Abstract:
:It has been reported that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) can modulate opioid tolerance via its action on learning and memory. In this study, we examine if CaMKII can directly affect opioid tolerance. We found that spinal CaMKII activity was increased in rats tolerant to morphine. In these rats, acute spinal administration of 2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine) (KN93), a CaMKII inhibitor, was able to reverse the already-established antinociceptive tolerance. These results suggest that CaMKII may directly promote opioid tolerance.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Wang ZJ,Tang L,Xin Ldoi
10.1016/s0014-2999(03)01484-5keywords:
subject
Has Abstractpub_date
2003-03-28 00:00:00pages
199-200issue
1-2eissn
0014-2999issn
1879-0712pii
S0014299903014845journal_volume
465pub_type
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journal_title:European journal of pharmacology
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