Opposing roles for D-1 and D-2 dopamine receptors in regulating the excitability of growth hormone-producing cells in the snail Lymnaea stagnalis.

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor dysfunctions resulting from the loss of upper (UMNs) and lower (LMNs) motor neurons. While ALS symptoms are coincidental with pathological changes in LMNs and UMNs, the causal relationship between the two is unclear....

journal_title：European journal of pharmacology

authors： Nakagawa Y,Yamada S

更新日期：2021-02-05 00:00:00

abstract：:Phorbol esters reduce depolarization-evoked Ca2+ influx in adrenal chromaffin cells, suggesting that voltage-sensitive Ca2+ channels (VSCCs) are inhibited by protein kinase C-mediated phosphorylation. We now address the possibility that L- and P/Q-type Ca2+ channel subtypes might be differentially involved in phorbol ...

journal_title：European journal of pharmacology

authors： Sena CM,Santos RM,Boarder MR,Rosário LM

更新日期：1999-02-05 00:00:00

abstract：:In adult male rats, injection of TRH into a lateral ventricle of the brain 5 min prior to pentobarbital (PB) administration caused a significant dose-related inhibition of prolactin (PRL) release, in doses ranging from 500 to 5 ng. Among 8 TRH analogues devoid of thyrotropin-releasing activity, 6 were found to signifi...

journal_title：European journal of pharmacology

authors： Taché Y,Ruisseau PD,Ducharme JR,Collu R

更新日期：1977-10-15 00:00:00

abstract：:Increased expressions of cyclooxygenase-2 (COX-2) and its downstream metabolite, prostaglandin E2 (PGE2), are well documented events in the development of colorectal cancer. Interestingly, PGE2 itself can induce the expression of COX-2 thereby creating the potential for positive feedback. Although evidence for such a ...

journal_title：European journal of pharmacology

authors： Yoshida K,Fujino H,Otake S,Seira N,Regan JW,Murayama T

更新日期：2013-10-15 00:00:00

abstract：:Clonidine and methysergide constrict the rabbit auricular artery by activating smooth muscle alpha-adrenoceptors. Clonidine inhibits and methysergide enhances responses to stimulation of the sympathetic nerves. Both drugs sensitise the artery to a variety of vasoconstrictor stimuli, although not to potassium chloride....

journal_title：European journal of pharmacology

authors： Fozard JR

更新日期：1976-03-01 00:00:00

abstract：:Sulfonylurea drugs exert their insulinotropic action by inhibiting ATP-sensitive potassium channels in the pancreas. However, these channels are also expressed in myocardial and vascular smooth muscle, implicating possible detrimental cardiovascular effects. Aim of the present study was to investigate the inhibitory p...

journal_title：European journal of pharmacology

authors： Engbersen R,Masereeuw R,van Gestel MA,Siero HL,Moons MM,Smits P,Russel FG

更新日期：2012-04-15 00:00:00

abstract：:Diabetes mellitus is associated with an increased risk of cardiovascular disease. Endothelial dysfunction (i.e. decreased endothelium-dependent vasorelaxation) plays a key role in the pathogenesis of diabetic vascular disease. The present study was undertaken to determine whether diabetes induced by streptozotocin alt...

journal_title：European journal of pharmacology

authors： Fatehi-Hassanabad Z,Imen-Shahidi M,Fatehi M,Farrokhfall K,Parsaeei H

更新日期：2006-03-27 00:00:00

abstract：:Some studies have suggested that drug tolerance observed following repeated benzodiazepine exposure may be associated with the development of a subsensitivity to gamma-aminobutyric acid (GABA) in dorsal raphe and hippocampal neurons. In other areas such as the substantia nigra such subsensitivity has not been found. T...

journal_title：European journal of pharmacology

authors： Hutchinson MA,Smith PF,Darlington CL

更新日期：1996-04-22 00:00:00

abstract：:FR134043, disodium(Z,1S,15S,8S,24S,27R,29S,34S,37R)-29-ben zyl-21-ethylidene-27-hydroxy-15-isobutyrylamino-34-isopropyl-31,37 -dimethyl-10,16,19,22,30,32,35,38-octaoxo-36-oxa-9,11,17,20,23,28, 31,33-octaazatetracyclo[16.13.6.1(24),(28).0(3),(8)]octatricont a-3,5,7-trien-5,6-diyl disulfate, is a water-soluble inhibitor...

journal_title：European journal of pharmacology

authors： Shinguh Y,Yamazaki A,Inamura N,Fujie K,Okamoto M,Nakahara K,Notsu Y,Okuhara M,Ono T

更新日期：1998-03-26 00:00:00

abstract：:Apoptosis has received widespread attention for its essential roles in biology, medicine and cancer. We previously found that normal, human papillomavirus (HPV) 16-immortalized and their transformed endocervical cells were increasingly resistant to apoptosis induced by a cancer therapeutic drug. Here, analogously, ano...

journal_title：European journal of pharmacology

authors： Mo B,Pater A

更新日期：2003-04-25 00:00:00

abstract：:All-night spectral analysis of the sleep EEG was used to study the effect and after-effect of a single bedtime dose of flunitrazepam (2 mg), flurazepam (30 mg) or triazolam (0.5 mg) in healthy young males. In the night of drug treatment all 3 hypnotics reduced the EEG slow waves and enhanced the activity in the freque...

journal_title：European journal of pharmacology

authors： Borbély AA,Mattmann P,Loepfe M,Fellmann I,Gerne M,Strauch I,Lehmann D

更新日期：1983-04-22 00:00:00

abstract：:The effect of NZ-107 (4-bromo-5-(3-ethoxy-4-methoxybenzylamino)-3(2H)-pyridazinone) on late-phase airway responses and airway hyperreactivity was investigated in the guinea pig. Challenge with inhaled ovalbumin in conscious guinea pigs actively sensitized with inhaled ovalbumin caused triphasic bronchial obstruction, ...

journal_title：European journal of pharmacology

authors： Iwama T,Shikada K,Yamamoto A,Sakashita M,Hibi M,Tanaka S

更新日期：1991-07-09 00:00:00

abstract：:The effects of GABA on depolarization-induced (26 mM K+) release of radiolabeled dopamine (DA) and acetylcholine (ACh) from slices of rat caudate nucleus were examined with a superfusion method. GABA, in concentrations of 10(-5)--10(-3) M, dose-dependently enhanced the release of DA, either accumulated by high-affinit...

journal_title：European journal of pharmacology

authors： Stoof JC,Den Breejen EJ,Mulder AH

更新日期：1979-07-15 00:00:00

abstract：:Antinociceptive effects of various neuroleptics in animal acute pain-models have been described, mediated trough different pathways including the opioid system. In this study, we assessed the antinociceptive effects of the atypical neuroleptic drug amisulpride, which acts as a selective blocker of dopamine D2 and D3 r...

journal_title：European journal of pharmacology

authors： Weizman T,Pick CG,Backer MM,Rigai T,Bloch M,Schreiber S

更新日期：2003-10-08 00:00:00

abstract：:The effects of cannabinoid drugs on cAMP production were examined in mammalian brain. The cannabinoid receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrrolo[1,2,3,-d,e-1,4-benzoxazin-6-yl]-(1-naphthalenyl) methanone (WIN55,212-2) decreased forskolin-induced cAMP accumulation in a concentration...

journal_title：European journal of pharmacology

authors： Mato S,Pazos A,Valdizán EM

更新日期：2002-05-17 00:00:00

abstract：:A few decades ago, cardiac muscle was discovered to possess signalling pathways that, when activated, protect the myocardium against the damage induced by ischaemia-reperfusion. The ability of cardiac muscle to protect itself against injury has been termed 'cardioprotection'. Many compounds and procedures can trigger ...

journal_title：European journal of pharmacology

authors： Jovanović A

更新日期：2018-08-15 00:00:00

abstract：:The effects of procaine, mepivacaine and phenylbutazone on pain perception in the equine were studied using two behavioral assays of nociception; the thermal evoked hoof withdrawal reflex and skin twitch reflex. Pain perception threshold was measured as the latency from onset of thermal stimuli to reflex withdrawal of...

journal_title：European journal of pharmacology

authors： Kamerling SG,Dequick DJ,Weckman TJ,Sprinkle FP,Tobin T

更新日期：1984-12-15 00:00:00

abstract：:The cardiovascular protecting effect of the grape fruit trans-resveratrol has been explained among other factors, through augmentation of nitric oxide (NO) production in cardiovascular tissues. Another effect of low resveratrol concentration is the inhibition of single-vesicle quantal release of catecholamine from bov...

journal_title：European journal of pharmacology

authors： Padín JF,de Diego AM,Fernández-Morales JC,Merino C,Maroto M,Calvo-Gallardo E,Arranz JA,Yáñez M,García AG

更新日期：2012-06-15 00:00:00

abstract：:High stereoselectivity was observed for the enantiomers of trihexyphenidyl and trihexyphenidyl methiodide at muscarinic M1-receptors in field-stimulated rabbit vas deferens and at M2 alpha- and M2 beta-receptors in guinea-pig atrium and ileum, respectively. Considerably higher affinities (up to 1700-fold) were found f...

journal_title：European journal of pharmacology

authors： Lambrecht G,Feifel R,Moser U,Aasen AJ,Waelbroeck M,Christophe J,Mutschler E

更新日期：1988-10-11 00:00:00

abstract：:We investigated intracellular Ca2+ regulation in pancreatic acinar cells from rats with diabetes induced by a single injection of streptozotocin (80 mg/kg). Experiments were performed 2 days and 7 days after the injection of streptozotocin. The density of muscarinic receptors, measured by [3H]N-methyl scopolamine bind...

journal_title：European journal of pharmacology

authors： Komabayashi T,Sawada H,Izawa T,Kogo H

更新日期：1996-03-18 00:00:00

abstract：:Effects of the alpha2-adrenoceptor antagonist yohimbine on the antinociception produced by a low dose of naloxone were examined in a rat model of carrageenan-induced inflammation. In rats receiving saline prior to naloxone injection, the low dose of naloxone (5 microg/kg, i.p.) significantly prolonged paw withdrawal l...

journal_title：European journal of pharmacology

authors： Tsuruoka M,Hiruma Y,Matsutani K,Matsui Y

更新日期：1998-05-08 00:00:00

abstract：:Local infusions of PYY (3-100 pmol.min-1) caused a slowly developing vasoconstriction of a long duration in the cat submandibular salivary gland. The vasoconstrictor action of PYY was also present after alpha-adrenoceptor blockade and in sympathectomized animals. Local APP infusions caused only weak vasoconstriction. ...

journal_title：European journal of pharmacology

authors： Lundberg JM,Tatemoto K

更新日期：1982-09-10 00:00:00

abstract：:Coagulopathy is the major cause of organ injury as well as a strong predictor of mortality in septic patients. Systemic inflammatory response and redox imbalance are regarded as the major causes of sepsis-induced coagulopathy. There is growing evidence that a vasodilator hydralazine has beneficial effects on heart fai...

journal_title：European journal of pharmacology

authors： Huang HC,Hsiao TS,Liao MH,Tsao CM,Shih CC,Wu CC

更新日期：2020-09-05 00:00:00

abstract：:Apoptosis or programmed cell death has been suggested as an important mode of neurodegeneration in Alzheimer's disease pathogenesis. The present study explored the neuroprotective effect of 2-ethoxy-4,5-diphenyl-1,3-oxazine-6-one (EDPOO) against H(2)O(2)-induced cell death in rat pheochromocytoma (PC12) cells. We foun...

journal_title：European journal of pharmacology

authors： Ansari N,Khodagholi F,Amini M

更新日期：2011-05-11 00:00:00

abstract：:Several lines of evidence suggest that acetylcholinesterase inhibitors (AChE) have their cognitive enhancing effects by stimulating cholinergic receptors within the medial septum. However, intraseptal administration of cholinergic enhancing drugs produce mixed results that appear to depend on both the integrity of the...

journal_title：European journal of pharmacology

authors： Roland JJ,Levinson M,Vetreno RP,Savage LM

更新日期：2010-03-10 00:00:00

abstract：:Accumulating evidence has suggested that Glypican-5 (GPC5) is a tumor suppressor gene in many types of cancers. However, whether GPC5 is involved in glioma remains unknown. This study was designed to explore the expression, biological function and regulatory mechanism of GPC5 in glioma. Our results demonstrated that G...

journal_title：European journal of pharmacology

authors： Hong X,Zhang Z,Pan L,Ma W,Zhai X,Gu C,Zhang Y,Bi X,Huang W,Pei H,Liu Z

更新日期：2019-07-05 00:00:00

abstract：:The effects of lorcainide and its metabolite norlorcainide on the maximal rate of depolarization (Vmax) were compared at different rates of stimulation and at various membrane potentials in ventricular muscle preparations of guinea-pig heart. A standard microelectrode technique was used. The results show that lorcaini...

journal_title：European journal of pharmacology

authors： Carmeliet E

更新日期：1987-01-06 00:00:00

abstract：:The effects of MP 518, an acylated 2-chlorobenzylidene hydrazidone derivative with antihypertensive properties were investigated on the Ca current, ICa, recorded under whole-cell patch-clamp in single frog ventricular cells. MP 518 (1-100 microM) had no effect on ICa under control conditions. However, at 10 microM it ...

journal_title：European journal of pharmacology

authors： Scamps F,Tran G,Rinjard P,Binet P,Miocque M,Vassort G

更新日期：1993-01-15 00:00:00

abstract：:Piperine, a main component of Piper longum Linn. and Piper nigrum Linn., is a plant alkaloid with a long history of medical use. Piperine exhibits anti-inflammatory activity; however, the underlying mechanism remains unknown. We examined the effects of piperine on lipopolysaccharide (LPS)-induced inflammatory response...

journal_title：European journal of pharmacology

authors： Bae GS,Kim MS,Jung WS,Seo SW,Yun SW,Kim SG,Park RK,Kim EC,Song HJ,Park SJ

更新日期：2010-09-10 00:00:00

abstract：:In the present study, we tested whether the decreased release of calcitonin gene-related peptide (CGRP) observed in nitroglycerin tolerance is associated with the decrease in aldehyde dehydrogenase (ALDH-2) activity. We further investigated the possible involvement of reactive oxygen species in the decrease in ALDH-2 ...

journal_title：European journal of pharmacology

authors： Chen YR,Nie SD,Shan W,Jiang DJ,Shi RZ,Zhou Z,Guo R,Zhang Z,Li YJ

更新日期：2007-09-24 00:00:00