Abstract:
:Phasic release of calcium from the sarcoplasmic reticulum occurs in all mammalian cardiac preparations when the intracellular calcium concentration is sufficiently high. The phasic calcium release is often sufficient to trigger electrophysiological responses and aftercontractions. These can be detrimental to normal cardiac function. We induced phasic calcium release in ferret papillary muscles loaded with the calcium indicator aequorin. Development of phasic calcium release was associated with an increase in resting and peak [Ca2+]i. Inhibiting sodium channels with yohimbine reduced resting [Ca2+]i and prevented phasic calcium release. We propose a mechanism where by reduced [Na+]i, and the subsequent increased efflux of calcium via sodium/calcium exchange reduced [Ca2+]i.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Briggs GM,Morgan JP,Gwathmey JKdoi
10.1016/0014-2999(89)90551-7subject
Has Abstractpub_date
1989-11-07 00:00:00pages
281-4issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(89)90551-7journal_volume
170pub_type
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