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Effects of inhibitors of prostaglandin synthesis on rebound excitation of guinea-pig small bowel.

Abstract：

:The prostaglandin synthetase inhibitors indomethacin and acetyl salicylic acid did not affect the post-stimulus rebound excitation of guinea-pig duodenal and jejunal circular muscle with transmural electrical stimulation at 1 min intervals. In the absence of any drug, sequential time-dependent changes in amplitude of the rebound contractions were: (1) progressive increase during first 10 min, (2) a plateau at 30 min, (3) progressive decline to almost no response over 3 h. The results indicate that, in the circular muscle layer, prostaglandin synthesis is not required for production of the rebound response following electrical stimulation of inhibitory neurons.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Mitchell GW,Wood JD

doi

10.1016/0014-2999(76)90354-x

subject

Has Abstract

pub_date

1976-11-01 00:00:00

pages

63-6

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(76)90354-X

journal_volume

40

pub_type

杂志文章

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