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7-Nitroindazole reduces nitric oxide concentration in rat hippocampus after transient forebrain ischemia.

Abstract：

:We investigated the effects of 7-nitroindazole, a specific inhibitor of neuronal nitric oxide (NO) synthase, on NO concentration and on blood flow in rat hippocampus after transient forebrain ischemia which was induced by 4-vessel occlusion for 10 min. NO concentration was measured directly by an NO-selective electrode method. Hippocampal blood flow was also estimated by laser Doppler flowmetry. 7-Nitroindazole [0 (vehicle), 12.5, 25, 50 or 100 mg/kg] was administered intraperitoneally 20 min before ischemia. 7-Nitroindazole at any dose used did not affect basal NO levels before ischemia. 7-Nitroindazole (25, 50 and 100 mg/kg) reduced the NO concentration significantly during post-ischemic early reperfusion. Before 10 min of ischemia and during post-ischemic early reperfusion, there were no significant differences in hippocampal basal blood flow and reactive hyperemia between vehicle- and 7-nitroindazole-treated groups. These results demonstrate that the neuronal NO synthase inhibitor, 7-nitroindazole, can effectively inhibit NO synthesis in rat hippocampus during post-ischemic early reperfusion.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Jiang MH,Kaku T,Hada J,Hayashi Y

doi

10.1016/s0014-2999(99)00555-5

keywords:

subject

Has Abstract

pub_date

1999-09-10 00:00:00

pages

117-21

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(99)00555-5

journal_volume

380

pub_type

杂志文章

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