Amelioration of brain damage after focal ischemia in the rat by a novel inhibitor of lipid peroxidation.

abstract：:In the sheep cerebral vasculature 5-hydroxytryptamine (5-HT) caused a contraction of which ketanserin was found to be an effective antagonist (Basilar artery, pA2 = 9.33 +/- 0.16; middle cerebral artery, pA2 = 9.19 +/- 0.16; pial artery, pA2 = 9.47 +/- 0.12). Sumatriptan (GR 43175), a selective 5-HT1-like receptor ago...

journal_title：European journal of pharmacology

authors： Gaw AJ,Wadsworth RM,Humphrey PP

更新日期：1990-04-10 00:00:00

abstract：:Diazepam (10(-5)-3 X 10(-4) M) selectively enhanced the negative inotropic responses of guinea-pig atria and the relaxation of guinea-pig taenia coli caused by adenosine and ATP. In the atria, the effect of 2-chloroadenosine, a stable analog of adenosine, was not affected by diazepam. Segments of guinea-pig atria or t...

journal_title：European journal of pharmacology

authors： Moritoki H,Fukuda H,Kotani M,Ueyama T,Ishida Y,Takei M

更新日期：1985-07-11 00:00:00

abstract：:The specificity of action of extrinsic acetylcholine on extrajunctional and junctional receptors in the chick biventer cervicis muscle was studied by determining its ability to protect the responses evoked by acetylcholine and by tetanic nerve stimulation from the blockade by alpha-bungarotoxin, an irreversible bindin...

journal_title：European journal of pharmacology

authors： Chang CC,Su MJ

更新日期：1975-09-01 00:00:00

abstract：:The effects of treatment with anxiogenic or anxiolytic agents and exposure to acute restraint stress on emotional behavior in mice were examined using an automatic hole-board apparatus. Changes in the emotional state of mice were evaluated in terms of changes in exploratory activity, i.e., total locomotor activity, nu...

journal_title：European journal of pharmacology

authors： Takeda H,Tsuji M,Matsumiya T

更新日期：1998-05-29 00:00:00

abstract：:The endogenous release of adenosine 5'-triphosphate (ATP) from strips of guinea-pig gallbladder during transmural stimulation (TS) was measured with a firefly luciferine-luciferase reaction. TS (15V, 1 ms, 0.5-5 Hz, for 1 min) caused a rapid and marked increase of ATP release in a frequency-dependent manner. Both ATP ...

journal_title：European journal of pharmacology

authors： Takahashi T,Kusunoki M,Ishikawa Y,Kantoh M,Yamamura T,Utsunomiya J

更新日期：1987-01-28 00:00:00

abstract：:Substance P (SP) caused an immediate and vigorous contraction of the longitudinal smooth muscle layer of the guinea-pig ileum. The contractile response to SP, unlike that to acetylcholine or histamine was not maintained but faded to baseline levels in about 6 min. When 0.3-1.0 nM SP was added the fading time was short...

journal_title：European journal of pharmacology

authors： Huidobro-Toro JP,Chelala CA,Bahouth S,Nodar R,Musacchio JM

更新日期：1982-06-16 00:00:00

abstract：:Angiogenesis is critical for re-establishing blood supply to the ischemic myocardium after acute myocardial infarction (AMI). This study aimed to investigate the effects of morroniside on angiogenesis after AMI and explored associated proangiogenic mechanisms. A rat model of AMI was established by ligation of the left...

journal_title：European journal of pharmacology

authors： Liu T,Sun F,Cui J,Zheng S,Li Z,Guo D,Tian X,Zhu Z,Zheng W,Wang Y,Wang W

更新日期：2020-04-05 00:00:00

abstract：:Acute administration of fluoxetine (1, 10 and 20 mg/kg i.p.) increased extracellular levels of serotonin (5-hydroxytryptamine, 5-HT) in the frontal cortex, ventral hippocampus and raphe nuclei as measured by in vivo microdialysis in anaesthetized rats. In the frontal cortex, fluoxetine showed a marked dose-response ef...

journal_title：European journal of pharmacology

authors： Malagié I,Trillat AC,Jacquot C,Gardier AM

更新日期：1995-11-14 00:00:00

abstract：:Three agents with K+ channel blocking activity, procaine, 4-aminopyridine (4-AP) and tetraethylammonium (TEA), were tested for inhibition of vasorelaxation and 86Rb+ efflux induced by cromakalim (BRL 34915), pinacidil and nicorandil in rabbit isolated mesenteric artery. The potency order for inhibition of vasorelaxati...

journal_title：European journal of pharmacology

authors： Wilson C,Coldwell MC,Howlett DR,Cooper SM,Hamilton TC

更新日期：1988-08-02 00:00:00

abstract：:In the attempt to find a pharmacological treatment for the spasm of the internal anal sphincter, usually associated with anal fissures, the activity of caerulein on human internal and sphincter was investigated in vitro and in vivo. In the isolated distal part of the internal and sphincter, caerulein (0.61 microM) dep...

journal_title：European journal of pharmacology

authors： Carpenedo F,Infantino A,Floreani M,Dodi G

更新日期：1983-02-18 00:00:00

abstract：:Statins have been demonstrated to elicit a broad range of cellular events resulting in an attenuation of the inflammatory response and enhanced protection to the components of the vessel wall. The present study was designed to examine the effect of pitavastatin on pathways associated with the proinflammatory gene, ear...

journal_title：European journal of pharmacology

authors： Lamon BD,Summers BD,Gotto AM Jr,Hajjar DP

更新日期：2009-03-15 00:00:00

abstract：:3H-Glycine was released by 50 mM K+ in a calcium-dependent manner from rat substantia nigra slices. This release was abolished by GABA (0.1-1 mM) and muscimol (0.1 mM). Taurine and beta-alanine were without effect on evoked 3H-glycine release. The effect of GABA (0.5 mM) was reversed picrotoxin (50 micro M). These res...

journal_title：European journal of pharmacology

authors： Kerwin R,Pycock C

更新日期：1980-06-13 00:00:00

abstract：:The effects of intra- and extraluminal capsaicin administration were evaluated in isolated perfused rat mesenteric bed. Capsaicin (10 nM-1 microM) produced a potent concentration-dependent relaxation of the tonic vasoconstriction induced by norepinephrine (1 microM) but not by high-K+ (60 mM). The capsaicin-induced re...

journal_title：European journal of pharmacology

authors： Manzini S,Perretti F

更新日期：1988-03-29 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), a main flavanol of green tea, potently suppressed the urokinase-type plasminogen activator (uPA) expression in human fibrosarcoma HT 1080 cells. EGCG induced not only the suppression of the uPA promoter activity but also the destabilization of uPA mRNA. EGCG inhibited the phospho...

journal_title：European journal of pharmacology

authors： Kim MH,Jung MA,Hwang YS,Jeong M,Kim SM,Ahn SJ,Shin BA,Ahn BW,Jung YD

更新日期：2004-03-08 00:00:00

abstract：:Dopamine agents (saline in control groups) were coadministered with indomethacin by either single or repeated application. The ulcerogenic effect (erosions and/or ulcers) of repeated given indomethacin on gastric mucosa differed clearly from that on intestinal mucosa. The effect on intestinal mucosa was markedly great...

journal_title：European journal of pharmacology

authors： Sikirić P,Rotkvić I,Mise S,Krizanac S,Gjuris V,Jukić J,Suchanek E,Petek M,Udovicić I,Kalogjera L

更新日期：1988-12-06 00:00:00

abstract：:In the rat substantia nigra Type II benzodiazepine recognition sites (measured as the portion of [3H]flunitrazepam binding which remain after the addition of 2 X 10(-7) M Cl 218872) represent 50% of the total benzodiazepine recognition sites. The density of Type II sites was increased by 35% following the degeneration...

journal_title：European journal of pharmacology

authors： Porceddu ML,Corda MG,Sanna E,Biggio G

更新日期：1985-06-07 00:00:00

abstract：:Gaboxadol (THIP; 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) is an agonist at GABA(A) receptors. THIP concentrations (0.01-50 mM) were applied rapidly to Sf9 cells expressing the human alpha(1)beta(2)gamma(2S) GABA(A) receptors. The EC(50) values for the peak current in THIP alone or THIP plus 1 microM diazepam we...

journal_title：European journal of pharmacology

authors： Smith M,Lindquist CE,Birnir B

更新日期：2003-09-30 00:00:00

abstract：:A brain slice preparation was used to examine the effects of galanin on the spontaneous firing rate of locus coeruleus noradrenergic neurons. Galanin (10(-9)-10(-7) M), added to the bath, inhibited the firing of 14 out of 19 neurons in a concentration-dependent manner. The observed effect was quite variable, ranging f...

journal_title：European journal of pharmacology

authors： Seutin V,Verbanck P,Massotte L,Dresse A

更新日期：1989-05-19 00:00:00

abstract：:Disulfiram (700 mg/kg, p.o.) significantly increased the brain levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in rats. Ethanol (1 g/kg and 2 x 1.5 g/kg, i.p.) did not affect the 5-HT level, but at the higher dose it significantly increased the 5-HIAA level. When disulfiram was given in combination ...

journal_title：European journal of pharmacology

authors： Fukumori R,Minegishi A,Satoh T,Kitagawa H,Yanaura S

更新日期：1980-01-25 00:00:00

abstract：:We investigated whether estrogen protects the ischemic myocardium in oophorectomized female rabbits fed with a cholesterol-enriched diet, whether the addition of a progestin compound attenuates the beneficial effect of estrogen and whether raloxifene also limits myocardial necrosis. We treated 32 female oophorectomize...

journal_title：European journal of pharmacology

authors： Sbarouni E,Iliodromitis EK,Bofilis E,Kyriakides ZS,Kremastinos DT

更新日期：2003-04-25 00:00:00

abstract：:Studies have shown a cardioprotective role of thyroid hormones (THs) in cardiac remodeling after acute myocardial infarction (MI). However, there is no data in the literature examining the influence of TH administration on the aortic tissue in an animal model of MI. This study aimed to evaluate the effects of thyroid ...

journal_title：European journal of pharmacology

authors： Ortiz VD,de Castro AL,Campos C,Fernandes RO,Bonetto JHP,Siqueira R,Conzatti A,Fernandes TRG,Belló-Klein A,Araujo ASR

更新日期：2016-11-15 00:00:00

abstract：:The effects of famotidine on the cardiac repolarization process were assessed using four different levels of test systems described in the draft stage guideline ICH S7B. A supratherapeutic concentration of famotidine (10(-5) M), which is >8 times higher than C(max) obtained after its therapeutic dose, neither inhibite...

journal_title：European journal of pharmacology

authors： Sugiyama A,Satoh Y,Takahara A,Nakamura Y,Shimizu-Sasamata M,Sato S,Miyata K,Hashimoto K

更新日期：2003-04-11 00:00:00

abstract：:Anorexia and muscle wasting are frequently observed in cancer patients and influence their clinical outcome. The better understanding of the mechanisms underlying behavioral changes and altered metabolism yielded to the development of specialized nutritional support, which enhances utilization of provided calories and...

journal_title：European journal of pharmacology

authors： Laviano A,Seelaender M,Sanchez-Lara K,Gioulbasanis I,Molfino A,Rossi Fanelli F

更新日期：2011-09-01 00:00:00

abstract：:Treatment of rat reticulocytes with tetradecanoyl phorbol acetate (TPA), a tumor-promoting phorbol ester which activates protein kinase C, resulted in an about 50% decrease in the stimulation of adenylate cyclase activity by a subsequent challenge with a beta-adrenoceptor agonist. This phenomenon mimics agonist-induce...

journal_title：European journal of pharmacology

authors： Yamashita A,Kurokawa T,Une Y,Ishibashi S

更新日期：1988-07-07 00:00:00

abstract：:Major depression is a prevalent and debilitating disorder and a substantial proportion of patients fail to reach remission following standard antidepressant pharmacological treatment. Limited efficacy with currently available antidepressant drugs highlights the need to develop more effective medications for treatment-...

journal_title：European journal of pharmacology

authors： Caldarone BJ,Zachariou V,King SL

更新日期：2015-04-15 00:00:00

abstract：:Cross-tolerance to the respiratory depression induced by i.c.v. [D-Ala2,D-Leu5]enkephalin (DADLE) and by s.c., i.c.v. and i.v. morphine was studied in anesthetized rats that had been rendered tolerant to s.c. sufentanil (4 micrograms/h per 7 days). Tolerance induced by i.c.v. sufentanil was also compared during withdr...

journal_title：European journal of pharmacology

authors： Ayesta FJ,Flórez J

更新日期：1990-01-03 00:00:00

abstract：:We investigated the therapeutic effects of OK432 (picibanil; CAS39325-1-4), an immunomodulator that is derived from the Su strain of Streptococcus pyogenes. This agent was administered alone or combined with human interferon-alpha in a murine model of insulin-dependent diabetes mellitus. Interferon-alpha inhibits vira...

journal_title：European journal of pharmacology

authors： Kanda T,Kogure S,Nara M,Tsukui S,Utsugi T,Tomono S,Kawazu S,Nagai R,Kobayashi I

更新日期：1998-01-26 00:00:00

abstract：:Achondroplasia, results from a mutation in the FGF receptor type 3, leading to receptor hyperactivation and subsequent amplification of FGF receptor type 3 signals. We have tested the ability of pyridoxal-5'-phosphate-6-azophenyl-2', 4'-disulfonate (PPADS) to decrease the overactivation and signalling of FGF receptor ...

journal_title：European journal of pharmacology

authors： Guzmán-Aránguez A,Crooke A,Yayon A,Pintor J

更新日期：2008-04-14 00:00:00

abstract：:In this study we compared characteristics of (-)-[3H]dihydroalprenolol ([3H]DHA) binding sites in crude membrane preparations of human peripheral blood lymphocytes with those of intact, viable cells. A valid determination of specific beta-adrenergic receptor binding in both preparations was obtained by defining non-sp...

journal_title：European journal of pharmacology

authors： Meurs H,van den Bogaard W,Kauffman HF,Bruynzeel PL

更新日期：1982-11-19 00:00:00

abstract：:The effects of riluzole, an anticonvulsant and neuroprotective compound, on excitatory amino acid-evoked currents were studied in Xenopus laevis oocytes injected with mRNA from rat whole brain or cortex. Responses to kainic acid were blocked by riluzole (IC50 = 167 microM) as well as by the quinoxalinedione antagonist...

journal_title：European journal of pharmacology

authors： Debono MW,Le Guern J,Canton T,Doble A,Pradier L

更新日期：1993-04-28 00:00:00