Abstract:
:A significant stimulatory action of PGE1 on adenylate cyclase of the particulate membrane preparation of rat heart was observed at 1 X 10(-4) M. PGE1 caused a positive inotropic effect on isolated spontaneously beating rat atria 1 X (10(-5) M, and an increase in atrial cyclic AMP level at 1 X 10(-6) M. PGE2 stimulated the atrial but not the whole heart particulate adenylate cyclase. PGF 2alpha had no effect on these enzyme preparations. Our results suggest that: (i) The inotropic response of isolated spontaneously beating rat atria to PGE1 may be connected with an increase in cyclic AMP level; (ii) the effect of prostaglandins on heart in vivo must be indirect, because the concentrations needed to stimulate isolated atria and particulate adenylate cyclase were high, compared with the doses effective in vivo.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Kangasaho M,Metsä-Ketelä T,Vapaatalo Hdoi
10.1016/0014-2999(78)90025-0subject
Has Abstractpub_date
1978-11-01 00:00:00pages
93-8issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(78)90025-0journal_volume
52pub_type
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