Abstract:
:Heme oxygenase is the rate-limiting enzyme in the catabolism of heme to carbon monoxide, bilirubin and free iron. Many cell types express heme oxygenase-2 constitutively while heme oxygenase-1 is induced at sites of inflammation and oxidative stress. In systemic blood vessels, carbon monoxide may have an important homeostatic role where, like its better-studied counterpart nitric oxide, it is emerging as a vasodilator and an inhibitor of proliferation. However, much less is known regarding the role of heme oxygenase and carbon monoxide in the pulmonary circulation where vascular responses are very different. Here, using primary cultures of human pulmonary artery smooth muscle cells, we present novel data showing that this cell type expresses heme oxygenase-2 constitutively and, in the presence of oxidants, can induce heme oxygenase-1. We also show that the carbon monoxide-releasing molecule, tricarbonyldichlororuthenium (II) dimer, potently and profoundly inhibits proliferation of human pulmonary artery smooth muscle cells. Pulmonary hypertension is a disease characterised by abnormal vascular smooth muscle cell growth and remodelling of the pulmonary vasculature. Our observations support the growing evidence that the heme oxygenase/carbon monoxide system may play a role in the pathology of pulmonary hypertension.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Stanford SJ,Walters MJ,Hislop AA,Haworth SG,Evans TW,Mann BE,Motterlini R,Mitchell JAdoi
10.1016/s0014-2999(03)02001-6keywords:
subject
Has Abstractpub_date
2003-07-25 00:00:00pages
135-41issue
2-3eissn
0014-2999issn
1879-0712pii
S0014299903020016journal_volume
473pub_type
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