Abstract：
:Changes in autonomic receptor systems (alpha- and beta-adrenoceptors and muscarinic receptors) were compared in the aging and failing human heart. In both settings responsiveness of beta-adrenoceptors and all other receptor systems that evoke their effects via cyclic AMP accumulation was diminished. Muscarinic receptor function, on the other hand, was decreased in the aging, but unchanged in the failing heart; in contrast, G protein-coupled receptor kinase activity was increased in the failing, but unchanged in the aging heart. alpha-Adrenoceptor function was unchanged or slightly decreased in the failing heart. However, nothing is known on alpha-adrenoceptor changes in the aging heart. These results indicate that in the failing human heart all autonomic receptor systems appear to be altered in the direction to attenuate beta-adrenoceptor responses to sympathetic (over)stimulation while in the aging human heart autonomic receptor systems appear to be altered in a direction that protects the heart against too pronounced reduction in beta-adrenoceptor responsiveness.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Brodde OE,Leineweber Kdoi
10.1016/j.ejphar.2004.07.022keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
167-76issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(04)00731-9journal_volume
500pub_type
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journal_title：European journal of pharmacology
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