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Effect of staurosporine, a protein kinase C inhibitor, on impairment of working memory in rats exposed to cerebral ischemia.

Abstract：

:A 5-min period of cerebral ischemia induced in rats by the four-vessel occlusion method increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) assessed by a working memory procedure applied in a three-panel runway task. The protein kinase C (PKC) inhibitor, staurosporine 0.03 and 0.1 mg/kg, administered immediately after blood flow reperfusion, significantly reduced the increase in errors expected to occur 24 h after 5 min of ischemia. However, administration of staurosporine 0.1 mg/kg 6 h after ischemia had no effect on the increase in errors. The protective effect of staurosporine suggests that the enhanced PKC activity during the early reperfusion phase plays a crucial role in the post-ischemic impairment of working memory.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Ohno M,Yamamoto T,Watanabe S

doi

10.1016/0014-2999(91)90844-g

subject

Has Abstract

pub_date

1991-10-29 00:00:00

pages

113-6

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(91)90844-G

journal_volume

204

pub_type

杂志文章

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