Abstract:
:Sigma 1 receptor (σ₁ receptor) is a unique ligand-regulated molecular chaperone located mainly in the endoplasmic reticulum and the plasma membrane. σ₁ receptor is activated under stress or pathological conditions and interacts with several neurotransmitter receptors and ion channels to modulate their function. The effects reported preclinically with σ₁ receptor ligands are consistent with a role for σ₁ receptor in central sensitization and pain hypersensitivity and suggest a potential therapeutic use of σ₁ receptor antagonists for the management of neuropathic pain as monotherapy. Moreover, data support their use in opioid adjuvant therapy: combination of σ₁ receptor antagonists and opioids results in potentiation of opioid analgesia, without significant increases in opioid-related unwanted effects. Results from clinical trials using selective σ₁ receptor antagonists in several pain conditions are eagerly awaited to ascertain the potential of σ₁ receptor modulation in pain therapy.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Zamanillo D,Romero L,Merlos M,Vela JMdoi
10.1016/j.ejphar.2013.01.068subject
Has Abstractpub_date
2013-09-15 00:00:00pages
78-93issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(13)00167-2journal_volume
716pub_type
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