Effect of rosuvastatin treatment on plasma visfatin levels in patients with primary hyperlipidemia.

abstract：:Rolipram was characterized for its emetic, behavioral, cardiovascular and pulmonary activities in dogs, to assess its systemic pharmacology and potential bronchodilatory selectivity. At doses > or = 0.1 mg/kg i.v., rolipram induced emesis, anxiety, and stepping behaviors in conscious dogs, and increased heart rate and...

journal_title：European journal of pharmacology

authors： Heaslip RJ,Evans DY

更新日期：1995-11-24 00:00:00

abstract：:Acute benzodiazepine administration has been reported to antagonize the effect of cholecystokinin both in the periphery and in the central nervous system. A two-week treatment with either diazepam (5 mg/kg per day) or flurazepam (15 mg/kg per day) markedly reduced the excitatory effect of microiontophoretically applie...

journal_title：European journal of pharmacology

authors： Bouthillier A,De Montigny C

更新日期：1988-06-22 00:00:00

abstract：:Theophylline (0.1, 0.3 mM) produced a positive inotropism which was maximum by 15 min but was partially or completely absent by 45 min. The mechanism for this response was investigated using post-rest potentiation and positive staircase, phenomenon associated with the sarcoplasmic reticulum and sarcolemma, respectivel...

journal_title：European journal of pharmacology

authors： Zavecz JH

更新日期：1989-01-24 00:00:00

abstract：:Isolated and purified leucocytosis promoting factor (LPF), alternatively described as pertussis toxin, reduced the hypotension after beta 2-adrenoceptor stimulation with salbutamol as well as the negative chronotropic activity induced by the muscarinic receptor stimulant arecoline 4 days after its injection into rats....

journal_title：European journal of pharmacology

authors： De Wildt DJ,De Jong Y,Nijkamp FP,Kreeftenberg JG

更新日期：1986-08-15 00:00:00

abstract：:The effects of substitutions in the xanthine nucleus on tracheal relaxant activity, atrium chronotropic activity, adenosine A1 affinity, and inhibitory activities on cyclic AMP-phosphodiesterase isoenzymes in guinea pigs were studied. Substitution with a long alkyl chain at the N1-position of xanthine nucleus increase...

journal_title：European journal of pharmacology

authors： Miyamoto K,Kurita M,Ohmae S,Sakai R,Sanae F,Takagi K

更新日期：1994-05-17 00:00:00

abstract：:This review focuses on alpha(1)-adrenoceptor phosphorylation and function. Most of what is currently known is based on studies on the hamster alpha(1B)-adrenoceptor. It is known that agonist stimulation leads to homologous desensitization of these receptors and current evidence indicates that such decrease in receptor...

journal_title：European journal of pharmacology

authors： García-Sáinz JA,Vázquez-Prado J,del Carmen Medina L

更新日期：2000-02-11 00:00:00

abstract：:Prostate cancer is one of the most severe malignancies in men, and many genes and non-coding RNAs, included microRNAs (miRs), have been demonstrated to regulate prostate cancer progression. In the present study, we investigated the role of miR-671 in prostate cancer cell proliferation. We found that miR-671 was signif...

journal_title：European journal of pharmacology

authors： Yu Y,Wang Z,Sun D,Zhou X,Wei X,Hou W,Ding Y,Ma Y,Hou Y

更新日期：2018-03-15 00:00:00

abstract：:Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells...

journal_title：European journal of pharmacology

authors： Jean YH,Chen WF,Duh CY,Huang SY,Hsu CH,Lin CS,Sung CS,Chen IM,Wen ZH

更新日期：2008-01-14 00:00:00

abstract：:In this study we investigated if sodium nitroprusside (NaNP), a vasodilator with direct action on smooth muscle, would have any effect on calcium kinetics in blood vessels. The effect of NaNP, in 0.1-10 micrometer concentration, was studied in vitro on the uptake of 45Ca with the lanthanum method and on the efflux of ...

journal_title：European journal of pharmacology

authors： Zsotér TT,Henein NF,Wolchinsky C

更新日期：1977-09-01 00:00:00

abstract：:This work investigates the actions of LASSBio-1289, (E)-N-methyl-N'-(thiophen-3-methylene)benzo[d][1,3]dioxole-5-carbohydrazide, on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats. Two weeks following the MCT injection, LASSBio-1289 (50 or 75mg/kg, p.o.) or vehicle was administrated once dail...

journal_title：European journal of pharmacology

authors： Pereira SL,Kummerle AE,Fraga CA,Barreiro EJ,Rocha Nde N,Ferraz EB,do Nascimento JH,Sudo RT,Zapata-Sudo G

更新日期：2013-02-28 00:00:00

abstract：:Cancer remains a major public health problem worldwide and was responsible for 9.6 million deaths in 2018. Oncologic treatments such as doxorubicin (Dox) and trastuzumab (Trz) are chemotherapeutic drugs used to treat several types of cancer, including solid and non-solid malignancies. Although these drugs have a signi...

journal_title：European journal of pharmacology

authors： Prathumsap N,Shinlapawittayatorn K,Chattipakorn SC,Chattipakorn N

更新日期：2020-01-05 00:00:00

abstract：:Many atypical antipsychotic drugs, such as olanzapine, induce significant weight gain. However, ziprasidone produces minimal weight gain, the mechanism of which remains unclear. The aim of the present study was to investigate whether ziprasidone would reduce the acute effect of olanzapine on feeding behaviour. The res...

journal_title：European journal of pharmacology

authors： Kirk SL,Neill JC,Jones DN,Reynolds GP

更新日期：2004-11-28 00:00:00

abstract：:We examined the feasibility of coupling the 5-HT(6) receptor to a Ca(2+) signaling read-out using a chimeric G-protein, comprising of G(alphaq) with the C-terminal five amino acids from G(alphas), to facilitate assays on the fluorometric imaging plate reader (FLIPR). Using a transient transfection assay in human embry...

journal_title：European journal of pharmacology

authors： Zhang JY,Nawoschik S,Kowal D,Smith D,Spangler T,Ochalski R,Schechter L,Dunlop J

更新日期：2003-07-04 00:00:00

abstract：:Nafazatrom, an inhibitor of arachidonate metabolism by the lipoxygenase enzymes, decreases basal prolactin and growth hormone release in a concentration-dependent manner without significantly affecting the synthesis of either hormone. It is required that nafazatrom be incubated with pituitary cells for approximately 2...

journal_title：European journal of pharmacology

authors： Judd AM,Login IS,Ehreth JT,MacLeod RM

更新日期：1986-09-09 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognitive deficit. The observed amnesia in the early stages of AD is suggested to be a retrieval problem, rather than encoding and consolidation deficit. According to the cholinergic hypothesis of AD, scopolamine i...

journal_title：European journal of pharmacology

authors： Moosavi M,SoukhakLari R,Moezi L,Pirsalami F

更新日期：2018-01-15 00:00:00

abstract：:Experiments were conducted to explore the effects of Neuropeptide FF acting at spinal and supraspinal sites in models of chronic inflammatory or neuropathic pain and of acute pain. Neuropeptide FF was administered intrathecally (i.t.; 10.0, 25.0 and 50.0 nmol) or intracerebroventricularly (i.c.v.; 10.0, 12.5 and 15.0 ...

journal_title：European journal of pharmacology

authors： Altier N,Dray A,Ménard D,Henry JL

更新日期：2000-11-03 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, is found in the central nervous system as well as in the heart. CGRP shows high sequence homology with amylin, salmon calcitonin, and adrenomedullin. This study aimed to investigate the effect of CGRP on atrial hemodynamics and atrial natriuretic pe...

journal_title：European journal of pharmacology

authors： Piao FL,Cao C,Han JH,Kim SZ,Kim SH

更新日期：2004-01-12 00:00:00

abstract：:Rat and human alpha- and beta-calcitonin gene-related peptide (CGRP), in the concentration range 1-100 nM, produced sustained relaxations of longitudinal muscle from the rat fundus and guinea pig gastric corpus. The peptides were equipotent and equally effective. Tetrodotoxin, adrenoceptor and purine receptor antagoni...

journal_title：European journal of pharmacology

authors： Katsoulis S,Conlon JM

更新日期：1989-03-14 00:00:00

abstract：:The alpha 2-adrenoceptor antagonist, yohimbine, has been reported to protect hypoxic myocardium. Yohimbine has several other activities, including 5-HT receptor antagonism, at the concentrations at which protection was found. Therefore we designed a study to determine if yohimbine was protecting ischemic myocardium vi...

journal_title：European journal of pharmacology

authors： Sargent CA,Dzwonczyk S,Grover GJ

更新日期：1994-08-11 00:00:00

abstract：:The inhibition by various serotonin agonists and antagonists of the binding of 3 nM 3H-d-LSD, 1.7 nM 3H-serotonin and 0.22 nM 3H-spiperone to homogenates of calf hippocampus and frontal cortex was studied. The 50% inhibitory concentration (IC50) for these drugs versus 3H-d-LSD binding had similar values to and correla...

journal_title：European journal of pharmacology

authors： Seeman P,Westman K,Coscina D,Warsh JJ

更新日期：1980-08-29 00:00:00

abstract：:The effect of estrogen on neointimal formation in injured rat arteries has been reported to be a sexual dimorphic effect. Recently, it has been reported that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) exhibit vasoprotective effects, which are independent of their cholesterol-lowerin...

journal_title：European journal of pharmacology

authors： Kurumazuka D,Mori T,Matsumoto N,Shirakawa H,Kimura S,Nakano D,Hayashi T,Kitaura Y,Matsumura Y

更新日期：2006-12-28 00:00:00

abstract：:Terfenadine and astemizole rarely cause cardiac arrhythmias by suppressing the cardiac rapid delayed rectifier K+ channel encoded by the human ether-a-go-go-related gene (HERG). Epinastine, however, has not been reported to have the adverse effect. We have therefore compared the effects of epinastine, terfenadine and ...

journal_title：European journal of pharmacology

authors： Chachin M,Katayama Y,Yamada M,Horio Y,Ohmura T,Kitagawa H,Uchida S,Kurachi Y

更新日期：1999-06-25 00:00:00

abstract：:Ohmefentanyl has been shown to be 6300 times more potent than morphine for analgesia. The receptor binding characteristics and distribution of [3H]ohmefentanyl in rat brain sections are presented. [3H]Ohmefentanyl bound with high affinity to opioid receptors in a saturable manner (Kd = 0.95 +/- 0.08 nM, Bmax = 337 +/-...

journal_title：European journal of pharmacology

authors： Wang H,Pélaprat D,Roques BP,Vanhove A,Chi ZQ,Rostène W

更新日期：1991-02-14 00:00:00

abstract：:The main purpose of this study was to compare in vitro pharmacological properties of human αCGRP (CGRP) and a recently discovered metabolically stable CGRP analogue, SAX, in isolated rat and human artery segments. In rat, CGRP and SAX induced similar vasodilatory responses in isolated mesenteric artery with the potenc...

journal_title：European journal of pharmacology

authors： Sheykhzade M,Abdolalizadeh B,Koole C,Pickering DS,Dreisig K,Johansson SE,Abboud BK,Dreier R,Berg JO,Jeppesen JL,Sexton PM,Edvinsson L,Wootten D,Sams A

更新日期：2018-06-15 00:00:00

abstract：:Activated factor X (FXa) is an important player in the coagulation cascade responsible for thrombin generation, which is activated during atrial fibrillation. Increasing evidence suggests that FXa influences cell signalling in various cell types by activating protease-activated receptors (PARs). It is so far not known...

journal_title：European journal of pharmacology

authors： Bukowska A,Zacharias I,Weinert S,Skopp K,Hartmann C,Huth C,Goette A

更新日期：2013-10-15 00:00:00

abstract：:It has been well documented that nordihydroguaiaretic acid (NDGA), a phenolic lignan isolated from the creosote bush, Larrea tridentate, has anti-cancer activity in vitro and in vivo. Several mechanisms have been identified that could contribute to these actions, as NDGA directly inhibits metabolic enzymes and recepto...

journal_title：European journal of pharmacology

authors： Li F,Pham JD,Anderson MO,Youngren JF

更新日期：2009-08-15 00:00:00

abstract：:Inhibitory effects of the saponin fraction and its principal constituents, escins Ia, Ib, IIa, and IIb, from horse chestnuts on gastric emptying were investigated in mice loaded with a non-nutrient or nutrient meal. The saponin fraction and escins Ia-IIb inhibited gastric emptying of a 1.5% carboxymethyl cellulose sod...

journal_title：European journal of pharmacology

authors： Matsuda H,Li Y,Murakami T,Yamahara J,Yoshikawa M

更新日期：1999-03-05 00:00:00

abstract：:The occurrence and characteristics of binding sites specific for gamma-aminobutyric acid (GABA) and muscimol in the rat stomach were examined by biochemical and autoradiographic techniques, and the effects of GABAergic model compounds on gastric ulceration induced by chemical irritation was studied in intact and unila...

journal_title：European journal of pharmacology

authors： Erdö SL,Ezer E,Matuz J,Wolff JR,Amenta F

更新日期：1989-06-08 00:00:00

abstract：:The effects of alpha 1-adrenergic stimulation on intracellular pH (pHi) and Ca2+ concentration ([Ca2+]i) were investigated in isolated rat cardiomyocytes with fluorescence dyes, BCECF and fura-2, respectively. In the presence of 5 or 25 mM HCO3- norepinephrine (NE) increased pHi in a dose-dependent manner. Intracellul...

journal_title：European journal of pharmacology

authors： Iwakura K,Hori M,Watanabe Y,Kitabatake A,Cragoe EJ Jr,Yoshida H,Kamada T

更新日期：1990-09-04 00:00:00

abstract：:Several effects of bacterial endotoxins involve an opioid pathway and neuropeptide FF is an endogenous peptide known to modulate opioid activity, mainly in the central nervous system. The aim of this study was to investigate in rats the role of central neuropeptide FF receptors in intestinal motor disturbances and bod...

journal_title：European journal of pharmacology

authors： Million M,Fioramonti J,Zajac JM,Buéno L

更新日期：1997-09-03 00:00:00