Abstract:
:To assess the role of the alpha 7 neuronal nicotinic acetylcholine receptor in the discriminative stimulus properties of (-)-nicotine, this study investigated the ability of the alpha 7 receptor antagonist methyllycaconitine to modulate the nicotine cue. In rats trained to discriminate (-)-nicotine from saline, intraperitoneal injections of methyllycaconitine neither induced nor blocked the nicotine cue. Intracerebroventricular administration of methyllycaconitine, neither potentiated nor blocked the effect of (-)-nicotine. On the other hand, intracerebroventricular injections of mecamylamine blocked the nicotine cue. The available evidence indicate that the nicotinic acetylcholine receptors in the brain blocked by methyllycaconitine, those presumably containing alpha 7 subunits, do not participate in the expression of the discriminative stimulus properties of (-)-nicotine.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Brioni JD,Kim DJ,O'Neill ABdoi
10.1016/0014-2999(96)00010-6subject
Has Abstractpub_date
1996-04-22 00:00:00pages
1-5issue
1-3eissn
0014-2999issn
1879-0712pii
0014-2999(96)00010-6journal_volume
301pub_type
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journal_title:European journal of pharmacology
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