Abstract:
:It had previously been shown that D-phenylalanine and hydrocinnamic acid, two in vitro inhibitors of carboxypeptidase A, possess an analgesic action when injected i.p. in mice. We have studied the in vivo effects of indole-3-acetic acid, another carboxypeptidase A inhibitor, and of the following analogs of D-phenylalanine substituted in position 4: D-tyrosine, p-fluoro-D-phenylalanine and trifluoroacetyl-p-fluoro-D-phenylalanine. Whereas indole-3-acetic acid caused a higher and shorter analgesia in comparison with D-phenylalanine, p-fluoro-D-phenylalanine and its N-trifluoroacetyl derivative yielded both a greater and a much longer lasting analgesic effect. Since the latter compound showed only slight inhibitory activity on carboxypeptidase A in vitro, we suggest that inhibition of this enzyme and analgesia might not be directly correlated.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Giusti P,Carrara M,Cima L,Borin Gdoi
10.1016/0014-2999(85)90164-5subject
Has Abstractpub_date
1985-10-22 00:00:00pages
287-92issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(85)90164-5journal_volume
116pub_type
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