chinese hamster ovary (CHO) cells expressing rat dopamine D2 or D3 receptors, the EC50D2/EC50D3 ratios for the agonists, apomorphine, (+)-3-hydroxy-N-n-propyl-phenylpiperidine ((+)-3-PPP), quinpirole, R-(+)-7-hydroxy-2-(di-n-propylamino)tetralin (R-(+)-7-OH-DPAT) a...

journal_title：European journal of pharmacology

authors： Svensson K,Carlsson A,Huff RM,Kling-Petersen T,Waters N

更新日期：1994-10-03 00:00:00

abstract：:A high dose of apomorphine, a stimulator of brain dopamine receptors, caused a reduction in total sleep, intermediate sleep and a delayed appearance of paradoxical sleep. With a lower dose, a small and not significant trend toward an increase of paradoxical sleep was observed. Spiroperidol, considered as a specific bl...

journal_title：European journal of pharmacology

authors： Kafi S,Gaillard JM

更新日期：1976-08-01 00:00:00

abstract：:We aimed at investigating the influence of clomipramine and selegiline administered in vivo in mice on lymphocyte subsets in lymphoid organs and SRBC-induced humoral immune response. Balb/c mice were given 7 or 14 oral doses (1 mg/kg) of selegiline or clomipramine. Lymphocyte B and T subsets and splenic regulatory T c...

journal_title：European journal of pharmacology

authors： Szczypka M,Sobieszczańska A,Suszko-Pawłowska A,Lis M

更新日期：2020-11-15 00:00:00

abstract：:Endothelial differentiation gene (EDG) receptors are a new family of eight G protein-coupled receptors for the lysophospholipids lysophosphatitic acid and sphingosine-1-phosphate. In the present experiments, the expression of EDG receptors in rat and human alveolar macrophages was studied by reverse transcription-poly...

journal_title：European journal of pharmacology

authors： Hornuss C,Hammermann R,Fuhrmann M,Juergens UR,Racké K

更新日期：2001-10-19 00:00:00

abstract：:The effect of idebenone on the changes in adenosine and nucleotide metabolism occurring in hippocampal slices after ischemia-like conditions (superfusion with glucose-free Krebs solution gassed with 95% N2-5% CO2) and during reperfusion with normal Krebs solution was investigated by measuring adenosine and inosine out...

journal_title：European journal of pharmacology

authors： Latini S,Pedata F,Pepeu G

更新日期：1993-11-02 00:00:00

abstract：:Chronic administration of amphetamine to cats (twice daily, in doses increasing from 5 to 15 mg/kg over a 10-day period) elicited a number of behaviors e.g., limb flicking, abortive grooming, and excessive head shaking, which were originally proposed as an animal behavioral model for studying the actions of hallucinog...

journal_title：European journal of pharmacology

authors： Trulson ME,Crisp T

更新日期：1984-04-06 00:00:00

abstract：:The chronic constriction injury model is a rat model of neuropathic pain based on a unilateral loose ligation of the sciatic nerve. The aim of the present study was to test its sensitivity to various clinically validated and experimental drugs. Mechanical allodynia and thermal hyperalgesia developed within one week po...

journal_title：European journal of pharmacology

authors： De Vry J,Kuhl E,Franken-Kunkel P,Eckel G

更新日期：2004-05-03 00:00:00

abstract：:(±)-3,4-Methylenedioxymethamphetamine (MDMA) is an illicit drug that evokes transporter-mediated release of serotonin (5-HT) in the brain. 5-HT transporter (SERT) proteins are also expressed in non-neural tissues (e.g., blood), and evidence suggests that MDMA targets platelet SERT to increase plasma 5-HT. Here we test...

journal_title：European journal of pharmacology

authors： Yubero-Lahoz S,Ayestas MA Jr,Blough BE,Partilla JS,Rothman RB,de la Torre R,Baumann MH

更新日期：2012-01-15 00:00:00

abstract：:The present paper describes a theoretical study on the mechanism underlying the reaction of cellular glutathione (GSH) with polyunsaturated fatty acid ozonides. The reaction can be catalyzed by glutathione S-transferases and leads to detoxication of the ozonides. Semi-empirical molecular orbital computer calculations ...

journal_title：European journal of pharmacology

authors： Hempenius RA,de Vries J,Rietjens IM

更新日期：1992-12-01 00:00:00

abstract：:We employed an ex vivo [(3)H]rolipram binding experiment to elucidate the mechanism of emetic activity of phosphodiesterase 4 inhibitors. In Suncus murinus (an insectivore used for evaluation of emesis), emetic potential as well as ability to occupy the high-affinity rolipram binding site in brain membrane fraction in...

journal_title：European journal of pharmacology

authors： Hirose R,Manabe H,Nonaka H,Yanagawa K,Akuta K,Sato S,Ohshima E,Ichimura M

更新日期：2007-11-14 00:00:00

abstract：:The effects of adenyl compounds and some of their analogues were examined on atrial and ventricular muscle of Xenopus laevis. In contrast to all heart muscle preparations studied previously, adenosine produced excitation of the ventricle of Xenopus. 2-Chloroadenosine, ATP, beta, gamma-methylene ATP (APPCP) and alpha, ...

journal_title：European journal of pharmacology

authors： Meghji P,Burnstock G

更新日期：1983-05-06 00:00:00