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Antagonism by neuroleptics of serotonin 5-HT1A and 5-HT2 receptors of normal human brain in vitro.

Abstract：

:Using radioligand binding techniques and human frontal cortex, we determined the equilibrium dissociation constants (KDs) of 17 neuroleptics at the serotonin 5-HT1A and serotonin 5-HT2 receptors with [3H]WB4101 and [3H]ketanserin, respectively. At the serotonin 5-HT1A receptor, the most and least potent neuroleptics were chlorprothixene (KD = 230 nM) and fluphenazine (KD = 40 microM), respectively. At the serotonin 5-HT2 receptor, the most and least potent neuroleptics were spiperone (KD = 0.38 nM) and molindone, (KD = 5 microM), respectively.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Wander TJ,Nelson A,Okazaki H,Richelson E

doi

10.1016/0014-2999(87)90544-9

subject

Has Abstract

pub_date

1987-11-10 00:00:00

pages

279-82

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(87)90544-9

journal_volume

143

pub_type

杂志文章

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