Methylxanthine activation of noradrenergic unit activity and reversal by clonidine.

abstract：:Acanthopanax senticosides B is a monomer of Acanthopanax senticosus saponins. Previous reports showed that Acanthopanax senticosus saponins exhibit antioxidant action and cardiac protection. However, whether Acanthopanax senticosides B has cardiac protection remains unknown. In this study, we investigated the effect o...

journal_title：European journal of pharmacology

authors： Liang Q,Yu X,Qu S,Xu H,Sui D

更新日期：2010-02-10 00:00:00

abstract：:A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healthy volunteers. The equilibrium dissociation constant for binding by [3H]PK 1...

journal_title：European journal of pharmacology

authors： Gavish M,Weizman A,Karp L,Tyano S,Tanne Z

更新日期：1986-02-18 00:00:00

abstract：:Previous results indicated that the rabbit could represent a suitable model for investigations on the functional role of alpha 2-adrenoceptors in fat cells, but the characterization of these receptors was not resolved yet. In the present report, imidazoline compounds were used to attempt a better definition of rabbit ...

journal_title：European journal of pharmacology

authors： Langin D,Paris H,Dauzats M,Lafontan M

更新日期：1990-04-25 00:00:00

abstract：:To explore the possibility that raloxifene might influence an adipocyte differentiation and lipogenesis, we studied the effects of raloxifene on the expression of adiponectin and other peroxisome proliferator-activated receptor gamma targeting genes using the 3T3-L1 adipocytes. With standard adipogenic inducers, we ad...

journal_title：European journal of pharmacology

authors： Murase Y,Kobayashi J,Nohara A,Asano A,Yamaaki N,Suzuki K,Sato H,Mabuchi H

更新日期：2006-05-24 00:00:00

abstract：:Edaravone is a potent scavenger of hydroxyl radicals and attenuates oxidative damage-related neurodegenerative diseases. Previous studies suggest that oxidative stress plays a key role in the pathogenesis of diabetes. The present study examined the effect of edaravone on diabetes in multiple low-dose streptozotocin-tr...

journal_title：European journal of pharmacology

authors： Fukudome D,Matsuda M,Kawasaki T,Ago Y,Matsuda T

更新日期：2008-03-31 00:00:00

abstract：:The quaternary antagonist gallamine discriminates subpopulations of muscarinic receptors in the forebrain and brainstem of the rat and also modulates the binding of other muscarinic ligands via an allosteric mechanism in both brain regions. The calcium channel antagonist verapamil exhibits a similar allosteric effect ...

journal_title：European journal of pharmacology

authors： Ellis J,Seidenberg M

更新日期：1987-11-24 00:00:00

abstract：:Excess cytokine produced by inflammatory stimuli contributes to the progression of myocardial damage in myocarditis. Angiotensin-II has been shown to play a pivotal role in the pathophysiology of various organs, especially the cardiovascular system. Some angiotensin II type 1 receptor antagonists are reported to inhib...

journal_title：European journal of pharmacology

authors： Sukumaran V,Watanabe K,Veeraveedu PT,Ma M,Gurusamy N,Rajavel V,Suzuki K,Yamaguchi K,Kodama M,Aizawa Y

更新日期：2011-02-10 00:00:00

abstract：:The effects of N- and L-type voltage operated calcium channel (VOCC) antagonists were examined on the bronchoconstriction induced by vagal stimulation in artificially respired guinea-pigs. Vagal stimulation produced a reproducible and consistent bronchoconstrictor response which corresponded to an increase in pulmonar...

journal_title：European journal of pharmacology

authors： Boot JR,Bond A

更新日期：1992-08-14 00:00:00

abstract：:Two splice variants of the pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor (PACAP receptor and PACAP/HOP receptor isoform) were stably expressed in Chinese hamster ovary (CHO) cells that did not express constitutively receptors for this family of peptides. The PACAP/HOP receptor protein had ...

journal_title：European journal of pharmacology

authors： Ciccarelli E,Svoboda M,De Neef P,Di Paolo E,Bollen A,Dubeaux C,Vilardaga JP,Waelbroeck M,Robberecht P

更新日期：1995-02-15 00:00:00

abstract：:The distribution of P2-purinoceptors in pre-capillary resistance vessels was studied in vitro, using Krebs perfused rabbit ears and in vivo, in autoperfused hindquarters, intestinal and renal vasculatures of pentobarbitone anaesthetised cats. ATP (10(-10)-10(-6) mol i.a.) caused dose-dependent vasodilatation which, in...

journal_title：European journal of pharmacology

authors： Taylor EM,Parsons ME,Wright PW,Pipkin MA,Howson W

更新日期：1989-02-28 00:00:00

abstract：:Receptor for advanced glycation end-products (RAGE) is involved in the pathogenesis of diabetic nephropathy. FPS-ZM1, a selective RAGE inhibitor, in combination with valsartan were investigated for their protective potentials on the renal markers of tubular injury in streptozotocin-induced diabetic rats. Rats were ass...

journal_title：European journal of pharmacology

authors： Sanajou D,Ghorbani Haghjo A,Argani H,Roshangar L,Rashtchizadeh N,Ahmad SNS,Ashrafi-Jigheh Z,Bahrambeigi S,Asiaee F,Rashedi J,Aslani S

更新日期：2019-01-05 00:00:00

abstract：:In the search for a selective delta-opioid receptor agonist, (-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082) and the (+)-enantiomer were synthesized and tested. (-)-NIH 11082 displayed antinociceptive activity in the paraphenylquinone test (PPQ test) in male ICR...

journal_title：European journal of pharmacology

authors： Aceto MD,May EL,Harris LS,Bowman ER,Cook CD

更新日期：2007-07-02 00:00:00

abstract：:The convulsant, anticonvulsant and anaesthetic activities of a series of 6 barbiturates related to pentobarbitone have been qualitatively and quantitatively determined in mice. The presence or absence of convulsant activity was strongly dependent on molecular structure and there were marked variations in potency among...

journal_title：European journal of pharmacology

authors： Andrews PR,Jones GP,Poulton DB

更新日期：1982-04-08 00:00:00

abstract：:The excitatory mechanism of central sympathetic outflow induced by interleukin-1 beta was investigated in urethane-anesthetized rats. Intracerebroventricular administration of interleukin-1 beta induced a gradually developing elevation of plasma noradrenaline levels in a dose-dependent manner (50, 100 and 200 ng/anima...

journal_title：European journal of pharmacology

authors： Murakami Y,Yokotani K,Okuma Y,Osumi Y

更新日期：1996-12-12 00:00:00

abstract：:Carbachol produces both negative and positive inotropy in rat left atria. It is not clear whether these two effects are mediated by two separate cell surface muscarinic receptors or a single receptor interacting with two coupling proteins in the cell membrane. Pirenzepine, known to selectively block some biochemical m...

journal_title：European journal of pharmacology

authors： Boselli C,Kenakin TP

更新日期：1990-11-20 00:00:00

abstract：:(5R,6R)-6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[ 3.2.1]octane (PTAC) is a selective muscarinic receptor ligand. The compound exhibits high affinity for central muscarinic receptors with partial agonist mode of action at muscarinic M(2) and M(4) and antagonist mode of action at muscarinic M(1), M(3) and M(5...

journal_title：European journal of pharmacology

authors： Rasmussen T,Sauerberg P,Nielsen EB,Swedberg MD,Thomsen C,Sheardown MJ,Jeppesen L,Calligaro DO,DeLapp NW,Whitesitt C,Ward JS,Shannon HE,Bymaster FP,Fink-Jensen A

更新日期：2000-08-25 00:00:00

abstract：:High pressure liquid chromatography (HPLC) combined with radiochemical detection was used to show that [3H]noradrenaline (NA) and [14C]ATP were released concomitantly during field stimulation of the rat vas deferens. The release of radioactivity (3H and 14C) in response to three consecutive field stimulations was cons...

journal_title：European journal of pharmacology

authors： Vizi ES,Burnstock G

更新日期：1988-12-06 00:00:00

abstract：:The mechanisms underlying the contractile effects of neuropeptide Y (NPY) in relation to those of noradrenaline (NA) on small human blood vessels were studied in vitro. NPY caused contractions of mesenteric veins, renal and skeletal muscle arteries but not of mesenteric arteries. NPY was about 5- to 10-fold more poten...

journal_title：European journal of pharmacology

authors： Pernow J,Svenberg T,Lundberg JM

更新日期：1987-04-14 00:00:00

abstract：:We investigated the inhibitory effects of 1 mM of the inorganic cations, La3+, Cd2+, Mn2+, Ni2+ and Co2+ on contractions induced by K+ (100 mM) and 5-hydroxytryptamine (5-HT, 10(-5) M) in the isolated rat jugular vein and on contractions induced by K+ (100 mM), 5-HT (10(-5] and noradrenaline (NA, 10(-5) M) in the rat ...

journal_title：European journal of pharmacology

authors： Gouw MA,Wilffert B,Van Zwieten PA

更新日期：1990-08-28 00:00:00

abstract：:The effects of capsaicin pretreatment on withdrawal responses of guinea-pig isolated ileum to [Met5]enkephalin (ME) and morphine and on the locomotor withdrawal response of guinea-pigs following a single dose of morphine, were investigated. In vitro treatment of ileum with capsaicin, 1.5 mumol/l for 1 h, did not signi...

journal_title：European journal of pharmacology

authors： Chahl LA

更新日期：1988-12-06 00:00:00

abstract：:Extravasation elicited in rat skin by antidromic electrical stimulation of the saphenous nerve was dose dependently inhibited by the intravenous (i.v.) application of the mu-opioid receptor agonists, morphine and [D-Ala2,Me-Phe4,Gly-ol5]enkephalin (DAGO), and the kappa-opioid receptor agonists (-)-U 50488H, (-)-ICI 19...

journal_title：European journal of pharmacology

authors： Barber A

更新日期：1993-05-12 00:00:00

abstract：:The acute administration of MDMA has been shown to promote glycogenolysis and increase the extracellular concentration of glucose in the striatum. In the present study the role of serotonergic and/or noradrenergic mechanisms in the MDMA-induced increase in extracellular glucose and glycogenolysis was assessed. The rel...

journal_title：European journal of pharmacology

authors： Pachmerhiwala R,Bhide N,Straiko M,Gudelsky GA

更新日期：2010-10-10 00:00:00

abstract：:The effects of 26 anesthetic agents were studied on the rhythmical discharge activity of a single isolated neuron (crayfish stretch receptor). Many of these agents produced concentration-dependent biphasic responses (excitation and depression), and some also induced altered discharge patterns (burst activity). The dom...

journal_title：European journal of pharmacology

authors： MacIver MB,Roth SH

更新日期：1987-07-02 00:00:00

abstract：:YM992 ((S)-2-[[(7-fluoro-4-indanyl)oxy]methyl]morpholine monohydrochloride) is a novel compound that has selective serotonin (5-hydroxytryptamine, 5-HT) re-uptake inhibition and 5-HT2A receptor antagonistic activity in vivo. YM992, fluoxetine and citalopram showed 5-HT uptake inhibition activity in l-5-hydroxy-tryptop...

journal_title：European journal of pharmacology

authors： Takeuchi H,Yatsugi S,Hatanaka K,Nakato K,Hattori H,Sonoda R,Koshiya K,Fujii M,Yamaguchi T

更新日期：1997-06-18 00:00:00

abstract：:Hyperphosphatemia is associated with severe decline of renal function in chronic kidney disease and elevates cardiovascular mortality. Type II sodium dependent phosphate transporter 2A (Npt2A) plays a major role in renal phosphate reabsorption and could be explored as a target for anti-hyperphosphatemia therapy. Human...

journal_title：European journal of pharmacology

authors： Wu H,Mao C,Duenstl G,Su W,Qian S

更新日期：2013-12-05 00:00:00

abstract：:Arvanil is a metabolically stable hybrid between anandamide and capsaicin. The present study was designed to test the role of the vagal pathway in post-arvanil respiratory and blood pressure responses. Respiratory and pressure changes evoked by an intravenous injection of arvanil were investigated in 21 urethane-chlor...

journal_title：European journal of pharmacology

authors： Kopczyńska B

更新日期：2010-09-15 00:00:00

abstract：:A possible cross-competition between vasoactive intestinal peptide (VIP) and somatostatin (somatotropin release inhibiting factor; SRIF) and their respective receptors, was investigated at native or recombinant SRIF and VIP/pituitary adenylate cyclase-activating polypeptide (PACAP) receptors. The activity of VIP was e...

journal_title：European journal of pharmacology

authors： Hannon JP,Langenegger D,Waser B,Hoyer D,Reubi JC

更新日期：2001-08-31 00:00:00

abstract：:Injection into the superior colliculus of anaesthetised rats of the nitric oxide (NO) synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 1 micromol), but not its inactive enantiomer N(omega)-nitro-D-arginine methyl ester (D-NAME; 1 micromol), significantly (P < 0.01) increased the mean arterial blood p...

journal_title：European journal of pharmacology

authors： D'Amico M,Rossi F,Warner TD

更新日期：1997-06-05 00:00:00

abstract：:Cell-cell interaction through binding of intercellular adhesion molecule (ICAM), B7.1, B7.2 and CD40 on monocytes to their ligands on T-cells plays a number of roles in cytokine . High mobility group box 1 (HMGB1), an abundant and conserved nuclproduction and lymphocyte proliferationear protein, acts in the extracellu...

journal_title：European journal of pharmacology

authors： Kohka Takahashi H,Sadamori H,Liu K,Wake H,Mori S,Yoshino T,Yamamoto Y,Yamamoto H,Nishibori M

更新日期：2013-02-15 00:00:00

abstract：:In the present study, we tested whether the decreased release of calcitonin gene-related peptide (CGRP) observed in nitroglycerin tolerance is associated with the decrease in aldehyde dehydrogenase (ALDH-2) activity. We further investigated the possible involvement of reactive oxygen species in the decrease in ALDH-2 ...

journal_title：European journal of pharmacology

authors： Chen YR,Nie SD,Shan W,Jiang DJ,Shi RZ,Zhou Z,Guo R,Zhang Z,Li YJ

更新日期：2007-09-24 00:00:00