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Effects of yohimbine on naloxone-induced antinociception in a rat model of inflammatory hyperalgesia.

Abstract：

:Effects of the alpha2-adrenoceptor antagonist yohimbine on the antinociception produced by a low dose of naloxone were examined in a rat model of carrageenan-induced inflammation. In rats receiving saline prior to naloxone injection, the low dose of naloxone (5 microg/kg, i.p.) significantly prolonged paw withdrawal latency in response to noxious thermal stimuli for both the inflamed and the non-inflamed paws 4 h after carrageenan injection (6.0 mg in 0.15 ml saline). In rats receiving yohimbine, the low dose of naloxone failed to produce prolongation of paw withdrawal latencies 4 h after carrageenan, whereas naloxone produced antinociception 7 days after carrageenan. The results suggest that noradrenergic mechanisms are involved in naloxone-induced antinociception only in the early phase of carrageenan-induced inflammation.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Tsuruoka M,Hiruma Y,Matsutani K,Matsui Y

doi

10.1016/s0014-2999(98)00151-4

subject

Has Abstract

pub_date

1998-05-08 00:00:00

pages

161-5

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(98)00151-4

journal_volume

348

pub_type

杂志文章

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