Abstract:
:Intravenous administration of 0.3 mg/kg of quinpirole to conscious rabbits that had been pretreated with domperidone caused a marked increase in blood pressure and renal sympathetic nerve activity with a peak at 5-10 min after injection (25% and 3-fold increase, respectively). Spectral analysis of the blood pressure-renal sympathetic nerve activity relationship in the 0.2-0.4 Hz domain showed that baroreflex gain was markedly increased at 5-10 min (4-fold) and at 20-25 min after injection (3.7-fold). These results show that administration of the dopamine D(2)/D(3) receptor agonist quinpirole causes profound and long-lasting changes in the central integration of the sympathetic baroreceptor-vasomotor reflex.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
van den Buuse M,Head GAdoi
10.1016/s0014-2999(99)00835-3keywords:
subject
Has Abstractpub_date
2000-01-24 00:00:00pages
85-8issue
1eissn
0014-2999issn
1879-0712pii
S0014-2999(99)00835-3journal_volume
388pub_type
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journal_title:European journal of pharmacology
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