当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells.

Cloricromene synergizes with antiplatelet drugs and nitric oxide-like factor derived from rat peritoneal polymorphonuclear cells.

Abstract：

:We report that cloricromene (5-30 microM) inhibited thrombin-induced platelet aggregation and synergized with other antiplatelet compounds. The antiaggregatory effect of subthreshold concentrations of the prostaglandin (PG)I2 analogue, iloprost (0.2 nM), or of sodium nitroprusside (1 micron), acting through a nitric oxide (NO)-like mechanism, was significantly potentiated by co-incubation with cloricromene (5 microM). In addition, cloricromene enhanced the antiplatelet activity of the NO-like factor released by peritoneal rat polymorphonuclear cells. Thus, the present results show that cloricromene possesses direct antiplatelet properties and synergizes with other endogenous as well as exogenous antiplatelet compounds.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Mollace V,Prosdocimi M,Nisticó G

doi

10.1016/0014-2999(92)90853-v

keywords:

subject

Has Abstract

pub_date

1992-11-10 00:00:00

pages

181-4

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(92)90853-V

journal_volume

222

pub_type

杂志文章

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